Published in Toxicol Rep on July 30, 2014
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet (1993) 6.53
Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet (2004) 4.11
Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr (2005) 4.01
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol (2005) 2.91
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol (2007) 2.21
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med (2004) 2.07
Defects in mitochondrial DNA replication and human disease. Crit Rev Biochem Mol Biol (2011) 1.86
Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number. Biochim Biophys Acta (2012) 1.59
Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol (2001) 1.57
Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr (2008) 1.47
Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci U S A (2010) 1.38
The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res (2002) 1.35
The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets (2010) 1.30
Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat Res (2005) 1.28
Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J Biomed Sci (2002) 1.18
Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis? Cell Growth Differ (1997) 1.17
Mitochondrial reactive oxygen species production and elimination. J Mol Cell Cardiol (2014) 1.15
High mitochondrial DNA copy number has detrimental effects in mice. Hum Mol Genet (2010) 1.15
The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA. J Biochem (2006) 1.11
Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother Res (2012) 1.10
Structure-antioxidant activity relationships of flavonoids: a re-examination. Free Radic Res (2002) 1.09
Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro (2009) 1.06
Dietary flavonol intake may lower stroke risk in men and women. J Nutr (2010) 1.05
Safety of quercetin for clinical application (Review). Int J Mol Med (2005) 1.05
Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol Int (2007) 1.03
Potential health impacts of excessive flavonoid intake. Free Radic Biol Med (2000) 1.03
Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur J Nutr (2005) 0.98
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid. J Nutr Biochem (2009) 0.96
Site-specific anticancer effects of dietary flavonoid quercetin. Nutr Cancer (2013) 0.95
Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis. Free Radic Biol Med (2013) 0.94
Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochem Biophys Res Commun (2003) 0.92
The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp Cell Res (2003) 0.90
Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem (2005) 0.90
Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α. Cell Death Dis (2013) 0.89
The increase in mitochondrial DNA copy number in the tissues of gamma-irradiated mice. Cell Mol Biol Lett (2005) 0.88
Effects of X-irradiation on mitochondrial DNA damage and its supercoiling formation change. Mitochondrion (2011) 0.88
POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts. Biochim Biophys Acta (2010) 0.87
Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy. Clin Nutr (2012) 0.86
Plant polyphenols: are they the new magic bullet? Proc Nutr Soc (2003) 0.86
Replication of murine mitochondrial DNA following irradiation. Adv Exp Med Biol (2009) 0.86
Formation and repair of oxidative damage in the mitochondrial DNA. Mitochondrion (2014) 0.84
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PLoS One (2012) 0.83
Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity. Life Sci (2010) 0.80
Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice. AIDS Res Treat (2012) 0.80
Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy. Radiat Oncol (2011) 0.79
Elevated mitochondrial DNA copy number and POL-γ expression but decreased expression of TFAM in murine intestine following therapeutic dose irradiation. Adv Exp Med Biol (2011) 0.79
Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. Cancer Lett (1991) 0.79
Curcumin protects the seminal vesicles from metronidazole-induced reduction of secretion in mice. Acta Medica (Hradec Kralove) (2012) 0.78
Potential of phenolic antioxidants. Acta Chim Slov (2010) 0.77