Published in Eur J Pharmacol on August 15, 1978
Chemical modulation of glycerolipid signaling and metabolic pathways. Biochim Biophys Acta (2014) 0.89
Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature (1966) 30.39
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol (1994) 3.85
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci (1981) 3.71
The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro. Cancer Res (1976) 3.52
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. J Pharmacol Exp Ther (1981) 3.47
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. Proc Natl Acad Sci U S A (1991) 2.37
The preparation and antimycotic properties of derivatives of 1-phenethylimidazole. J Med Chem (1969) 2.28
Ketoconazole -- a new broad spectrum orally active antimycotic. Experientia (1979) 2.24
Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem Soc Trans (1990) 2.22
Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity. J Virol (1990) 2.19
Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole. Arch Int Pharmacodyn Ther (1981) 2.00
Itraconazole, a new triazole that is orally active in aspergillosis. Antimicrob Agents Chemother (1984) 1.83
Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects. JAMA (1971) 1.81
Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. J Pharm Pharmacol (1978) 1.76
Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke (1989) 1.70
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol (1996) 1.65
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine. Arzneimittelforschung (1974) 1.65
Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models. Rev Infect Dis (1987) 1.64
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol (1995) 1.53
Licensed midwife-attended, out-of-hospital births in Washington state: are they safe? Birth (1994) 1.52
The antiinflammatory effects of ketoconazole. A comparative study with hydrocortisone acetate in a model using living and killed Staphylococcus aureus on the skin of guinea-pigs. J Am Acad Dermatol (1991) 1.52
A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res (1991) 1.51
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneimittelforschung (1974) 1.51
In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol (1988) 1.49
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorg Med Chem Lett (2001) 1.44
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother (1992) 1.42
Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection. Antimicrob Agents Chemother (1992) 1.41
Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses (1989) 1.38
The absolute configurations of the optical isomers of the broad spectrum anthelmintic tetramisole. Tetrahedron Lett (1967) 1.36
Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837). Antimicrob Agents Chemother (1989) 1.33
Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats. Arzneimittelforschung (1967) 1.33
The concept of selectivity in 5-HT receptor research. Eur J Pharmacol (1990) 1.32
Hepatic reactions during ketoconazole treatment. Am J Med (1983) 1.32
Identifying women at-risk for postpartum depression in the immediate postpartum period. Acta Psychiatr Scand (2004) 1.30
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate. Arzneimittelforschung (1974) 1.30
Biochemical profile of risperidone, a new antipsychotic. J Pharmacol Exp Ther (1988) 1.29
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol (2001) 1.29
Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468). Eur J Pharmacol (1982) 1.29
Domperidone, a novel and safe gastrokinetic anti-nauseant for the treatment of dyspepsia and vomiting. Arzneimittelforschung (1978) 1.28
Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharmacol Exp Ther (1985) 1.26
Etomidate, R-(+)-ethyl-1-( -methyl-benzyl)imidazole-5-carboxylate (R 16659), a potent, short-acting and relatively atoxic intravenous hypnotic agent in rats. Arzneimittelforschung (1971) 1.24
The biochemical mechanism of action of the antinematodal drug tetramisole. Biochem Pharmacol (1969) 1.24
Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method. J Med Chem (1998) 1.20
New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines. J Med Chem (1985) 1.20
Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist. J Cardiovasc Pharmacol (1988) 1.18
Intranasal pirodavir (R77,975) treatment of rhinovirus colds. Antimicrob Agents Chemother (1995) 1.18
Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine. Arzneimittelforschung (1968) 1.16
Benzetimide and its optical isomers. Arzneimittelforschung (1971) 1.15
Mechanisms of action of loperamide. Scand J Gastroenterol Suppl (1984) 1.15
Effect of cinnarizine on peripheral circulation in dogs. Eur J Pharmacol (1972) 1.11
Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. 3. Regional distribution of pimozide and of haloperidol in the dog brain. Arzneimittelforschung (1968) 1.11
Mode of action studies. Basis for the search of new antifungal drugs. Ann N Y Acad Sci (1988) 1.10
The biochemical mechanism of action of the anthelmintic drug tetramisole. Life Sci (1967) 1.08
In vivo pharmacology of astemizole, a new type of H1-antihistaminic compound. Arch Int Pharmacodyn Ther (1981) 1.08
Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites. J Biol Chem (1985) 1.08
Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues. Arch Int Pharmacodyn Ther (1973) 1.06
Pharmacokinetics of R 82913 in patients with AIDS or AIDS-related complex. Lancet (1991) 1.05
Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. Agents Actions (1982) 1.04
Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat. J Pharmacol Exp Ther (1994) 1.04
The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers. Mol Pharmacol (1988) 1.03
Results of a 10 week community based strength and balance training programme to reduce fall risk factors: a randomised controlled trial in 65-75 year old women with osteoporosis. Br J Sports Med (2001) 1.02
Does endothelin-1 mediate endothelium-dependent contractions during anoxia? J Cardiovasc Pharmacol (1989) 1.02
The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch Int Pharmacodyn Ther (1980) 1.01
Characterization of ecto-ATPase on human blood cells. A physiological role in platelet aggregation? Biochem Pharmacol (1993) 1.01
Experimental systemic dermatophytosis. J Invest Dermatol (1984) 1.01
Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination. Neuropharmacology (1980) 1.00
The GABA transporter and its inhibitors. Curr Med Chem (2000) 1.00
Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. CMAJ (2001) 1.00
The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats. Psychopharmacologia (1967) 0.99
Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes. Mycoses (1991) 0.99
Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker. Acta Ophthalmol (Copenh) (1989) 0.98
Treatment of experimental zygomycosis in guinea pigs with azoles and with amphotericin B. Chemotherapy (1989) 0.97
Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors. Prog Drug Res (2000) 0.97
The antipyretic effect of suprofen in rats with yeast-induced fever. Arzneimittelforschung (1975) 0.97
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. Bioorg Med Chem Lett (2001) 0.96
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem (1991) 0.96
Pharmacology of antidiarrheal drugs. Annu Rev Pharmacol Toxicol (1983) 0.96
R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis. Biochem Pharmacol (1990) 0.96
Pharmacology of the specific histamine H1-antagonist astemizole. Arzneimittelforschung (1983) 0.95
Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology (Berl) (1986) 0.94
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor. J Med Chem (1992) 0.93
Suramin analogs, divalent cations and ATP gamma S as inhibitors of ecto-ATPase. Naunyn Schmiedebergs Arch Pharmacol (1995) 0.93
Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators. Experientia (1977) 0.93
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther (1992) 0.93
The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug. Arzneimittelforschung (1970) 0.92
In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol Pharmacol (1992) 0.92
Unusual mechanism of hypotensive activity exerted by erytrho-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET-a1-4-piperidyl)-2-benzimidazolinone (R 28935). Arch Int Pharmacodyn Ther (1975) 0.92
Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU). Bioorg Med Chem Lett (2001) 0.92
Suprofen, a potent antagonist of acetic acid-induced writhing in rats. Arzneimittelforschung (1975) 0.92
A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties. J Med Chem (1990) 0.91
Oral treatment with ketoconazole in systemic candidosis of guinea-pigs: microbiology, hematology and histopathology. Sabouraudia (1985) 0.91
Evidence for functional 5-HT2 receptor sites on human blood platelets. Biochem Pharmacol (1984) 0.91
Factors regulating drug cue sensitivity: limits of discriminability and the role of a progressively decreasing training dose in fentanyl-saline discrimination. J Pharmacol Exp Ther (1980) 0.91
R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--I. Biochemical profile in vitro. Thromb Haemost (1989) 0.91
Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide. Arch Int Pharmacodyn Ther (1978) 0.90
Differential haloperidol effect on two indices of fentanyl-saline discrimination. Psychopharmacology (Berl) (1977) 0.90