Published in Cell on December 01, 1983
Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA. Proc Natl Acad Sci U S A (1988) 3.52
Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J Virol (1987) 3.45
Poly(pyrimidine) . poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH. Nucleic Acids Res (1984) 2.55
The two embryonic U1 RNA genes of Xenopus laevis have both common and gene-specific transcription signals. EMBO J (1985) 2.52
Intramolecular DNA triplexes in supercoiled plasmids. Proc Natl Acad Sci U S A (1988) 2.37
Defining a bacteriophage T4 late promoter: bacteriophage T4 gene 55 protein suffices for directing late promoter recognition. Proc Natl Acad Sci U S A (1984) 2.07
S1-hypersensitive sites in eukaryotic promoter regions. Nucleic Acids Res (1984) 1.88
Activating transcription from single stranded DNA. Proc Natl Acad Sci U S A (1996) 1.87
Human U1 RNA genes contain an unusually sensitive nuclease S1 cleavage site within the conserved 3' flanking region. Proc Natl Acad Sci U S A (1984) 1.86
Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene. Proc Natl Acad Sci U S A (1989) 1.85
Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene. Mol Cell Biol (1987) 1.73
Possible structures of homopurine-homopyrimidine S1-hypersensitive sites. Nucleic Acids Res (1984) 1.67
An S1 nuclease-sensitive homopurine/homopyrimidine domain in the c-Ki-ras promoter interacts with a nuclear factor. Proc Natl Acad Sci U S A (1990) 1.64
Initiation of rolling-circle replication in pT181 plasmid: initiator protein enhances cruciform extrusion at the origin. Proc Natl Acad Sci U S A (1990) 1.56
Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease. Mol Cell Biol (1988) 1.54
An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene. Nucleic Acids Res (1985) 1.53
Structural polymorphism of homopurine--homopyrimidine sequences: the secondary DNA structure adopted by a d(GA.CT)22 sequence in the presence of zinc ions. EMBO J (1989) 1.50
A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation. Nucleic Acids Res (1989) 1.47
Altered DNA conformations detected by mung bean nuclease occur in promoter and terminator regions of supercoiled pBR322 DNA. Nucleic Acids Res (1985) 1.46
Yeast regulatory sequences preferentially adopt a non-B conformation in supercoiled DNA. Nucleic Acids Res (1987) 1.38
Endonuclease G: a (dG)n X (dC)n-specific DNase from higher eukaryotes. EMBO J (1987) 1.34
A DNA-binding factor in adult hematopoietic cells interacts with a pyrimidine-rich domain upstream from the human delta-globin gene. Proc Natl Acad Sci U S A (1991) 1.32
In vitro excision of adeno-associated virus DNA from recombinant plasmids: isolation of an enzyme fraction from HeLa cells that cleaves DNA at poly(G) sequences. Mol Cell Biol (1988) 1.26
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol (1990) 1.22
Discrete human dihydrofolate reductase gene transcripts present in polysomal RNA map with their 5' ends several hundred nucleotides upstream of the main mRNA start site. Mol Cell Biol (1985) 1.20
Human homologs of TU transposon sequences: polypurine/polypyrimidine sequence elements that can alter DNA conformation in vitro and in vivo. Mol Cell Biol (1986) 1.18
A human histone H4 gene exhibits cell cycle-dependent changes in chromatin structure that correlate with its expression. Proc Natl Acad Sci U S A (1985) 1.17
Topoisomer gel retardation: detection of anti-Z-DNA antibodies bound to Z-DNA within supercoiled DNA minicircles. Nucleic Acids Res (1988) 1.16
Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions. Mol Cell Biol (1984) 1.16
Efficient transformation by Prague A Rous sarcoma virus plasmid DNA requires the presence of cis-acting regions within the gag gene. J Virol (1987) 1.16
Mung bean nuclease cleavage of a dA + dT-rich sequence or an inverted repeat sequence in supercoiled PM2 DNA depends on ionic environment. Nucleic Acids Res (1984) 1.15
Compilation of DNA strand exchange sites for non-homologous recombination in somatic cells. Nucleic Acids Res (1988) 1.14
Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult beta A globin gene promoter. Nucleic Acids Res (1989) 1.13
Characterization of a supercoil-dependent S1 sensitive site 5' to the Drosophila melanogaster hsp 26 gene. Nucleic Acids Res (1986) 1.10
Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations. Proc Natl Acad Sci U S A (1988) 1.09
S1 nuclease sensitivity of a double-stranded telomeric DNA sequence. Nucleic Acids Res (1987) 1.09
A monoclonal antibody to triplex DNA binds to eucaryotic chromosomes. Nucleic Acids Res (1987) 1.08
Evidence for altered DNA conformations in the simian virus 40 genome: site-specific DNA cleavage by the chiral complex lambda-tris(4,7-diphenyl-1,10-phenanthroline)cobalt(III). Proc Natl Acad Sci U S A (1987) 1.05
Eukaryotic DNA topoisomerase I reaction is topology dependent. Nucleic Acids Res (1988) 1.03
Regulation of the function of eukaryotic DNA topoisomerase I: topological conditions for inactivity. Proc Natl Acad Sci U S A (1989) 1.00
The embryonic enhancer-binding protein SSAP contains a novel DNA-binding domain which has homology to several RNA-binding proteins. Mol Cell Biol (1995) 1.00
Reaction conditions affect the specificity of bromoacetaldehyde as a probe for DNA cruciforms and B-Z junctions. Nucleic Acids Res (1987) 0.95
Structure of RNA polymerase II promoters. Conformational alterations and template properties of circularized Saccharomyces cerevisiae GAL1-GAL10 divergent promoters. EMBO J (1986) 0.91
Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes. EMBO J (1985) 0.91
The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli. Nucleic Acids Res (2013) 0.90
Structural models for non-helical DNA. EMBO J (1986) 0.90
Actinomycin D facilitates transition of AT domains in molecules of sequence (AT)nAGCT(AT)n to a DNAse I detectable alternating structure. Nucleic Acids Res (1987) 0.90
Rat L (long interspersed repeated DNA) elements contain guanine-rich homopurine sequences that induce unpairing of contiguous duplex DNA. Proc Natl Acad Sci U S A (1988) 0.87
Torsional stress induces an S1 nuclease-hypersensitive site within the promoter of the Xenopus laevis oocyte-type 5S RNA gene. Proc Natl Acad Sci U S A (1985) 0.87
Purification of an oligo(dG).oligo(dC)-binding sea urchin nuclear protein, suGF1: a family of G-string factors involved in gene regulation during development. Mol Cell Biol (1994) 0.85
The histone H5 gene is flanked by S1 hypersensitive structures. Nucleic Acids Res (1984) 0.85
Agrobacterium T-DNA integration in Arabidopsis is correlated with DNA sequence compositions that occur frequently in gene promoter regions. Funct Integr Genomics (2005) 0.85
DNA synthesis arrest sites at the right terminus of rat long interspersed repeated (LINE or L1Rn) DNA family members. Nucleic Acids Res (1987) 0.84
Polypurine/polypyrimidine sequence elements of the murine homeo box loci, Hox-1, -2 and -3. Nucleic Acids Res (1987) 0.84
Complex structural behavior of oligopurine-oligopyrimidine sequence cloned within the supercoiled plasmid. Nucleic Acids Res (1989) 0.83
Rat prostatic binding protein: the complete sequence of the C2 gene and its flanking regions. Nucleic Acids Res (1987) 0.81
Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA. Nucleic Acids Res (1993) 0.80
Nick-translation of metaphase chromosomes: in vitro labeling of nuclease-hypersensitive regions in chromosomes. Proc Natl Acad Sci U S A (1985) 0.79
Dam methyltransferase sites located within the loop region of the oligopurine-oligopyrimidine sequences capable of forming H-DNA are undermethylated in vivo. Nucleic Acids Res (1990) 0.79
The pyrimidine/purine-biased region of the epidermal growth factor receptor gene is sensitive to S1 nuclease and may form an intramolecular triplex. Biochem J (1990) 0.78
Conformational DNA transition in the in vitro torsionally strained chicken beta-globin 5' region. Nucleic Acids Res (1986) 0.78
Actinomycin D induced DNase I hypersensitivity and asymmetric structure transmission in a DNA hexadecamer. Nucleic Acids Res (1991) 0.77
Molecular characterization of the 5' end of the rudimentary gene in Drosophila and analysis of three P element insertions. Nucleic Acids Res (1992) 0.76
Intermediate range effects in DNA. I: Low pH/stress induced conformational changes in the vicinity of an extruded d(AT)n.d(AT) in cruciform. Nucleic Acids Res (1988) 0.75
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res (1979) 21.96
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information. Annu Rev Biochem (1986) 11.03
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36
The evolution of genes: the chicken preproinsulin gene. Cell (1980) 10.25
A bacterial clone synthesizing proinsulin. Proc Natl Acad Sci U S A (1978) 10.23
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell (1983) 9.90
Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
Parental imprinting of the mouse insulin-like growth factor II gene. Cell (1991) 7.11
End labeling of enzymatically decapped mRNA. Nucleic Acids Res (1977) 6.58
New techniques for purifying large DNAs and studying their properties and packaging. Cold Spring Harb Symp Quant Biol (1983) 6.35
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res (1978) 5.99
Equity and health sector reforms: can low-income countries escape the medical poverty trap? Lancet (2001) 5.64
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol (1995) 4.52
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev (1997) 3.83
Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83
Construction and characterization of a normalized cDNA library. Proc Natl Acad Sci U S A (1994) 3.73
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet (1995) 3.72
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature (1991) 3.68
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J Biol Chem (1994) 3.65
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet (1995) 3.45
In vivo splicing products of the rabbit beta-globin pre-mRNA. Cell (1984) 3.35
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol (2001) 3.13
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev (1999) 3.02
A randomized controlled trial of exercise therapy for dizziness and vertigo in primary care. Br J Gen Pract (1998) 2.95
The structure and transcription of four linked rabbit beta-like globin genes. Cell (1979) 2.81
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73
Control of pain in adults with cancer: summary of SIGN guidelines. BMJ (2008) 2.72
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A (1993) 2.58
Leptospira species categorized by arbitrarily primed polymerase chain reaction (PCR) and by mapped restriction polymorphisms in PCR-amplified rRNA genes. J Bacteriol (1993) 2.53
Structure and evolution of a human erythroid transcription factor. Nature (1990) 2.47
Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature (1993) 2.45
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol (1985) 2.35
Emergency department sonography by emergency physicians. Am J Emerg Med (1989) 2.35
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
ABC of palliative care. Non-malignant conditions. BMJ (1998) 2.24
Pre-mRNA splicing and the nuclear matrix. Mol Cell Biol (1987) 2.22
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. Proc Natl Acad Sci U S A (1990) 2.22
Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol (1998) 2.17
Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol (1980) 2.16
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol (1996) 2.15
Sequence-dependent S1 nuclease hypersensitivity of a heteronomous DNA duplex. J Biol Chem (1986) 2.15
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13
Effects of an Igf1 gene null mutation on mouse reproduction. Mol Endocrinol (1996) 2.08
Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study. Br Heart J (1979) 2.06
Distinct roles for the two cGATA-1 finger domains. Mol Cell Biol (1992) 2.04
Length polymorphisms in tRNA intergenic spacers detected by using the polymerase chain reaction can distinguish streptococcal strains and species. J Clin Microbiol (1992) 2.02
Fractionation of low molecular weight DNA or RNA in polyacrylamide gels containing 98% formamide or 7 M urea. Methods Enzymol (1980) 1.98
Purification of the major GTP-binding proteins from human placental membranes. J Biol Chem (1986) 1.94
Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev (2001) 1.94
DNA rehybridization during PCR: the 'Cot effect' and its consequences. Nucleic Acids Res (1996) 1.93
GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development (1993) 1.91
Sleep-disordered breathing and poor functional outcome after stroke. Stroke (1996) 1.90
Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol (1980) 1.90
Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus. J Biol Chem (1996) 1.89
S1-hypersensitive sites in eukaryotic promoter regions. Nucleic Acids Res (1984) 1.88
"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene. Proc Natl Acad Sci U S A (1985) 1.87
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature (1991) 1.87
Teaching students in the community. BMJ (1994) 1.84
Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Nucleic Acids Res (1985) 1.84
Screening for drinking disorders in the elderly using the CAGE questionnaire. J Am Geriatr Soc (1992) 1.83
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol (1997) 1.80
RNA fingerprinting and differential display using arbitrarily primed PCR. Trends Genet (1995) 1.78
Structure and promoter activity of the gene for the erythroid transcription factor GATA-1. Proc Natl Acad Sci U S A (1991) 1.77
Cell-specified expression of a selectable hybrid gene. Proc Natl Acad Sci U S A (1984) 1.74
Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family. J Mol Biol (1986) 1.72
RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1. Proc Natl Acad Sci U S A (1993) 1.72
Use of a cDNA library for studies on evolution and developmental expression of the chorion multigene families. Cell (1979) 1.72
The rates of false-positive lumbar discography in select patients without low back symptoms. Spine (Phila Pa 1976) (2000) 1.71
Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mamm Genome (2000) 1.71
Early diagnosis of myocardial infarction by timed sequential enzyme measurements. Ann Clin Biochem (1988) 1.70
Genetic analysis of the O7-polysaccharide biosynthesis region from the Escherichia coli O7:K1 strain VW187. J Bacteriol (1990) 1.69
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics (1997) 1.68
Electrophoretic patterns of deadenylylated chorion and globin mRNAs. Proc Natl Acad Sci U S A (1975) 1.67
Possible structures of homopurine-homopyrimidine S1-hypersensitive sites. Nucleic Acids Res (1984) 1.67
The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev Biol (1996) 1.63
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs. Science (1992) 1.58
Modular regulation of cGATA-5 gene expression in the developing heart and gut. Dev Biol (2000) 1.57
The eggshell of insects: differentiation-specific proteins and the control of their synthesis and accumulation during development. Results Probl Cell Differ (1977) 1.56
The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein. J Biol Chem (1992) 1.52
Autonomous splicing and complementation of in vivo-assembled spliceosomes. J Cell Biol (1989) 1.49
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease. J Neurosci Res (1999) 1.48
Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei. Genes Dev (1989) 1.48
Minimal exon sequence requirements for efficient in vitro splicing of mono-intronic nuclear pre-mRNA. J Biol Chem (1987) 1.48