Published in J Clin Chem Clin Biochem on April 01, 1986
Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts. EMBO J (1989) 1.55
Niemann-Pick type B disease. Identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patients. J Clin Invest (1991) 1.32
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide. J Virol (2000) 1.29
Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest (1999) 1.21
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling. Biochem J (2001) 1.09
Involvement of FAN in TNF-induced apoptosis. J Clin Invest (2001) 1.08
A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase. Protein Sci (2004) 0.91
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity. Proc Natl Acad Sci U S A (2008) 0.89
Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts. Biochem J (1994) 0.86
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis. J Virol (2006) 0.86
Treatment of Niemann-Pick disease type B by allogeneic bone marrow transplantation. Br Med J (Clin Res Ed) (1987) 0.75
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J (1997) 2.56
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol (2007) 1.90
Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. Possible involvement of a platelet lipase. Biochimie (1978) 1.56
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem (1998) 1.52
Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol (1998) 1.49
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J (1996) 1.31
Ceramide in apoptosis signaling: relationship with oxidative stress. Free Radic Biol Med (2001) 1.28
Sphingolipid mediators in cardiovascular cell biology and pathology. Circ Res (2001) 1.26
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia (2006) 1.24
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction. Cancer Res (1992) 1.17
Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. Nature (1981) 1.15
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells. Mol Pharmacol (2001) 1.14
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem (1999) 1.13
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ (2001) 1.12
Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig. Biochim Biophys Acta (1984) 1.11
Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia (2013) 1.10
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling. Biochem J (2001) 1.09
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood (2001) 1.09
Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis. FASEB J (2000) 1.08
Involvement of FAN in TNF-induced apoptosis. J Clin Invest (2001) 1.08
L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation. FASEB J (1999) 1.06
HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs. Cell Death Differ (2010) 1.06
Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators? Biochem Biophys Res Commun (1982) 1.05
Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol. FEBS Lett (1979) 1.04
Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei. Mol Biochem Parasitol (1995) 1.04
Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci U S A (1996) 1.04
Host plasma low density lipoprotein particles as an essential source of lipids for the bloodstream forms of Trypanosoma brucei. J Biol Chem (1995) 1.04
Saposins (sap) A and C activate the degradation of galactosylceramide in living cells. FEBS Lett (1997) 1.03
The turnover of cytoplasmic triacylglycerols in human fibroblasts involves two separate acyl chain length-dependent degradation pathways. J Biol Chem (1995) 1.03
CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway. J Biol Chem (1999) 1.01
Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumor necrosis factor. Eur J Biochem (1996) 1.01
Chlamydia pneumoniae induces interleukin-10 production that down-regulates major histocompatibility complex class I expression. J Infect Dis (2000) 1.01
Uneven X inactivation in a female monozygotic twin pair with Fabry disease and discordant expression of a novel mutation in the alpha-galactosidase A gene. J Med Genet (1996) 1.00
Positive feedback control of neutral sphingomyelinase activity by ceramide. FASEB J (1998) 1.00
Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets. Int J Cancer (2001) 0.99
Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium-dependent pathways in lymphoblastoid cells. FASEB J (1994) 0.99
Activation of epithelial growth factor receptor pathway by unsaturated fatty acids. Circ Res (1999) 0.99
Biochemical characterization of plasma membranes and intracellular membranes isolated from human platelets using Percoll gradients. Biochim Biophys Acta (1986) 0.99
The radiation inactivation method as a tool to study structure-function relationships in proteins. Methods Biochem Anal (1987) 0.98
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines. Biochim Biophys Acta (1990) 0.98
Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. J Biol Chem (2000) 0.98
Platelet activating factor (PAF-acether) promotes an early degradation of phosphatidylinositol-4,5-biphosphate in rabbit platelets. FEBS Lett (1983) 0.97
Isolation and characterization of plasma membranes from krebs II ascite cells using Percoll gradient. Biochim Biophys Acta (1982) 0.97
The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J Biol Chem (1996) 0.97
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue. FEBS Lett (1998) 0.96
Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes. Cardiovasc Res (1999) 0.96
Cytochemical and biochemical studies on neutrophil alkaline phosphatase in parents of trisomy 21 children. Hum Genet (1984) 0.96
Sphingomyelin metabolites in vascular cell signaling and atherogenesis. Prog Lipid Res (2000) 0.96
Bronchoalveolar lavage in liquid paraffin pneumonitis. Chest (1990) 0.95
[CMP-aminoethylphosphonate: intermediary in the phosphonolipids of the rat liver]. Biochimie (1973) 0.95
Activation of EGF receptor by oxidized LDL. FASEB J (1998) 0.95
HDL and ApoA prevent cell death of endothelial cells induced by oxidized LDL. Arterioscler Thromb Vasc Biol (1997) 0.95
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies. Clin Chim Acta (1997) 0.95
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy. Clin Genet (2013) 0.94
Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells. Hum Gene Ther (1999) 0.94
Synthesis of pyrenesulfonylamido-sphingomyelin and its use as substrate for determining sphingomyelinase activity and diagnosing Niemann-Pick disease. Clin Chim Acta (1988) 0.93
HLA class I antibodies provoke graft arteriosclerosis in human arteries transplanted into SCID/beige mice. Am J Transplant (2009) 0.93
Role of protein kinase C δ in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells. Cell Death Dis (2013) 0.92
Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells. Hypertension (2001) 0.92
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan. Mol Pharmacol (2001) 0.92
Preselective gene therapy for Fabry disease. Proc Natl Acad Sci U S A (2001) 0.92
Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia (2006) 0.92
Lysosomal sphingomyelinase is not solicited for apoptosis signaling. FASEB J (2000) 0.92
The distribution of protein kinase C in human leukocytes is altered in microgravity. FASEB J (1996) 0.92
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. FASEB J (1998) 0.91
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins. Biochim Biophys Acta (1990) 0.90
Mitochondrial function is involved in LDL oxidation mediated by human cultured endothelial cells. Arterioscler Thromb Vasc Biol (1997) 0.90
[Alveolar paraffinosis: cytologic and biochemical study of bronchiolo-alveolar lavage fluid]. Rev Mal Respir (1985) 0.90
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D. Cell Death Differ (2003) 0.90
Reactive oxygen species production by mitochondria in endothelial cells exposed to reoxygenation after hypoxia and glucose depletion is mediated by ceramide. Am J Physiol Regul Integr Comp Physiol (2005) 0.89
Broad spectrum anti-platelet activity of ticlopidine and PCR 4099 involves the suppression of the effects of released ADP. Thromb Res (1987) 0.89
Metabolism of 1-pyrenedecanoic acid and accumulation of neutral fluorescent lipids in cultured fibroblasts of multisystemic lipid storage myopathy. Biochim Biophys Acta (1987) 0.89
Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation. Biochim Biophys Acta (1979) 0.89
Fabry's disease: heterozygous form of different expression in two monozygous twin sisters. Dermatology (1993) 0.89
Accurate differentiation of neuronopathic and nonneuronopathic forms of Niemann-Pick disease by evaluation of the effective residual lysosomal sphingomyelinase activity in intact cells. J Neurochem (1994) 0.89
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ (1998) 0.88
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways. Biochim Biophys Acta (1991) 0.88
Protective effect of alpha-tocopherol, ascorbic acid and rutin against peroxidative stress induced by oxidized lipoproteins on lymphoid cell lines. Biochem Pharmacol (1991) 0.88