Published in EMBO J on December 16, 1985
Mitochondrial targeting sequences may form amphiphilic helices. EMBO J (1986) 7.11
Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol (2000) 2.62
Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol (1997) 2.44
Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. J Cell Biol (1991) 2.39
Targeting proteins into mitochondria. Microbiol Rev (1986) 2.36
Characterization of the signal that directs Tom20 to the mitochondrial outer membrane. J Cell Biol (2000) 2.16
Acyl-CoA oxidase contains two targeting sequences each of which can mediate protein import into peroxisomes. EMBO J (1988) 2.12
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Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. Mol Biol Cell (2002) 1.76
A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle. Mol Cell Biol (1991) 1.75
Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol (1990) 1.72
A signal-anchor sequence selective for the mitochondrial outer membrane. J Cell Biol (1992) 1.68
Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites. EMBO J (1987) 1.63
An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc Natl Acad Sci U S A (1999) 1.45
MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA. Mol Cell Biol (1991) 1.44
The cleavable pre-sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria. EMBO J (1986) 1.34
Sequences from a prokaryotic genome or the mouse dihydrofolate reductase gene can restore the import of a truncated precursor protein into yeast mitochondria. Proc Natl Acad Sci U S A (1987) 1.32
The signal that sorts yeast cytochrome b2 to the mitochondrial intermembrane space contains three distinct functional regions. EMBO J (1993) 1.29
cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme. EMBO J (1987) 1.26
Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell (1999) 1.25
Transport of proteins to the mitochondrial intermembrane space: the 'matrix-targeting' and the 'sorting' domains in the cytochrome c1 presequence. EMBO J (1987) 1.18
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A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes. J Cell Biol (1996) 1.18
A novel, bipartite transit peptide targets OEP75 to the outer membrane of the chloroplastic envelope. Plant Cell (1996) 1.17
Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments. Mol Cell Biol (1992) 1.14
Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol. Mol Cell Biol (1994) 1.10
Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence. Nucleic Acids Res (1986) 1.06
Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import. EMBO J (1987) 1.05
Amino-terminal extension generated from an upstream AUG codon increases the efficiency of mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferases. Mol Cell Biol (1989) 1.02
Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters. Proc Natl Acad Sci U S A (1987) 1.02
Targeting proteins to mitochondria: a current overview. Biochem J (1992) 1.00
Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encoded maturase. EMBO J (1987) 0.96
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The human mitochondrial import receptor, hTom20p, prevents a cryptic matrix targeting sequence from gaining access to the protein translocation machinery. J Cell Biol (1996) 0.90
MIP1, a new yeast gene homologous to the rat mitochondrial intermediate peptidase gene, is required for oxidative metabolism in Saccharomyces cerevisiae. Mol Cell Biol (1994) 0.89
Influence of N-terminal sequence variation on the sorting of major adenylate kinase to the mitochondrial intermembrane space in yeast. Biochem J (1998) 0.89
The role of topogenic sequences in the movement of proteins through membranes. Biochem J (1987) 0.86
The interaction of a synthetic mitochondrial signal peptide with lipid membranes is independent of transbilayer potential. EMBO J (1987) 0.86
Requirement of different mitochondrial targeting sequences of the yeast mitochondrial transcription factor Mtf1p when synthesized in alternative translation systems. Biochem J (2004) 0.82
Transport of the yeast ATP synthase beta-subunit into mitochondria. Effects of amino acid substitutions on targeting. Biochem J (1990) 0.81
Heterologous ferredoxin reductase and flavodoxin protect Cos-7 cells from oxidative stress. PLoS One (2010) 0.81
A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor. Am J Hum Genet (1995) 0.81
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Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J Biol Chem (1982) 12.07
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc Natl Acad Sci U S A (1982) 11.42
Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A (1984) 7.39
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. J Biol Chem (1982) 4.25
Spectrophotometric quantitation of silver grains eluted from autoradiograms. Anal Biochem (1983) 3.73
Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli. Nature (1975) 3.70
How are proteins imported into mitochondria? Cell (1983) 3.69
The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix. EMBO J (1984) 3.69
A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus. EMBO J (1984) 2.96
A leader peptide is sufficient to direct mitochondrial import of a chimeric protein. EMBO J (1985) 2.78
The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix. FEBS Lett (1984) 2.75
Cytochrome c oxidase from bakers' yeast. I. Isolation and properties. J Biol Chem (1973) 2.50
Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane. EMBO J (1983) 2.33
Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein. EMBO J (1984) 1.97
Import of proteins into mitochondria: nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane. EMBO J (1983) 1.97
Information within the mature LamB protein necessary for localization to the outer membrane of E coli K12. Cell (1983) 1.94
The cytoplasmically-made subunit IV is necessary for assembly of cytochrome c oxidase in yeast. EMBO J (1985) 1.75
Molecular cloning and sequencing of cDNA for yeast porin, an outer mitochondrial membrane protein: a search for targeting signal in the primary structure. EMBO J (1985) 1.67
In vitro synthesis and integration into mitochondria of porin, a major protein of the outer mitochondrial membrane of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1982) 1.62
Import of proteins into mitochondria. In vitro studies on the biogenesis of the outer membrane. J Biol Chem (1983) 1.51
Biosynthesis of mitochondrial porin and insertion into the outer mitochondrial membrane of Neurospora crassa. Eur J Biochem (1982) 1.37
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J Biol Chem (1982) 12.07
Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A (1984) 7.39
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Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature (1986) 5.58
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol (1999) 4.98
The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J (1991) 4.93
A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J (1989) 4.91
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. Cell (1993) 4.68
Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron (2001) 4.62
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science (1995) 4.59
Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet (2000) 4.55
A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell (1996) 4.37
Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. J Biol Chem (1982) 4.25
Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue. Am J Pathol (2001) 4.18
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol (1995) 4.16
Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13
Protein translocation across membranes. Science (1988) 4.12
Properties of avian retrovirus particles defective in viral protease. J Virol (1990) 4.03
Is the unitarity of the quark-mixing CKM matrix violated in neutron beta-decay? Phys Rev Lett (2002) 3.80
The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix. EMBO J (1984) 3.69
How are proteins imported into mitochondria? Cell (1983) 3.69
A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution. EMBO J (1994) 3.65
Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J (1999) 3.58
A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1. EMBO J (1992) 3.57
Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell (1992) 3.42
NSP1: a yeast nuclear envelope protein localized at the nuclear pores exerts its essential function by its carboxy-terminal domain. Cell (1990) 3.38
Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent. J Biol Chem (1982) 3.26
MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (1994) 3.17
Purification of NSP1 reveals complex formation with 'GLFG' nucleoporins and a novel nuclear pore protein NIC96. EMBO J (1993) 3.04
Immune defence in mice lacking type I and/or type II interferon receptors. Immunol Rev (1995) 2.97
A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus. EMBO J (1984) 2.96
A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. EMBO J (1986) 2.91
Nuclear pore proteins are involved in the biogenesis of functional tRNA. EMBO J (1996) 2.90
Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides. J Biol Chem (1983) 2.81
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80
A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell (1993) 2.80
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Transient and linear dichroism studies on bacteriorhodopsin: determination of the orientation of the 568 nm all-trans retinal chromophore. J Mol Biol (1977) 2.75
A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. EMBO J (1993) 2.71
Establishment of de novo DNA methylation patterns. Transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter. J Mol Biol (1990) 2.69
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein. EMBO J (1990) 2.56
Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins. EMBO J (1983) 2.55
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification. EMBO J (1994) 2.53
Cytochrome c oxidase from bakers' yeast. I. Isolation and properties. J Biol Chem (1973) 2.50
The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles. EMBO J (1983) 2.48
Import of proteins into mitochondria. Energy-dependent, two-step processing of the intermembrane space enzyme cytochrome b2 by isolated yeast mitochondria. J Biol Chem (1982) 2.46
Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell (1994) 2.45
A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts. Nucleic Acids Res (1986) 2.45
Immunogenicity of hepatitis B Vaccines. Implications for persons at occupational risk of hepatitis B virus infection. Am J Prev Med (1998) 2.41
Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. J Cell Biol (1991) 2.39
Imported mitochondrial proteins cytochrome b2 and cytochrome c1 are processed in two steps. Proc Natl Acad Sci U S A (1982) 2.39
Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria. Nature (1991) 2.37
Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p. EMBO J (1995) 2.35
Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptides. J Biol Chem (1982) 2.34
Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane. EMBO J (1983) 2.33
Isolation of the nuclear yeast genes for citrate synthase and fifteen other mitochondrial proteins by a new screening method. EMBO J (1984) 2.33
Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol Cell Biol (1999) 2.32
Distinct NF-kappa B/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature (1993) 2.28
Sequential action of mitochondrial chaperones in protein import into the matrix. EMBO J (1991) 2.27
Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science (1998) 2.27
Heme is necessary for the accumulation and assembly of cytochrome c oxidase subunits in Saccharomyces cerevisiae. J Biol Chem (1978) 2.25
Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70. EMBO J (1990) 2.22
The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J (1996) 2.20
Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. J Exp Med (1995) 2.19
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature (1989) 2.18
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Higher order structure of simian virus 40 chromatin. Science (1978) 2.16
The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting. Cell (1986) 2.14
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Import of proteins into mitochondria. Extramitochondrial pools and post-translational import of mitochondrial protein precursors in vivo. J Biol Chem (1982) 2.12
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Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria. EMBO J (1987) 2.08
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A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria. EMBO J (1984) 1.99
Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins. J Cell Biol (1989) 1.98
Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p. J Cell Biol (1996) 1.98
Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein. EMBO J (1984) 1.97
Import of proteins into mitochondria: nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane. EMBO J (1983) 1.97
MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J (1988) 1.95
DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature (1989) 1.95
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