Published in J Rheumatol on February 01, 1987
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest (2001) 2.90
Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol (1999) 2.08
Minocycline: far beyond an antibiotic. Br J Pharmacol (2013) 1.59
Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. Am J Pathol (2002) 1.41
Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun (1996) 1.24
The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes. Antimicrob Agents Chemother (1996) 1.18
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem (2007) 1.11
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther (2010) 1.03
The influence of tetracyclines on T cell activation. Clin Exp Immunol (1995) 1.03
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrob Agents Chemother (1993) 1.01
Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. Antimicrob Agents Chemother (2000) 0.94
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Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem (2015) 0.90
Therapeutic application of natural inhibitors against snake venom phospholipase A(2). Bioinformation (2012) 0.85
Effects of minocycline-HCl paste root conditioning on periodontal surgery: in vitro and in vivo studies. Int J Clin Exp Med (2015) 0.75
Effect of oxygen-derived free radicals on hyaluronic acid. Arthritis Rheum (1980) 2.20
Myoglobinuria and renal failure associated with typhoid fever. JAMA (1977) 1.91
Effect of sex and age on bone mass, body composition and fuel metabolism in humans. Nutrition (1997) 1.87
Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med (1991) 1.85
Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction. Infect Immun (1992) 1.82
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan. J Clin Invest (1976) 1.77
Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass. Circulation (1999) 1.75
Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. J Periodontal Res (1983) 1.67
Elevated plasma stromelysin levels in arthritis. J Rheumatol (1994) 1.54
Development of clinical criteria for osteoarthritis. J Rheumatol (1987) 1.46
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res (1997) 1.46
Deaths and complications associated with fiberoptic bronchoscopy. Chest (1976) 1.44
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. J Clin Invest (1989) 1.42
Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells. Adv Dent Res (1998) 1.39
Greenwald's law of lupus. J Rheumatol (1992) 1.39
Inferior subluxation of the humeral head: the drooping shoulder. Radiology (1971) 1.39
Colonoscopic evaluation of rectal bleeding: a study of 304 patients. Ann Intern Med (1978) 1.38
Anatomist, scholar and gentleman: Arthur V. Nilsson-a legend in his own time. Chiropr Hist (1984) 1.37
Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol (1995) 1.35
Luxatio erecta in infancy. Clin Orthop Relat Res (1971) 1.32
Unicompartmental tibiofemoral resurfacing arthroplasty. J Bone Joint Surg Am (1978) 1.32
Characterization and functional studies of rheumatoid synovial mast cells. Activation by secretagogues, anti-IgE, and a histamine-releasing lymphokine. Arthritis Rheum (1986) 1.31
A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res (1987) 1.31
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. Oncogene (1997) 1.26
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential. Antimicrob Agents Chemother (1992) 1.23
Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis. Clin Exp Metastasis (1998) 1.22
Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines. J Vasc Surg (1998) 1.21
Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. J Periodontal Res (1990) 1.21
Periodontopathic potential of two strains of Porphyromonas gingivalis in gnotobiotic rats. Arch Oral Biol (1992) 1.18
Inhibition of collagen gelation by action of the superoxide radical. Arthritis Rheum (1979) 1.16
Human cartilage lysozyme. J Clin Invest (1972) 1.14
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis. Arthritis Rheum (1992) 1.13
Double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of respiratory distress syndrome. Pediatrics (1985) 1.12
Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontol (1996) 1.12
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. J Rheumatol (1992) 1.10
Modulation of bone resorption by tetracyclines. Ann N Y Acad Sci (1994) 1.10
Degradation of hyaluronic acid by polymorphonuclear leukocytes. Inflammation (1986) 1.10
Periodontal bone level and gingival proteinase activity in gnotobiotic rats immunized with Bacteroides gingivalis. Oral Microbiol Immunol (1991) 1.09
Local gangrene: a complication of peripheral Pitressin therapy for bleeding esophageal varices. Gastroenterology (1978) 1.09
Adjunctive treatment with subantimicrobial doses of doxycycline: effects on gingival fluid collagenase activity and attachment loss in adult periodontitis. J Clin Periodontol (2001) 1.09
Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J Periodontol (1993) 1.09
Modular total knee-replacement arthroplasty. A review of eighty-nine patients. J Bone Joint Surg Am (1976) 1.08
Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR. Int J Cancer (1995) 1.08
Systemic tetracycline treatment of alkali-induced corneal ulceration in rabbits. Arch Ophthalmol (1987) 1.07
Neglected aspects of informed consent. N Engl J Med (1977) 1.07
Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease. J Periodontal Res (1984) 1.07
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats. Ann N Y Acad Sci (1999) 1.06
Urea content of gingival crevicular fluid and its relation to periodontal diseases in humans. J Periodontal Res (1971) 1.06
Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: a multicenter, placebo-controlled, double-blind study. Arthritis Rheum (1998) 1.05
Randomized trial of epidural versus general anesthesia: outcomes after primary total knee replacement. Clin Orthop Relat Res (1996) 1.05
Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives. J Periodontol (2002) 1.05
Gingival crevicular fluid: a new diagnostic aid in managing the periodontal patient. Oral Sci Rev (1976) 1.03
Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience (1992) 1.03
The "cyclic" regimen of low-dose doxycycline for adult periodontitis: a preliminary study. J Periodontol (1996) 1.02
Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes. Ann N Y Acad Sci (1994) 1.02
Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol (1996) 1.02
Some characteristics of collagenase activity in gingival crevicular fluid and its relationship to gingival diseases in humans. J Dent Res (1977) 1.02
Percutaneous transhepatic cholangiography with the "skinny" needle. A rapid, simple, and accurate method in the diagnosis of cholestasis. Ann Intern Med (1977) 1.01
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article. J Periodontol (1993) 1.01
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrob Agents Chemother (1993) 1.01
Intertrochanteric fractures of the hip in the elderly: a retrospective analysis of 236 cases. Clin Orthop Relat Res (1979) 1.00
Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat Res (1994) 1.00
Rotating hinge total knee arthroplasty in severly affected knees. Clin Orthop Relat Res (2000) 1.00
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase. J Bone Miner Res (1993) 0.99
Total knee arthroplasty after a previous patellectomy. J Bone Joint Surg Am (1995) 0.99
Seropositive rheumatoid arthritis in a patient with cystic fibrosis. Am J Dis Child (1980) 0.98
Synthesis, secretion, and deposition of fibronectin in cultured human synovium. Arthritis Rheum (1985) 0.98
Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline. Biochem Pharmacol (1992) 0.98
Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity. Curr Med Chem (2001) 0.98
MMP-mediated events in diabetes. Ann N Y Acad Sci (1999) 0.98
Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: a quantitative autoradiographic study. Calcif Tissue Int (1992) 0.97
Novel evolutionary pathways of sex-determining mechanisms. J Evol Biol (2013) 0.97
The role of microorganisms in the production of oral malodor. Oral Surg Oral Med Oral Pathol (1972) 0.97