Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

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🔗 View Article (PMID 29049607)

Published in JAMA Oncol on October 12, 2017

Authors

Ovarian Tumor Tissue Analysis (OTTA) Consortium, Ellen L Goode¹, Matthew S Block², Kimberly R Kalli², Robert A Vierkant¹, Wenqian Chen³, Zachary C Fogarty¹, Aleksandra Gentry-Maharaj⁴, Aleksandra Toloczko⁵, Alexander Hein⁶, Aliecia L Bouligny¹^,7, Allan Jensen⁸, Ana Osorio⁹^,10, Andreas D Hartkopf¹¹, Andy Ryan⁴, Anita Chudecka-Glaz¹², Anthony M Magliocco¹³, Arndt Hartmann¹⁴, Audrey Y Jung¹⁵, Bo Gao¹⁶^,17, Brenda Y Hernandez¹⁸, Brooke L Fridley¹⁹, Bryan M McCauley¹, Catherine J Kennedy¹⁶^,20, Chen Wang¹, Chloe Karpinskyj⁴, Christiani B de Sousa²¹, Daniel G Tiezzi²¹, David L Wachter¹⁴, Esther Herpel²², Florin Andrei Taran¹¹, Francesmary Modugno²³^,24^,25, Gregg Nelson²⁶, Jan Lubinski⁵, Janusz Menkiszak¹², Jennifer Alsop²⁷, Jenny Lester²⁸, Jesús García-Donas²⁹, Jill Nation²⁶, Jillian Hung¹⁶^,20, José Palacios³⁰, Joseph H Rothstein³¹, Joseph L Kelley²³, Jurandyr M de Andrade²¹, Luis Robles-Díaz³², Maria P Intermaggio³³, Martin Widschwendter⁴, Matthias W Beckmann⁶, Matthias Ruebner⁶, Mercedes Jimenez-Linan³⁴, Naveena Singh³⁵, Oleg Oszurek⁵, Paul R Harnett¹⁶^,17, Peter F Rambau³^,36, Peter Sinn³⁷, Philipp Wagner¹¹, Prafull Ghatage²⁶, Raghwa Sharma³⁸^,39, Robert P Edwards²³, Roberta B Ness⁴⁰, Sandra Orsulic²⁸, Sara Y Brucker¹¹, Sharon E Johnatty⁴¹, Teri A Longacre⁴², Ursula Eilber¹⁵, Valerie McGuire⁴³, Weiva Sieh³¹, Yanina Natanzon¹, Zheng Li¹^,44, Alice S Whittemore⁴⁵, Anna deFazio¹⁶^,20, Annette Staebler⁴⁶, Beth Y Karlan²⁸, Blake Gilks⁴⁷, David D Bowtell⁴⁸^,49^,50, Estrid Høgdall⁸^,51, Francisco J Candido Dos Reis²¹, Helen Steed⁵², Ian G Campbell⁵³^,54^,55, Jacek Gronwald⁵, Javier Benítez⁹^,10, Jennifer M Koziak⁵⁶, Jenny Chang-Claude¹⁵^,57, Kirsten B Moysich⁵⁸, Linda E Kelemen⁵⁹, Linda S Cook⁶⁰, Marc T Goodman⁶¹, María José García⁹^,10, Peter A Fasching⁶^,62, Stefan Kommoss¹¹, Suha Deen⁶³, Susanne K Kjaer⁸^,64, Usha Menon⁴, James D Brenton⁶⁵^,66^,67, Paul D P Pharoah²⁷^,68, Georgia Chenevix-Trench⁴¹, David G Huntsman⁶⁹^,70, Stacey J Winham¹, Martin Köbel³, Susan J Ramus³³^,50

Author Affiliations

1: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
2: Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
3: Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
4: Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, England.
5: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
6: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Germany.
7: Department of Health Sciences, Spelman College, Atlanta, Georgia.
8: Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
9: Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
10: Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
11: Tübingen University Hospital, Department of Women's Health, Tübingen, Germany.
12: Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
13: Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida.
14: Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
15: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
16: Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
17: The Crown Princess Mary Cancer Centre, Westmead Hospital, The University of Sydney, Australia.
18: Cancer Center, University of Hawaii, Honolulu.
19: Department of Biostatistics and Bioinformatics, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida.
20: Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
21: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
22: Tissue Bank of the National Center for Tumor Diseases (NCT) Heidelberg, Germany and Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
23: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
24: Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
25: Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
26: Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
27: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, England.
28: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
29: Medical Oncology Service, HM Hospitales-Centro Integral Oncológico HM Clara Campal, Madrid, Spain.
30: Department of Pathology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain.
31: Department of Population Health Science and Policy and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
32: Familial Cancer Unit and Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
33: School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
34: Department of Histopathology, Addenbrookes Hospital, Cambridge, England.
35: Department of Pathology, Barts Health National Health Service Trust, London, England.
36: Department of Pathology, Catholic University of Health and Allied Sciences-Bugando, Mwanza, Tanzania.
37: Department of Pathology, Institute of Pathology, Heidelberg University Hospital, Germany.
38: Pathology West ICPMR Westmead, Westmead Hospital, The University of Sydney, Sydney, Australia.
39: University of Western Sydney at Westmead Hospital, Westmead, New South Wales, Australia.
40: University of Texas School of Public Health, Houston.
41: Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
42: Department of Pathology, Stanford University, Stanford, California.
43: Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California.
44: Department of Gynecologic Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, China.
45: Department of Health Research and Policy and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California.
46: Tübingen University Hospital, Institute of Pathology, Tübingen, Germany.
47: Genetic Pathology Evaluation Centre, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
48: Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
49: Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
50: The Garvan Institute, Sydney, New South Wales, Australia.
51: Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
52: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Royal Alexandra Hospital, Edmonton, Alberta, Canada.
53: Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia.
54: Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia.
55: Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
56: Alberta Health Services-Cancer Care, Calgary, Alberta, Canada.
57: University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
58: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
59: Department of Public Health Sciences, Medical University of South Carolina and Hollings Cancer Center, Charleston.
60: Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque.
61: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
62: David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles.
63: Department of Histopathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, England.
64: Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
65: Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, England.
66: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, England.
67: Cambridge Experimental Cancer Medicine Centre, Cambridge, England.
68: Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England.
69: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
70: Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.