Published in Oncotarget on June 27, 2017
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Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Mutational landscape and significance across 12 major cancer types. Nature (2013) 14.91
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer (2007) 8.17
Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res (2005) 3.63
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep (2002) 3.53
Notch signaling in leukemia. Annu Rev Pathol (2008) 3.21
Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res (2004) 2.90
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature (2009) 2.87
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol (2003) 2.66
The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation. Nucleic Acids Res (2002) 2.43
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A (2007) 2.13
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell (2014) 1.98
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat Struct Mol Biol (2009) 1.98
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A (2004) 1.85
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer Cell (2015) 1.56
The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol (2012) 1.53
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci U S A (2008) 1.50
Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal (2014) 1.37
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol (2010) 1.32
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer (2015) 1.12
Mixed lineage leukemia: roles in human malignancies and potential therapy. FEBS J (2010) 1.12
Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. Mod Pathol (2006) 1.09
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem Cells (2014) 1.07
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ (2011) 1.07
A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res (2012) 0.96
The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol (2013) 0.96
Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med (2013) 0.95
Notching on Cancer's Door: Notch Signaling in Brain Tumors. Front Oncol (2015) 0.95
NOTCH3 is a prognostic factor that promotes glioma cell proliferation, migration and invasion via activation of CCND1 and EGFR. PLoS One (2013) 0.92
cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE). J Biol Chem (2012) 0.91
Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. PLoS One (2013) 0.89
The different role of Notch1 and Notch2 in astrocytic gliomas. PLoS One (2013) 0.89
Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing. Dev Biol (2009) 0.81
Zebrafish mll gene is essential for hematopoiesis. J Biol Chem (2011) 0.80
The complex role of NOTCH receptors and their ligands in the development of hepatoblastoma, cholangiocarcinoma and hepatocellular carcinoma. Biol Cell (2015) 0.78
Allograft Cancer Cell Transplantation in Zebrafish. Adv Exp Med Biol (2016) 0.78
Downregulation of Notch1 induces apoptosis and inhibits cell proliferation and metastasis in laryngeal squamous cell carcinoma. Oncol Rep (2015) 0.77
The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Dev Neurobiol (2014) 0.76
Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines. Int J Med Sci (2015) 0.75
Development of hair cells in inner ear is associated with expression and promoter methylation of Notch-1 in postnatal mice. Int J Clin Exp Med (2015) 0.75