Published in Blood on October 01, 1986
Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. J Clin Invest (1988) 1.17
Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex. J Biol Chem (2010) 0.98
Pregnancy and vascular liver disease. J Clin Exp Hepatol (2015) 0.88
Thrombophilia in pregnancy. J Clin Pathol (2000) 0.87
The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system. Biochem J (1991) 0.86
Peripartum cardiomyopathy: current state of knowledge, new developments and future directions. Curr Cardiol Rev (2014) 0.85
Guidelines for the management of thrombophilia. Department of Haematology, The Royal London Hospital, Whitechapel, London, UK. Postgrad Med J (1996) 0.83
An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus. J Clin Invest (1992) 0.81
Vitamin K-dependent protein S in Leydig cells of human testis. Biochem J (1994) 0.80
Guidelines on the investigation and management of thrombophilia. The British Committee for Standards in Haematology. J Clin Pathol (1990) 0.77
The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C. J Matern Fetal Neonatal Med (2010) 0.77
Hemostatic profile in healthy premature neonates; does birth weight affect the coagulation profile? J Clin Neonatol (2014) 0.75
Consumption of C4b-binding protein (C4BP) during in vivo activation of the classical complement pathway. Clin Exp Immunol (1999) 0.75
Natural coagulation inhibitors and active protein c resistance in preeclampsia. Clinics (Sao Paulo) (2010) 0.75
The cost-benefit ratio of screening pregnant women for thrombophilia. Blood Transfus (2007) 0.75
Midventricular Obstructive Hypertrophic Cardiomyopathy during Pregnancy Complicated by Pulmonary Embolism: A Case Report. Case Rep Med (2012) 0.75
LPS-Toll-Like Receptor-Mediated Signaling on Expression of Protein S and C4b-Binding Protein in the Liver. Gastroenterol Res Pract (2010) 0.75
Association of complement receptor 2 polymorphisms with innate resistance to HIV-1 infection. Genes Immun (2015) 0.75
Changes in protein C and free protein S during pregnancy and following hysterectomy. J R Soc Med (1989) 0.75
New techniques for purifying large DNAs and studying their properties and packaging. Cold Spring Harb Symp Quant Biol (1983) 6.35
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med (2001) 4.10
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A (1981) 3.88
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem (1982) 3.51
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest (1987) 3.29
Conformation of promoter DNA: fine mapping of S1-hypersensitive sites. Cell (1983) 2.90
The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. Biochim Biophys Acta (1979) 2.83
Control of pain in adults with cancer: summary of SIGN guidelines. BMJ (2008) 2.72
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost (2005) 2.70
The regulation of natural anticoagulant pathways. Science (1987) 2.58
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A (1996) 2.58
The Preterm Prediction Study: association of cesarean delivery with increases in maternal weight and body mass index. Am J Obstet Gynecol (1997) 2.57
Leptospira species categorized by arbitrarily primed polymerase chain reaction (PCR) and by mapped restriction polymorphisms in PCR-amplified rRNA genes. J Bacteriol (1993) 2.53
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem (1994) 2.52
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost (2011) 2.51
Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci U S A (1986) 2.43
ABC of palliative care. Non-malignant conditions. BMJ (1998) 2.24
The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity. J Biol Chem (1979) 2.21
The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin. J Biol Chem (1974) 2.19
Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol (1980) 2.16
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem (1991) 2.14
The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody. J Biol Chem (1988) 2.06
Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem (1982) 2.04
Length polymorphisms in tRNA intergenic spacers detected by using the polymerase chain reaction can distinguish streptococcal strains and species. J Clin Microbiol (1992) 2.02
The preterm prediction study: effect of gestational age and cause of preterm birth on subsequent obstetric outcome. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol (1999) 2.01
Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med (1984) 1.98
Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood (1993) 1.97
Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem (1981) 1.94
DNA rehybridization during PCR: the 'Cot effect' and its consequences. Nucleic Acids Res (1996) 1.93
Sleep-disordered breathing and poor functional outcome after stroke. Stroke (1996) 1.90
Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol (1980) 1.90
The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network. Am J Public Health (1998) 1.90
The preterm prediction study: risk factors for indicated preterm births. Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development. Am J Obstet Gynecol (1998) 1.85
Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest (1984) 1.84
Screening for drinking disorders in the elderly using the CAGE questionnaire. J Am Geriatr Soc (1992) 1.83
Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation (1997) 1.81
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood (2000) 1.80
RNA fingerprinting and differential display using arbitrarily primed PCR. Trends Genet (1995) 1.78
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. J Biol Chem (1983) 1.77
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. J Biol Chem (1994) 1.77
Safety of labor epidural anesthesia for women with severe hypertensive disease. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol (1999) 1.75
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest (1987) 1.74
Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost (2007) 1.73
RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1. Proc Natl Acad Sci U S A (1993) 1.72
A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-CO3- into prothrombin. J Biol Chem (1975) 1.71
The rates of false-positive lumbar discography in select patients without low back symptoms. Spine (Phila Pa 1976) (2000) 1.71
Genetic analysis of the O7-polysaccharide biosynthesis region from the Escherichia coli O7:K1 strain VW187. J Bacteriol (1990) 1.69
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. J Thromb Haemost (2003) 1.67
Obstetric determinants of neonatal survival: antenatal predictors of neonatal survival and morbidity in extremely low birth weight infants. Am J Obstet Gynecol (1999) 1.66
A polypeptide region of bovine prothrombin specific for binding to phospholipids. Proc Natl Acad Sci U S A (1973) 1.65
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. J Biol Chem (1976) 1.64
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood (1989) 1.64
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem (1989) 1.63
Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemost (1991) 1.59
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem (1990) 1.59
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax (2008) 1.58
Vaginal and bladder angiosarcoma after therapeutic irradiation. South Med J (1989) 1.57
A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost (2001) 1.57
The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem (1996) 1.56
Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem (2000) 1.54
Vitamin K-dependent carboxylase. Requirements of the rat liver microsomal enzyme system. J Biol Chem (1976) 1.53
Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood (2001) 1.51
Activated protein C inhibits platelet prothrombin-converting activity. Blood (1979) 1.51
The preterm prediction study: a clinical risk assessment system. Am J Obstet Gynecol (1996) 1.51
Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest (1981) 1.50
Protein C activation following coronary artery occlusion in the in situ porcine heart. Circulation (1991) 1.50
The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. J Biol Chem (1992) 1.50
PFA-100 system: a new method for assessment of platelet dysfunction. Semin Thromb Hemost (1998) 1.48
Benefits of maternal corticosteroid therapy in infants weighing </=1000 grams at birth after preterm rupture of the amnion. Am J Obstet Gynecol (1999) 1.47
Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. Proc Natl Acad Sci U S A (1991) 1.46
A 5.3-kb deletion including exon XIII of the protein S alpha gene occurs in two protein S-deficient families. Blood (1991) 1.45
The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem (1991) 1.44
The natural anticoagulant protein S is decreased in male smokers. Am Heart J (1991) 1.41
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol Cell Biol (2000) 1.40
Value of molecular epidemiologic analysis in a nosocomial methicillin-resistant Staphylococcus aureus outbreak. JAMA (1993) 1.40
Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies. The National institute of Child health and Human Development Maternal- Fetal Medicine Units Network. Am J Obstet Gynecol (2000) 1.39
Inflammation, innate immunity and blood coagulation. Hamostaseologie (2010) 1.39
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood (1991) 1.36
The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem (1987) 1.36
The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype. J Thromb Haemost (2006) 1.34
An abnormal plasma distribution of protein S occurs in functional protein S deficiency. Blood (1986) 1.33
Thrombomodulin blocks the ability of thrombin to activate platelets. J Biol Chem (1983) 1.33
The Preterm Prediction Study: prediction of preterm premature rupture of membranes through clinical findings and ancillary testing. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol (2000) 1.31
The regulation of hemostasis: the protein C system. N Engl J Med (1986) 1.31
Identification of functional endothelial protein C receptor in human plasma. J Clin Invest (1997) 1.31
Protein C. Prog Hemost Thromb (1984) 1.30
Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood (2000) 1.30
Obstetric determinants of neonatal survival: influence of willingness to perform cesarean delivery on survival of extremely low-birth-weight infants. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstet Gynecol (1997) 1.30
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem (2000) 1.29
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem (1996) 1.28
Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. J Thromb Haemost (2009) 1.28
Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. J Biol Chem (1999) 1.27