Published in Nat Genet on October 07, 2012
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Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
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Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas. PLoS Genet (2014) 0.93
LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res (2013) 0.92
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev (2015) 0.91
MUC1-C drives MYC in multiple myeloma. Blood (2016) 0.91
Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children. J Cell Mol Med (2016) 0.90
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The Lin28/let-7 axis is critical for myelination in the peripheral nervous system. Nat Commun (2015) 0.88
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene (2014) 0.88
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A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B. Cancer Sci (2015) 0.81
Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas. Cancer Sci (2015) 0.81
Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila. Elife (2016) 0.81
Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations. Elife (2016) 0.80
Development and characterization of a human orthotopic neuroblastoma xenograft. Dev Biol (2015) 0.80
Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types. Nat Commun (2016) 0.80
The LIN28/let-7 Pathway in Cancer. Front Genet (2017) 0.79
The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res (2016) 0.79
The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis. Cancer Cell Int (2015) 0.79
Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells. Oncotarget (2015) 0.78
MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes. Oncotarget (2016) 0.78
LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19. Haematologica (2016) 0.78
Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma. Oncotarget (2015) 0.78
Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget (2016) 0.77
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma-differences in histological subtypes. BMC Cancer (2016) 0.77
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A (2015) 0.77
A cell-based high-throughput screen addressing 3'UTR-dependent regulation of the MYCN gene. Mol Biotechnol (2014) 0.77
MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma. Cancer Lett (2015) 0.77
LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1. Cancer Cell Int (2016) 0.76
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Lin28 and let-7 in cell metabolism and cancer. Transl Pediatr (2015) 0.76
Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives. Int J Mol Sci (2012) 0.76
Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget (2015) 0.76
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Editorial: Targeting MYCN in Pediatric Cancers. Front Oncol (2015) 0.75
Research progress of neuroblastoma related gene variations. Oncotarget (2016) 0.75
Redefining functional MYCN gene signatures in neuroblastoma. Proc Natl Acad Sci U S A (2012) 0.75
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Sex-specific regulation of weight and puberty by the Lin28/let-7 axis. J Endocrinol (2015) 0.75
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The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia (2016) 0.75
A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers. Hum Genet (2017) 0.75
Histone Deacetylases as New Therapeutic Targets in Triple-negative Breast Cancer: Progress and Promises. Cancer Genomics Proteomics (2017) 0.75
Identifying the miRNA signature associated with survival time in patients with lung adenocarcinoma using miRNA expression profiles. Sci Rep (2017) 0.75
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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
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Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
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Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev (2007) 3.46
Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet (2009) 3.09
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
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Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nat Genet (2009) 2.58
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
LIN28B promotes colon cancer progression and metastasis. Cancer Res (2011) 2.05
MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology (2010) 1.88
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LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Res (2011) 1.64
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. PLoS One (2011) 1.57
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Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma. Cancer Res (2008) 1.50
MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. Proc Natl Acad Sci U S A (2010) 1.49
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Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. Br J Cancer (2011) 1.37
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A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma. Cancer Res (2011) 1.23
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MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells. Oncogene (2012) 1.12
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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples. Clin Cancer Res (2011) 1.03
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