Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.

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Published in J Clin Invest on January 01, 2001

Authors

L A Neuhold1, L Killar, W Zhao, M L Sung, L Warner, J Kulik, J Turner, W Wu, C Billinghurst, T Meijers, A R Poole, P Babij, L J DeGennaro

Author Affiliations

1: Molecular Genetics Division, Wyeth-Ayerst Research, Princeton, New Jersey, USA. neuholl@genetics.com

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Risk of locoregional recurrence by receptor status in breast cancer patients receiving modern systemic therapy and post-mastectomy radiation. Breast Cancer Res Treat (2011) 1.77

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest (1995) 1.77

Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis. Infect Immun (2001) 1.77

A molecular switch in a replication machine defined by an internal competition for protein rings. Cell (1996) 1.77

Proteoglycans in health and disease: structures and functions. Biochem J (1986) 1.75

Medical complications in long-term survivors with X-linked myotubular myopathy. J Pediatr (1999) 1.74

Alpha-2 macroglobulin gene and Alzheimer disease. Nat Genet (1999) 1.73

Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest (1990) 1.71

"Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency. J Clin Endocrinol Metab (1999) 1.70

Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies. J Biol Chem (1997) 1.70

Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. Mol Cell (2000) 1.70

Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. Stroke (1998) 1.69

Replisome assembly reveals the basis for asymmetric function in leading and lagging strand replication. Cell (1996) 1.68

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Response rates, duration of response, and dose response effects in phase I studies of antineoplastics. Invest New Drugs (1991) 1.67