Published in Nature on November 24, 1988
Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A (1990) 10.40
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A (1989) 7.79
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol (1990) 7.27
Nitric oxide synthases in mammals. Biochem J (1994) 6.50
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A (1989) 6.08
Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci U S A (1991) 3.67
The effects of L-arginine and NG-monomethyl L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br J Pharmacol (1989) 3.50
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24
Concepts of neural nitric oxide-mediated transmission. Eur J Neurosci (2008) 3.08
Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest (1991) 3.00
EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci U S A (1990) 2.94
L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol (1990) 2.84
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proc Natl Acad Sci U S A (1991) 2.64
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A (1991) 2.58
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol (1991) 2.53
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med (1989) 2.49
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A (1993) 2.46
Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg (1991) 2.24
Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J (1996) 2.13
L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol (1990) 2.12
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci U S A (1993) 2.10
Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J Clin Invest (1992) 2.08
Carboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci U S A (1997) 2.05
Kinetic characteristics of nitric oxide synthase from rat brain. Biochem J (1990) 2.00
Nitric oxide produced during murine listeriosis is protective. Infect Immun (1994) 1.93
What is the real physiological NO concentration in vivo? Nitric Oxide (2009) 1.88
Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol (1996) 1.87
Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev (2004) 1.87
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J (1990) 1.85
A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron (2007) 1.83
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med (1990) 1.81
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg (1990) 1.74
Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. Proc Natl Acad Sci U S A (1997) 1.73
The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest (1998) 1.66
Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. Proc Natl Acad Sci U S A (1996) 1.66
Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. J Exp Med (1990) 1.62
Modulation of an electrical synapse between solitary pairs of catfish horizontal cells by dopamine and second messengers. J Physiol (1989) 1.61
L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br J Pharmacol (1990) 1.61
Nitric oxide mediates norepinephrine-induced prostaglandin E2 release from the hypothalamus. Proc Natl Acad Sci U S A (1992) 1.60
The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. Proc Natl Acad Sci U S A (1990) 1.56
Nitric oxide in excitable tissues: physiological roles and disease. J Clin Invest (1997) 1.49
Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses. Proc Natl Acad Sci U S A (2000) 1.49
A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest (1991) 1.49
NO as a signalling molecule in the nervous system. Br J Pharmacol (2002) 1.46
Hypoxia-ischemia and retinal ganglion cell damage. Clin Ophthalmol (2008) 1.44
Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide. Nature (1998) 1.44
St Cyres lecture. Endothelium in control. Br Heart J (1991) 1.43
Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro. Proc Natl Acad Sci U S A (1993) 1.42
Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation. Br J Cancer (1994) 1.39
Effect of nitric oxide on circular muscle of the canine small intestine. J Physiol (1991) 1.34
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis. Br J Pharmacol (1994) 1.28
Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc Natl Acad Sci U S A (1993) 1.25
Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ (2011) 1.25
Induction and activity of NO synthase in bone-marrow-derived macrophages are independent of Ca2+. Biochem J (1990) 1.24
Critical role of nitric oxide-cGMP cascade in the formation of cAMP-dependent long-term memory. Learn Mem (2006) 1.22
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor. Proc Natl Acad Sci U S A (1993) 1.21
In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. Infect Immun (1992) 1.21
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nat Rev Drug Discov (2011) 1.21
Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation. Proc Natl Acad Sci U S A (1994) 1.20
Nitric oxide mediates sexual behavior in female rats. Proc Natl Acad Sci U S A (1994) 1.20
Evidence for nitric oxide as mediator of non-adrenergic non-cholinergic relaxations induced by ATP and GABA in the canine gut. Br J Pharmacol (1991) 1.20
The specific role of cGMP in hippocampal LTP. Learn Mem (1999) 1.19
Bioassay of nitric oxide released upon stimulation of non-adrenergic non-cholinergic nerves in the canine ileocolonic junction. Br J Pharmacol (1991) 1.17
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis (2010) 1.16
Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest (1990) 1.16
Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability. Neuron (2011) 1.16
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. Br J Pharmacol (1992) 1.14
Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurones of the rat paraventricular nucleus. J Physiol (1997) 1.14
Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol (2010) 1.13
Nitric oxide in health and disease of the nervous system. Antioxid Redox Signal (2009) 1.13
Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation. J Neural Transm (Vienna) (2011) 1.12
Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances. ACS Chem Biol (2011) 1.12
Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci U S A (1991) 1.12
Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design. Proc Natl Acad Sci U S A (2004) 1.11
The shaping of nitric oxide signals by a cellular sink. J Physiol (2001) 1.11
The role of nitric oxide in pre-synaptic plasticity and homeostasis. Front Cell Neurosci (2013) 1.11
Production and physiological effects of hydrogen sulfide. Antioxid Redox Signal (2013) 1.11
Adventures in vascular biology: a tale of two mediators. Philos Trans R Soc Lond B Biol Sci (2006) 1.10
Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man. J Physiol (1992) 1.10
Nitric oxide. Novel biology with clinical relevance. Ann Surg (1995) 1.09
Effects of NG-substituted analogues of L-arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscles and the bovine penile artery. Br J Pharmacol (1991) 1.08
Retrograde signaling at central synapses. Proc Natl Acad Sci U S A (2001) 1.08
Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Proc Natl Acad Sci U S A (1992) 1.08
Endogenous nitric oxide as a modulator of rabbit skeletal muscle microcirculation in vivo. Br J Pharmacol (1990) 1.08
The expression of contextual fear conditioning involves activation of an NMDA receptor-nitric oxide pathway in the medial prefrontal cortex. Cereb Cortex (2007) 1.07
Conversion of inhaled nitric oxide to nitrate in man. Br J Pharmacol (1995) 1.06
Emerging role of protein-protein transnitrosylation in cell signaling pathways. Antioxid Redox Signal (2012) 1.06
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link? Pflugers Arch (2004) 1.05
Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol (2012) 1.02
Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat. Psychopharmacology (Berl) (2008) 1.02
Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo. Br J Pharmacol (2000) 1.02
Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest (1999) 1.01
Modulation of cholinergic and substance P-like neurotransmission by nitric oxide in the guinea-pig ileum. Br J Pharmacol (1993) 1.01
Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols. Br J Pharmacol (1994) 1.00
Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. Cell Calcium (2010) 1.00
Dynamic properties of nitric oxide release from parallel fibres in rat cerebellar slices. J Physiol (1997) 1.00
S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal (2011) 1.00
Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain. Br J Pharmacol (1995) 0.98
Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci (1991) 4.66
Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol (2000) 1.69
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice. J Physiol (2007) 1.57
5-Hydroxytryptamine-induced potentiation of cholinergic responses to electrical field stimulation in pig detrusor muscle. BJU Int (2000) 1.38
Which muscarinic receptor is important in the bladder? World J Urol (2001) 1.06
The role of M(2)-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro. Br J Pharmacol (2000) 1.06
In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol (1999) 1.05
The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes. Br J Pharmacol (1997) 1.03
Urothelium derived inhibitory factor and cross-talk among receptors in the trigone of the bladder of the pig. J Urol (2002) 0.96
Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts? Br J Pharmacol (2008) 0.92
Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder. Auton Autacoid Pharmacol (2006) 0.87
M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro. J Auton Pharmacol (2000) 0.86
Investigation of neurokinin-2 and -3 receptors in the human and pig bladder. BJU Int (2003) 0.85
Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens. Br J Pharmacol (1995) 0.85
The nitric oxide-cyclic GMP pathway and synaptic plasticity in the rat superior cervical ganglion. Br J Pharmacol (1996) 0.82
Enhanced alpha-adrenoceptor responsiveness and receptor number during global ischaemia in the Langendorff perfused rat heart. Br J Pharmacol (1990) 0.82
Alpha 1B-adrenoceptor subtype mediating the phenylephrine-induced contractile response in rabbit corpus cavernosum penis. Jpn J Pharmacol (1996) 0.81
Relaxant effects of potassium-channel openers on normal and hyper-reflexic detrusor muscle. Br J Urol (1997) 0.81
Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter. Br J Pharmacol (2008) 0.81
Actions of 8-bromo-cyclic-GMP on neurones in the rat thalamus in vivo and in vitro. Brain Res (1999) 0.81
The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol (1994) 0.81
Amiodarone, adrenoceptor responsiveness and ischaemia- and reperfusion-induced arrhythmias. Eur J Pharmacol (1991) 0.81
The influence of 17-beta-oestradiol and the natural oestrous cycle on alpha-adrenoceptor-mediated responses of the cardiovascular system in the rat. J Pharm Pharmacol (1995) 0.80
Potential therapeutic targets for treatment of the overactive bladder. World J Urol (2001) 0.80
Non-adrenergic, non-cholinergic, non-purinergic contractions of the urothelium/lamina propria of the pig bladder. Auton Autacoid Pharmacol (2012) 0.79
The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones: is biliary colic muscular in origin? Scand J Gastroenterol (1999) 0.79
Pharmacology of the internal anal sphincter and its relevance to faecal incontinence. Auton Autacoid Pharmacol (2009) 0.79
Serotonin-induced potentiation of cholinergic responses to electrical field stimulation in normal and neurogenic overactive human detrusor muscle. BJU Int (2004) 0.78
Active relaxation of human gallbladder muscle is mediated by ATP-sensitive potassium channels. Digestion (2002) 0.78
Characterization of the alpha 1-adrenoceptors of the rat prostate gland. J Pharm Pharmacol (1993) 0.78
Potentiation of alpha-adrenoceptor-mediated responses following chronic beta-adrenoceptor stimulation in the rat heart. Br J Pharmacol (1993) 0.78
Alterations in acetylcholine, PGE2 and IL6 release from urothelial cells following treatment with pyocyanin and lipopolysaccharide. Toxicol In Vitro (2013) 0.78
Transient elevation of cardiac beta-adrenoceptor responsiveness and receptor number in the streptozotocin-diabetic rat. J Auton Pharmacol (1992) 0.78
Alpha(1A/L)-adrenoceptors mediate contraction of the circular smooth muscle of the pig urethra. Auton Autacoid Pharmacol (2006) 0.78
Diabetes-induced changes in cardiac beta-adrenoceptor responsiveness: effects of aldose reductase inhibition with ponalrestat. Br J Pharmacol (1991) 0.78
Lack of neuropeptide Y receptor detection in human bladder and prostate. BJU Int (2000) 0.77
Demonstration of 5-HT(3) receptor function and expression in the mouse bladder. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.77
The effect of streptozotocin-induced diabetes on cardiac beta-adrenoceptor subtypes in the rat. J Auton Pharmacol (2001) 0.77
The effects of streptozotocin-induced diabetes and aldose reductase inhibition with sorbinil, on left and right atrial function in the rat. J Pharm Pharmacol (2000) 0.76
In vitro contractility of stimulated and non-stimulated human gallbladder muscle. Neurogastroenterol Motil (1996) 0.76
In vitro responses of gallbladder muscle from patients with acalculous biliary pain. Digestion (2000) 0.76
The effect of local application of chlorhexidine on plaque and gingivitis. N Z Dent J (1996) 0.75
The in-vitro effects of insulin and the effects of acute fasting on cardiac beta-adrenoceptor responses in the short-term streptozotocin-diabetic rat. J Pharm Pharmacol (1994) 0.75
Influence of adrenoceptor stimulation on aggregation of platelets from diabetic and control rats. J Auton Pharmacol (1995) 0.75
The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats. J Auton Pharmacol (2000) 0.75
Functional and radioligand binding characterization of the α1L-adrenoceptor subtype of the human vas deferens. Auton Autacoid Pharmacol (2015) 0.75
Latest developments in the field of neurotransmitters. Eur Urol (1998) 0.75