Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28981112)

Published in Cell Death Dis on October 05, 2017

Authors

Dong Hou1, Guangwei Xu1, Caibo Zhang1, Boxuan Li1, Junchao Qin1, Xiaohe Hao1, Qiao Liu1, Xiyu Zhang1, Jinsong Liu2, Jianjun Wei3, Yaoqin Gong1, Zhaojian Liu4, Changshun Shao5

Author Affiliations

1: Department of Molecular Medicine and Genetics, Ministry of Education Key Laboratory of Experimental Teratology, Shandong University School of Medicine, Jinan, China.
2: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
3: Department of Pathology, Northwestern University School of Medicine, Chicago, IL, USA.
4: Department of Cell Biology, Shandong University School of Medicine, Jinan, China.
5: Department of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan 250012, China.

Articles cited by this

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res (2006) 6.28

Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer (2011) 5.28

Ovarian cancer. Annu Rev Pathol (2009) 4.92

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med (2004) 3.92

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res (2003) 3.85

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev (2012) 2.82

DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer (2012) 2.70

Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol (2009) 1.86

TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A (2007) 1.67

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res (2010) 1.64

Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol (2008) 1.36

Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation. Mol Cancer Ther (2007) 1.36

p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog (2009) 1.21

Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Arch Toxicol (2007) 1.16

Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. Cell Cycle (2012) 1.16

Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res (2008) 1.04

Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutat Res (2012) 1.00

Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. PLoS One (2011) 0.97

Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol Carcinog (2011) 0.94

Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One (2013) 0.93

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomedicine (2009) 0.92

Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway. Cancer Sci (2012) 0.92

Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway. Mol Cancer Ther (2014) 0.89

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis (2013) 0.87

Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity. J Ovarian Res (2014) 0.84

Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther (2015) 0.77