Published in Curr Top Microbiol Immunol on January 01, 1985
Supercoiling of the DNA template during transcription. Proc Natl Acad Sci U S A (1987) 14.25
DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc Natl Acad Sci U S A (1988) 3.10
DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences. Proc Natl Acad Sci U S A (1988) 2.86
Changes in the linking number of supercoiled DNA accompany growth transitions in Escherichia coli. J Bacteriol (1987) 2.50
Topoisomerase I mutants: the gene on pBR322 that encodes resistance to tetracycline affects plasmid DNA supercoiling. Proc Natl Acad Sci U S A (1986) 2.45
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc Natl Acad Sci U S A (1985) 2.21
DNA binding by the archaeal histone HMf results in positive supercoiling. Proc Natl Acad Sci U S A (1991) 2.13
Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol Cell Biol (1988) 2.05
The C-terminal domain of the Escherichia coli DNA gyrase A subunit is a DNA-binding protein. Nucleic Acids Res (1991) 1.74
Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin. Mol Cell Biol (1987) 1.71
his operons of Escherichia coli and Salmonella typhimurium are regulated by DNA supercoiling. Proc Natl Acad Sci U S A (1987) 1.69
Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes. Proc Natl Acad Sci U S A (1989) 1.58
An unusual mechanism for resistance to the antibiotic coumermycin A1. Proc Natl Acad Sci U S A (1991) 1.57
Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proc Natl Acad Sci U S A (1995) 1.50
The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases. EMBO J (1986) 1.50
Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I. Proc Natl Acad Sci U S A (1989) 1.45
Mapping in vivo topoisomerase I sites on simian virus 40 DNA: asymmetric distribution of sites on replicating molecules. Mol Cell Biol (1989) 1.44
DNA topoisomerase I is essential in Drosophila melanogaster. Proc Natl Acad Sci U S A (1993) 1.44
Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D. Proc Natl Acad Sci U S A (1988) 1.44
Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli. Proc Natl Acad Sci U S A (1987) 1.41
Targeted disruption of the mouse topoisomerase I gene by camptothecin selection. Mol Cell Biol (1996) 1.37
Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J Cell Biol (1994) 1.36
DNA affinity labeling of adenovirus type 2 upstream promoter sequence-binding factors identifies two distinct proteins. Mol Cell Biol (1988) 1.27
Inhibition of DNA synthesis by aphidicolin induces supercoiling in simian virus 40 replicative intermediates. EMBO J (1985) 1.26
Inhibitory effects of quinolones on pro- and eucaryotic DNA topoisomerases I and II. Antimicrob Agents Chemother (1990) 1.25
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice. J Virol (1987) 1.23
Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replication in vivo. Nucleic Acids Res (1987) 1.15
DNA topoisomerase II cleaves at specific sites in the 5' flanking region of c-fos proto-oncogenes in vitro. EMBO J (1986) 1.11
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. Proc Natl Acad Sci U S A (1988) 1.11
The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells. J Cell Biol (1990) 1.09
DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation. Mol Cell Biol (1988) 1.05
Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans. Mol Cell Biol (1994) 1.05
Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature. Nucleic Acids Res (1991) 1.05
Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells. Proc Natl Acad Sci U S A (1987) 1.03
Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase. Proc Natl Acad Sci U S A (1986) 1.03
Topoisomerase I activity associated with human immunodeficiency virus (HIV) particles and equine infectious anemia virus core. EMBO J (1990) 1.02
Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin. EMBO J (1987) 1.02
Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.00
In vitro assays used to measure the activity of topoisomerases. Antimicrob Agents Chemother (1990) 0.98
Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. J Virol (1990) 0.96
Microinjection of anti-topoisomerase I immunoglobulin G into nuclei of Chironomus tentans salivary gland cells leads to blockage of transcription elongation. Mol Cell Biol (1987) 0.92
Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I. Antimicrob Agents Chemother (1987) 0.89
Characterisation of adriamycin- and amsacrine-resistant human leukaemic T cell lines. Br J Cancer (1991) 0.88
Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock gene. Nucleic Acids Res (1989) 0.88
Archaebacterial reverse gyrase cleavage-site specificity is similar to that of eubacterial DNA topoisomerases I. Nucleic Acids Res (1990) 0.87
Regulation of DNA superhelicity by rpoB mutations that suppress defective Rho-mediated transcription termination in Escherichia coli. J Bacteriol (1988) 0.87
Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms. Proc Natl Acad Sci U S A (1996) 0.85
DNA topoisomerase II activity in nonreplicating, transcriptionally inactive, chicken late spermatids. EMBO J (1989) 0.85
Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase. Nucleic Acids Res (1990) 0.84
Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells. Nucleic Acids Res (1990) 0.82
Yeast Saccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin. Cancer Chemother Pharmacol (1994) 0.82
In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles. Mol Cell Biol (1994) 0.82
Position-specific effect of ribonucleotides on the cleavage activity of human topoisomerase II. Nucleic Acids Res (2000) 0.81
Transient activation of topoisomerase I in leukotriene D4 signal transduction in human cells. Biochem J (1990) 0.81
Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I. Nucleic Acids Res (1993) 0.81
Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother (2002) 0.80
Distamycin inhibition of topoisomerase I-DNA interaction: a mechanistic analysis. Nucleic Acids Res (1990) 0.80
Step-wise DNA relaxation and decatenation by NaeI-43K. Nucleic Acids Res (1998) 0.80
Stimulation of intracellular topoisomerase I activity by vasopressin and thrombin. Differential regulation by pertussis toxin. Biochem J (1989) 0.80
Effects of VM26, a specific inhibitor of type II DNA topoisomerase, on SV40 chromatin replication in vitro. Nucleic Acids Res (1988) 0.80
Purification and characterization of a proteolytic active fragment of DNA topoisomerase I from the brine shrimp Artemia franciscana (Crustacea Anostraca). Biochem J (1992) 0.79
Ellipticine increases the superhelical density of intracellular SV40 DNA by intercalation. Nucleic Acids Res (1992) 0.76
Activation of cAMP-dependent protein kinase alters the chromatin structure of the urokinase-type plasminogen activator gene promoter. Nucleic Acids Res (1994) 0.75
Physical Proximity of Sister Chromatids Promotes Top2-Dependent Intertwining. Mol Cell (2016) 0.75
Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells. Cancer Chemother Pharmacol (1994) 0.75
Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: formation of a Boltzmann distribution of topological isomers. Proc Natl Acad Sci U S A (1975) 6.26
Incorporation of phosphorothioate groups into fd and phi X174 DNA. Biochemistry (1977) 6.10
A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell (1990) 5.77
DNA synthesis in nucleotide-permeable Escherichia coli cells. I. Preparation and properties of ether-treated cells. J Mol Biol (1971) 4.65
Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell (1994) 4.47
Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy. Nat Genet (1995) 2.52
Direct sequencing of polymerase chain reaction amplified DNA fragments through the incorporation of deoxynucleoside alpha-thiotriphosphates. Nucleic Acids Res (1988) 2.28
Isolation and partial characterisation of the relaxation protein from nuclei of cultured mouse and human cells. Eur J Biochem (1975) 2.27
A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell (1990) 1.92
The complete sequence of the human beta-myosin heavy chain gene and a comparative analysis of its product. Genomics (1990) 1.67
Purification and demonstration of the enzymatic character of the nicking-closing protein from mouse L cells. Biochem Biophys Res Commun (1976) 1.35
Enzymatic amplification of myosin heavy-chain mRNA sequences in vitro. DNA (1988) 1.34
Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I. Chromosoma (1986) 1.30
Analysis of covalent complexes formed between calf thymus DNA topoisomerase and single-stranded DNA. Eur J Biochem (1980) 1.30
A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. Circulation (2000) 1.26
Partial characterization of the human beta-myosin heavy-chain gene which is expressed in heart and skeletal muscle. Eur J Biochem (1986) 1.24
Relaxation of supercoiled phosphorothioate DNA by mammalian topoisomerases is inhibited in a base-specific manner. J Biol Chem (1985) 1.18
Exclusion of cardiac myosin heavy chain and actin gene involvement in hypertrophic cardiomyopathy of several French families. Circ Res (1992) 1.16
A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12. Am J Hum Genet (1990) 1.14
Effect of deoxynucleoside phosphorothioates incorporated in DNA on cleavage by restriction enzymes. J Biol Chem (1982) 1.12
DNA topoisomerase II cleaves at specific sites in the 5' flanking region of c-fos proto-oncogenes in vitro. EMBO J (1986) 1.11
Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene. J Am Coll Cardiol (1997) 0.99
A high risk phenotype of hypertrophic cardiomyopathy associated with a compound genotype of two mutated beta-myosin heavy chain genes. Hum Genet (1998) 0.93
DNA topoisomerase I from calf thymus is inhibited in vitro by poly(ADP-ribosylation). Eur J Biochem (1983) 0.92
Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation). EMBO J (1985) 0.92
Chromosomal localization of a human myosin heavy-chain gene by in situ hybridization. Hum Genet (1983) 0.91
Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone. Circ Res (1990) 0.90
Molecular cloning of DNA. An introduction into techniques and problems. Hum Genet (1977) 0.90
Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. Hum Genet (2000) 0.88
Intracellular distribution of DNA topoisomerase I in fibroblasts from patients with Fanconi's anaemia. Hum Genet (1982) 0.88
Characterisation of size variants of type I DNA topoisomerase isolated from calf thymus. Eur J Biochem (1984) 0.86
Expression of human beta-myosin heavy chain fragments in Escherichia coli; localization of actin interfaces on cardiac myosin. J Muscle Res Cell Motil (1990) 0.83
Analysis of a dystrophin gene deletion by amplification of mRNA isolated from DMD myotubes cultured in vitro. Genomics (1991) 0.82
Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Induction of DNA repair by the carcinogens methyl and ethyl nitrosourea and methyl methanesulfonate. Eur J Biochem (1975) 0.81
Isolation and characterization of the complete human beta-myosin heavy chain gene. Hum Genet (1989) 0.79
Apical hypertrophic cardiomyopathy due to a de novo mutation Arg719Trp of the beta-myosin heavy chain gene and cardiac arrest in childhood. A case report and family study. Z Kardiol (2000) 0.78
A novel missense mutation (R712L) adjacent to the "active thiol" region of the cardiac beta-myosin heavy chain gene causing hypertrophic cardiomyopathy in an Indian family. Hum Mutat (2000) 0.78
Mapping of the actomyosin interfaces. Proc Natl Acad Sci U S A (1994) 0.77
Identification of a mutation near a functional site of the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy. J Mol Cell Cardiol (1994) 0.76
A polymorphism of the MYH7 gene. Nucleic Acids Res (1990) 0.75
[Discontinuous synthesis of the 1st DNA complementary strand of phage phiX174]. Hoppe Seylers Z Physiol Chem (1972) 0.75
[The significance of gene technology for medicine]. Med Welt (1984) 0.75
[Gene technology in medicine]. Dtsch Med Wochenschr (1982) 0.75
Gene symbol: MYBPC3. Disease: Hypertrophic cardiomyopathy. Hum Genet (2004) 0.75
Some electron microscopic aspects of poly(ADPR) polymerase-DNA interactions and of auto-poly(ADP-ribosyl)ation reaction. Princess Takamatsu Symp (1983) 0.75
Proceedings: Carcinogen-induced DNA repair. Hoppe Seylers Z Physiol Chem (1974) 0.75
Characterization of a human genomic DNA fragment coding for a myosin heavy chain. Hum Genet (1983) 0.75
[Heart failure as genetic disease: exemplified by cardiomyopathy]. Internist (Berl) (1993) 0.75