Published in J Biol Chem on November 15, 1985
Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis. J Clin Invest (1987) 1.28
Na+-H+ exchange in luminal-membrane vesicles from rabbit proximal convoluted and straight tubules in response to metabolic acidosis. Biochem J (1986) 0.95
Transient state kinetic evidence for an oligomer in the mechanism of Na+-H+ exchange. Proc Natl Acad Sci U S A (1989) 0.88
A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule. J Gen Physiol (1995) 0.87
Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C. J Clin Invest (1994) 0.82
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature (1996) 8.63
A proton-gated cation channel involved in acid-sensing. Nature (1997) 6.98
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature (1992) 5.45
H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr Opin Neurobiol (1998) 3.80
Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci (1999) 3.73
TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J (1997) 3.60
A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J (1998) 3.58
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem (1997) 3.24
A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem (1997) 3.23
Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol (2000) 3.15
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J (1996) 3.08
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J (1996) 3.06
TREK-1, a K+ channel involved in neuroprotection and general anesthesia. EMBO J (2004) 2.85
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. J Biol Chem (2000) 2.85
TREK-1 is a heat-activated background K(+) channel. EMBO J (2000) 2.82
[3H]nitrendipine receptors in skeletal muscle. J Biol Chem (1983) 2.77
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J (1998) 2.55
Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem (1999) 2.55
Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett (1993) 2.52
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci (2001) 2.51
Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel. J Biol Chem (1994) 2.44
Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem (1998) 2.37
Inner ear defects induced by null mutation of the isk gene. Neuron (1996) 2.34
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature (1995) 2.32
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J (2000) 2.25
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. J Biol Chem (1987) 2.24
Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem (2000) 2.16
Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol (2002) 2.16
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem (1996) 2.15
Lipid and mechano-gated 2P domain K(+) channels. Curr Opin Cell Biol (2001) 2.12
Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett (1994) 2.10
The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc Natl Acad Sci U S A (1994) 2.09
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ (2010) 2.09
TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem (1999) 2.04
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor. Proc Natl Acad Sci U S A (1982) 2.01
Calcium channels: molecular pharmacology, structure and regulation. J Membr Biol (1988) 1.99
Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. J Biol Chem (1995) 1.98
The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. Biochem Biophys Res Commun (1984) 1.96
Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem Biophys Res Commun (1993) 1.93
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem (2000) 1.92
The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J (2001) 1.91
The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol (1985) 1.90
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. Mol Pharmacol (2000) 1.87
Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. EMBO J (1997) 1.84
Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem (1995) 1.80
Polyunsaturated fatty acids are potent neuroprotectors. EMBO J (2000) 1.80
Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol (1995) 1.79
Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. J Biol Chem (1997) 1.79
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J Biol Chem (1997) 1.76
Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges. Biochemistry (1972) 1.76
Zn2+ and H+ are coactivators of acid-sensing ion channels. J Biol Chem (2001) 1.73
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci U S A (1994) 1.73
Molecular mechanism of action of the vasoconstrictor peptide endothelin. Biochem Biophys Res Commun (1988) 1.72
Cloning and expression of a membrane receptor for secretory phospholipases A2. J Biol Chem (1994) 1.72
Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels. Science (1990) 1.72
Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sci (1999) 1.69
The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem (1988) 1.68
Flip-flop mechanisms in enzymology. A model: the alkaline phosphatase of Escherichia coli. Eur J Biochem (1971) 1.67
Different types of Ca2+ channels in mammalian skeletal muscle cells in culture. Proc Natl Acad Sci U S A (1986) 1.66
H(+)-gated cation channels. Ann N Y Acad Sci (1999) 1.66
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun (1995) 1.65
The role of the Na+/H+ exchange system in cardiac cells in relation to the control of the internal Na+ concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart. J Biol Chem (1984) 1.64
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning. Proc Natl Acad Sci U S A (1995) 1.62
Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels. J Biol Chem (1988) 1.61
The protein IsK is a dual activator of K+ and Cl- channels. Nature (1993) 1.61
Activation of the nuclear factor-kappaB is a key event in brain tolerance. J Neurosci (2001) 1.60
Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. J Thorac Cardiovasc Surg (1999) 1.57
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J (1996) 1.57
Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone. J Biol Chem (1994) 1.56
Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J (1997) 1.55
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol (2001) 1.54
New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem (1997) 1.52
The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. J Biol Chem (1994) 1.51
The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J Biol Chem (1995) 1.50
Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function. J Biol Chem (1995) 1.50
Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A (1988) 1.49
The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood (1998) 1.48
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes. J Biol Chem (1986) 1.47
Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Proc Natl Acad Sci U S A (1979) 1.43
Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci U S A (1995) 1.40
Intestinal alkaline phosphatase. Physical properties and quaternary structure. Biochemistry (1974) 1.39
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition. J Biol Chem (1985) 1.39
Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices. Brain Res (1989) 1.38
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis (2013) 1.37
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem (1999) 1.37