The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 2863695)

Published in Mol Cell Biol on March 08, 2010

Authors

Hans-Martin Herz1, Laurence D Madden, Zhihong Chen, Clare Bolduc, Eugene Buff, Ravi Gupta, Ramana Davuluri, Ali Shilatifard, Iswar K Hariharan, Andreas Bergmann

Author Affiliations

1: M. D. Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA.

Articles citing this

The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61

Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31

Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome. Am J Hum Genet (2011) 2.14

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04

Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol (2011) 1.81

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest (2011) 1.66

The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54

acal is a long non-coding RNA in JNK signaling in epithelial shape changes during drosophila dorsal closure. PLoS Genet (2015) 1.46

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev (2011) 1.40

A complex Polycomb issue: the two faces of EZH2 in cancer. Genes Dev (2012) 1.32

SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22

Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol (2012) 1.20

Enhancer malfunction in cancer. Mol Cell (2014) 1.19

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proc Natl Acad Sci U S A (2014) 1.00

Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98

The H3K27me3 demethylase UTX in normal development and disease. Epigenetics (2014) 0.97

The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO J (2013) 0.97

Expression and significance of histone H3K27 demethylases in renal cell carcinoma. BMC Cancer (2012) 0.97

The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol (2013) 0.96

Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate. Hum Genet (2013) 0.94

CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci (2012) 0.87

UTX coordinates steroid hormone-mediated autophagy and cell death. Nat Commun (2013) 0.87

Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease. Mol Cell Biol (2013) 0.87

Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. Development (2013) 0.86

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner. Development (2013) 0.86

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1. EMBO Rep (2015) 0.85

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination. Clin Cancer Res (2014) 0.84

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res (2016) 0.84

Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX. Curr Opin Genet Dev (2016) 0.81

Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila. J Genet Genomics (2011) 0.81

Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis. PLoS Biol (2013) 0.78

Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases. BMC Res Notes (2012) 0.78

Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS One (2013) 0.76

Enhancer deregulation in cancer and other diseases. Bioessays (2016) 0.76

Histone lysine demethylases in Drosophila melanogaster. Fly (Austin) (2015) 0.75

Heterochromatin Reduction Correlates with the Increase of the KDM4B and KDM6A Demethylases and the Expression of Pericentromeric DNA during the Acquisition of a Transformed Phenotype. J Cancer (2017) 0.75

Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila. Sci Rep (2017) 0.75

Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation. Oncotarget (2017) 0.75

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04

Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21

Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90

Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31

The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68

Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43

Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28

Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21

Role of histone H3 lysine 27 methylation in X inactivation. Science (2003) 9.85

The E2F transcription factor is a cellular target for the RB protein. Cell (1991) 9.62

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91

The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays (1999) 7.89

Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet (2007) 7.61

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci (2001) 6.99

Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75

JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65

A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57

Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development (2000) 6.40

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14

Modulating Hox gene functions during animal body patterning. Nat Rev Genet (2005) 5.10

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet (2008) 5.08

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem (2007) 4.79

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 4.69

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Cell (1991) 4.42

Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell (1991) 4.37

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A (2007) 4.20

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet (2006) 3.83

Filling out the Hippo pathway. Nat Rev Mol Cell Biol (2007) 3.46

Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol (2006) 3.41

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev (1996) 2.92

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J (1991) 2.84

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol (1992) 2.78

Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron (1996) 2.44

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development (1998) 2.43

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A (1996) 2.35

Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev (1995) 2.33

Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev (1989) 2.32

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell (2007) 2.20

The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related. Genetics (1989) 2.06

Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster. Nat Genet (2003) 2.04

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development (1996) 2.03

Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci Signal (2009) 1.91

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol (2006) 1.85

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature (2006) 1.85

Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell (2005) 1.79

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol (2005) 1.78

A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature (1998) 1.74

Connections between epigenetic gene silencing and human disease. Mutat Res (2007) 1.72

The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev (2010) 1.62

The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Cell Death Differ (2009) 1.62

Roles of the Notch gene in Drosophila wing morphogenesis. Mech Dev (1994) 1.53

Shaping segments: Hox gene function in the genomic age. Bioessays (2008) 1.49

Dorsal-ventral signaling in the Drosophila eye. Science (1998) 1.40

Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development (2004) 1.40

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development (1997) 1.37

The Notch pathway in cancer: differentiation gone awry. Eur J Cancer (2005) 1.33

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development (1991) 1.26

A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development (1998) 1.22

Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Dev Biol (2005) 1.13

Notch and T cell malignancy. Semin Cancer Biol (2004) 1.02

Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg. Development (2001) 0.91

Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor. Development (2008) 0.82

Articles by these authors

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47

A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48

Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA (2009) 5.52

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49

Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49

An operational definition of epigenetics. Genes Dev (2009) 4.26

Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17

COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66

Carbon-based electronics. Nat Nanotechnol (2007) 3.60

Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem (2005) 3.55

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26

The language of histone crosstalk. Cell (2010) 3.18

Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91

Transparent, conductive carbon nanotube films. Science (2004) 2.89

Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89

Histone modification: cause or cog? Trends Genet (2011) 2.85

Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76

The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell (2005) 2.57

Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity (2006) 2.56

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53

Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53

Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol (2002) 2.42

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29

Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol (2010) 2.25

Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24

Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22

Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev Cell (2008) 2.21

The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development (2005) 2.19

Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell! Trends Cell Biol (2008) 2.12

Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem (2005) 2.10

The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04

Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell (2009) 2.03

Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00

The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell (2005) 1.99

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89

A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin. J Cell Biochem (2005) 1.88

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol (2006) 1.85

NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol (2007) 1.84

Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma. Clin Chem (2004) 1.80

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol (2004) 1.80

vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development (2006) 1.79

The predictive value of stable precursor fragments of vasoactive peptides in patients with chronic heart failure: data from the GISSI-heart failure (GISSI-HF) trial. Eur J Heart Fail (2010) 1.78

The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78

A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res (2007) 1.77

Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation. J Am Coll Cardiol (2010) 1.77

Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77

Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol (2010) 1.75

Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol (2009) 1.71

Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]. Crit Care (2006) 1.70

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69

Length scaling of carbon nanotube transistors. Nat Nanotechnol (2010) 1.64

High-sensitivity chemiluminescence immunoassays for detection of growth hormone doping in sports. Clin Chem (2009) 1.60

C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation (2007) 1.59

Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients. Peptides (2005) 1.57

Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock (2007) 1.57

ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell (2013) 1.57

Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila. Curr Biol (2010) 1.55

The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54

Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54

Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and Copeptin to predict 1-year mortality in patients with acute destabilized heart failure. J Card Fail (2007) 1.53

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52

Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome Res (2011) 1.52

Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. Cancer Res (2004) 1.52

Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. Circ J (2011) 1.52

WDR5, a complexed protein. Nat Struct Mol Biol (2009) 1.51

Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell (2008) 1.51

Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51

Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50

Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care (2005) 1.49

The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49

C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. Eur Heart J (2009) 1.48

Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev (2006) 1.46