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The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol (2012) 6.20

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation (2008) 5.97

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28

Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification. J Clin Oncol (2006) 4.35

The coagulopathy of trauma: a review of mechanisms. J Trauma (2008) 4.02

European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. Resuscitation (2005) 3.99

Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol (2008) 3.71

Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65

Principles of pediatric emergency care. Dtsch Arztebl Int (2009) 3.14

Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09

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Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury (2007) 3.04

Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82

The quality of emergency medical care in baden-württemberg (Germany): four years in focus. Dtsch Arztebl Int (2010) 2.74

Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation (2008) 2.63

The long-distance tertiary air transfer and care of tsunami victims: injury pattern and microbiological and psychological aspects. Crit Care Med (2005) 2.62

Part 4: Advanced Life Support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2015) 2.32

Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 2.31

International perspectives on emergency department crowding. Acad Emerg Med (2011) 2.29

Emergency trauma score: an instrument for early estimation of trauma severity. Crit Care Med (2009) 2.24

Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma (2006) 2.15

Advanced trauma life support, 8th edition, the evidence for change. J Trauma (2008) 2.07

Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge. J Trauma Acute Care Surg (2013) 2.06

Effects of thrombolysis during out-of-hospital cardiopulmonary resuscitation. Am J Cardiol (2005) 2.05

Prospective case-control study on the etiopathology of Kienböck disease. Plast Reconstr Surg (2014) 2.05

Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease. J Am Coll Cardiol (2004) 2.03

Improvement in glottic visualisation by using the C-MAC PM video laryngoscope as a first-line device for out-of-hospital emergency tracheal intubation: An observational study. Eur J Anaesthesiol (2015) 2.01

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation. Neurology (2013) 1.98

Comparison of two intraosseous infusion systems for adult emergency medical use. Resuscitation (2008) 1.97

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet (2012) 1.96

The diagnosis and treatment of acute pulmonary embolism. Dtsch Arztebl Int (2010) 1.96

Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope (2009) 1.93

The ongoing variability in blood transfusion practices in cardiac surgery. Transfusion (2008) 1.90

Comparison of different video laryngoscopes for emergency intubation in a standardized airway manikin with immobilized cervical spine by experienced anaesthetists. A randomized, controlled crossover trial. Resuscitation (2011) 1.87

The C-MAC videolaryngoscope for prehospital emergency intubation: a prospective, multicentre, observational study. Emerg Med J (2011) 1.84

A randomised trial of a geriatric evaluation and management consultation services in frail hospitalised patients. Age Ageing (2007) 1.82

CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron (2009) 1.79

The Shock Index revisited - a fast guide to transfusion requirement? A retrospective analysis on 21,853 patients derived from the TraumaRegister DGU. Crit Care (2013) 1.77

Part 8: Advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 1.72

Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res (2009) 1.71

Epidemiology and risk factors of sepsis after multiple trauma: an analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery. Crit Care Med (2011) 1.71

Function of Nicotiana tabacum aquaporins as chloroplast gas pores challenges the concept of membrane CO2 permeability. Plant Cell (2008) 1.69

Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia. N Engl J Med (2015) 1.68

Electric current through a molecular rod-relevance of the position of the anchor groups. Angew Chem Int Ed Engl (2003) 1.67

The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery. Anesth Analg (2004) 1.66

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol (2008) 1.64

Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis. Crit Care (2011) 1.54

Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys (2008) 1.50

Assessment of hypovolaemic shock at scene: is the PHTLS classification of hypovolaemic shock really valid? Emerg Med J (2013) 1.48

Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies. Blood (2002) 1.47

Glasgow Coma Scale as a predictor for hemocoagulative disorders after blunt pediatric traumatic brain injury. Pediatr Crit Care Med (2012) 1.45

The impact of Trendelenburg position and positive end-expiratory pressure on the internal jugular cross-sectional area. Anesth Analg (2010) 1.43

German multicenter real-world registry of stenting for superficial femoral artery disease: clinical results and predictive factors for revascularization. J Endovasc Ther (2014) 1.43

Dose effects and image quality: is there any influence by bearing devices in whole-body computed tomography in trauma patients? Injury (2013) 1.43

Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol (2010) 1.43

A single-molecule diode. Proc Natl Acad Sci U S A (2005) 1.43

Antagonistic activity of bacteria isolated from organic aggregates of the German Wadden Sea. FEMS Microbiol Ecol (2004) 1.42

Effects of the application of erythropoietin on cerebral recovery after cardiac arrest in rats. Resuscitation (2007) 1.40

Image-guided spine surgery: state of the art and future directions. Eur Spine J (2009) 1.40

Oligonucleotide array-based comparative genomic hybridization (aCGH) of 90 neuroblastomas reveals aberration patterns closely associated with relapse pattern and outcome. Genes Chromosomes Cancer (2006) 1.38

Symptom-oriented follow-up of early breast cancer is not inferior to conventional control. Results of a prospective multicentre study. Onkologie (2007) 1.38

Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol (2012) 1.37

German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. Ann Neurol (2002) 1.32

The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome. Clin Cancer Res (2004) 1.30

Part 8: Advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation (2010) 1.30

A national resuscitation registry of out-of-hospital cardiac arrest in Germany-a pilot study. Resuscitation (2008) 1.28

A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients. Proc Natl Acad Sci U S A (2007) 1.27

Reduction in mortality of severely injured patients in Germany. Dtsch Arztebl Int (2008) 1.25

Characterization of a collection of Enterobacter sakazakii isolates from environmental and food sources. Int J Food Microbiol (2006) 1.22

Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU®. Crit Care (2013) 1.20

Assessing the enrichment performance in targeted resequencing experiments. Hum Mutat (2012) 1.20

The soluble NAD+-Reducing [NiFe]-hydrogenase from Ralstonia eutropha H16 consists of six subunits and can be specifically activated by NADPH. J Bacteriol (2005) 1.20

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proc Natl Acad Sci U S A (2013) 1.20

Predicting on-going hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithms on the TraumaRegister DGU. Crit Care (2012) 1.19

Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg (2007) 1.16

CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells. Cancer Res (2011) 1.16

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature. Clin Cancer Res (2010) 1.15

Determinants of life satisfaction in inflammatory bowel disease. Inflamm Bowel Dis (2005) 1.14

Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: a phase II study. Haematologica (2012) 1.14

Update of the trauma risk adjustment model of the TraumaRegister DGU™: the Revised Injury Severity Classification, version II. Crit Care (2014) 1.14

The definition of polytrauma revisited: An international consensus process and proposal of the new 'Berlin definition' J Trauma Acute Care Surg (2014) 1.13

Aquaporin tetramer composition modifies the function of tobacco aquaporins. J Biol Chem (2010) 1.13

Patient satisfaction and information gain after the preanesthetic visit: a comparison of face-to-face interview, brochure, and video. Anesth Analg (2005) 1.13

Cardiopulmonary resuscitation traumatic cardiac arrest--there are survivors. An analysis of two national emergency registries. Crit Care (2011) 1.13

Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma. Clin Cancer Res (2010) 1.12

Extracorporeal shock wave therapy in Peyronie's disease: results of a placebo-controlled, prospective, randomized, single-blind study. J Sex Med (2013) 1.11

Part 4: Advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation (2015) 1.11

Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced- intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study. Blood (2010) 1.10

Alcohol, cigarette smoking, dietary factors and the risk of colorectal adenomas and hyperplastic polyps--a case control study. Eur J Nutr (2002) 1.10

Functional aquaporin diversity in plants. Biochim Biophys Acta (2006) 1.10

Postoperative red blood cell transfusion and morbid outcome in uncomplicated cardiac surgery patients. Intensive Care Med (2010) 1.09

Diagnostic work-up of rectal bleeding in general practice. Br J Gen Pract (2005) 1.09

Radiotherapy for stages IIA/B testicular seminoma: final report of a prospective multicenter clinical trial. J Clin Oncol (2003) 1.08

Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis. Crit Care (2011) 1.08