Published in Isr J Chem on January 19, 2017
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science (1997) 28.30
A specific amyloid-beta protein assembly in the brain impairs memory. Nature (2006) 16.19
Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56
Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature (2007) 10.02
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54
Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (2002) 5.58
Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science (2008) 5.55
Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol (2011) 4.98
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84
Curli biogenesis and function. Annu Rev Microbiol (2006) 4.77
Electron microscopic observations on a fibrous component in amyloid of diverse origins. Nature (1959) 4.43
Structural classification of toxic amyloid oligomers. J Biol Chem (2008) 4.16
Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue. Cell (2013) 4.02
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78
Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A (1998) 3.74
Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells. J Cell Biol (2001) 3.44
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Mol Biol Cell (2001) 2.48
Solid-state NMR studies of amyloid fibril structure. Annu Rev Phys Chem (2011) 2.38
Amyloid aggregates of the HET-s prion protein are infectious. Proc Natl Acad Sci U S A (2002) 2.37
A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell (2006) 2.29
Biology of amyloid: structure, function, and regulation. Structure (2010) 2.24
Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A (2009) 2.15
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol (2003) 2.12
A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12. Proc Natl Acad Sci U S A (1991) 1.97
Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol (2009) 1.94
The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. EMBO J (1999) 1.75
Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy. Q Rev Biophys (2008) 1.67
Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60
Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory. Cell (2012) 1.57
The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy. J Protein Chem (1996) 1.56
The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers. J Biol Chem (2006) 1.46
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils. Biochemistry (2009) 1.45
Inactivation of prions by acidic sodium dodecyl sulfate. J Virol (2006) 1.43
Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets. Proc Natl Acad Sci U S A (2008) 1.40
Structural insights into functional and pathological amyloid. J Biol Chem (2011) 1.39
Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity. J Mol Biol (2012) 1.38
Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis (2010) 1.33
The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem (2009) 1.30
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. J Biol Chem (2009) 1.28
Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A (2009) 1.28
The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis. Proc Natl Acad Sci U S A (2009) 1.25
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. Nat Struct Mol Biol (2016) 1.22
pH of melanosomes of B 16 murine melanoma is acidic: its physiological importance in the regulation of melanin biosynthesis. Arch Biochem Biophys (1993) 1.20
A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats. J Invest Dermatol (2003) 1.06
Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17. Proc Natl Acad Sci U S A (2010) 1.03
Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem (2007) 1.03
Segmental polymorphism in a functional amyloid. Biophys J (2011) 1.01
Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. J Biol Chem (2010) 0.97
Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet (2011) 0.97
Amyloid polymorphism: structural basis and neurobiological relevance. Neuron (2015) 0.95
Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH. J Biol Chem (2010) 0.95
Proprotein convertases process Pmel17 during secretion. J Biol Chem (2011) 0.94
Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils. Mol Biol Cell (2013) 0.91
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17. Phys Chem Chem Phys (2011) 0.90
Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue level. Biochemistry (2011) 0.86
The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB. Pigment Cell Melanoma Res (2013) 0.81
Lysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17. J Mol Biol (2014) 0.79
Molecular origin of pH-dependent fibril formation of a functional amyloid. Chembiochem (2014) 0.79
Prions: En route from structural models to structures. Prion (2010) 0.78
Identification of an amyloid fibril forming segment of human Pmel17 repeat domain (RPT domain). Biopolymers (2016) 0.77
Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils. J Am Chem Soc (2016) 0.77