Published in J Neurosci on August 01, 1987
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A (1997) 3.26
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci U S A (1992) 2.84
Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. J Neurosci (2007) 2.51
Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46
The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev (2009) 2.35
Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron (2014) 2.33
The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology (Berl) (2012) 1.96
The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse. Neuroscience (2007) 1.82
The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors. Biol Psychiatry (2013) 1.69
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron (1995) 1.56
Role of kappa-opioid receptors in stress and anxiety-related behavior. Psychopharmacology (Berl) (2013) 1.53
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci U S A (1993) 1.47
Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biol Psychiatry (2006) 1.43
Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proc Natl Acad Sci U S A (2007) 1.42
Hyperpolarization by opioids acting on mu-receptors of a sub-population of rat periaqueductal gray neurones in vitro. Br J Pharmacol (1994) 1.41
mu opiate receptor: cDNA cloning and expression. Proc Natl Acad Sci U S A (1993) 1.39
Intracranial self-stimulation to evaluate abuse potential of drugs. Pharmacol Rev (2014) 1.37
kappa-Opioid receptor signaling and brain reward function. Brain Res Rev (2009) 1.32
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology (2011) 1.29
The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proc Natl Acad Sci U S A (1995) 1.25
Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation. Br J Pharmacol (2000) 1.24
Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. J Neurosci (2008) 1.18
Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it? Prog Neurobiol (2009) 1.18
Single potassium channels opened by opioids in rat locus ceruleus neurons. Proc Natl Acad Sci U S A (1989) 1.18
Activation of μ-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles. Neuropsychopharmacology (2011) 1.13
Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. Alcohol (2012) 1.12
Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex. J Neurosci (2011) 1.12
Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior. Neuropsychopharmacology (2009) 1.08
Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br J Pharmacol (2010) 1.07
Endocannabinoid system involvement in brain reward processes related to drug abuse. Pharmacol Res (2007) 1.07
Looking for the role of cannabinoid receptor heteromers in striatal function. Neuropharmacology (2008) 1.06
kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression. Proc Natl Acad Sci U S A (1996) 1.05
Transcriptome signature of the adult mouse choroid plexus. Fluids Barriers CNS (2011) 1.05
Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology (2006) 1.03
Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms. Eur J Neurosci (2009) 1.02
A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct (2014) 1.00
Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. J Nucl Med (2013) 0.98
A neuropeptide-centric view of psychostimulant addiction. Br J Pharmacol (2008) 0.97
Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. J Neurosci (2013) 0.97
Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brain. Brain Res (2004) 0.96
Naloxone attenuates incubated sucrose craving in rats. Psychopharmacology (Berl) (2007) 0.95
Alterations in endogenous opioid functional measures in chronic back pain. J Neurosci (2013) 0.94
Microinjection of the delta-opioid receptor selective antagonist naltrindole 5'-isothiocyanate site specifically affects cocaine self-administration in rats responding under a progressive ratio schedule of reinforcement. Behav Brain Res (2007) 0.93
The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different? Neural Plast (2009) 0.93
Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. Pharmacol Biochem Behav (2006) 0.92
Mu-opioid and corticotropin-releasing-factor receptors show largely postsynaptic co-expression, and separate presynaptic distributions, in the mouse central amygdala and bed nucleus of the stria terminalis. Neuroscience (2009) 0.92
Does the kappa opioid receptor system contribute to pain aversion? Front Pharmacol (2014) 0.92
A role for mu opioid receptors in cocaine-induced activity, sensitization, and reward in the rat. Psychopharmacology (Berl) (2007) 0.91
Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry (2007) 0.91
Functional magnetic resonance imaging studies of opioid receptor-mediated modulation of noxious-evoked BOLD contrast in rats. Psychopharmacology (Berl) (2005) 0.90
Opioids in the nucleus accumbens stimulate ethanol intake. Physiol Behav (2009) 0.90
Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biol Psychiatry (2013) 0.90
Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (1994) 0.90
Effects of opioids, cannabinoids, and vanilloids on body temperature. Front Biosci (Schol Ed) (2011) 0.90
Neuroanatomical distribution of μ-opioid receptor mRNA and binding in monogamous prairie voles (Microtus ochrogaster) and non-monogamous meadow voles (Microtus pennsylvanicus). Neuroscience (2013) 0.89
The role of amygdalar mu-opioid receptors in anxiety-related responses in two rat models. Neuropsychopharmacology (2008) 0.89
Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol (2012) 0.88
GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4. J Neuroimmune Pharmacol (2007) 0.88
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci (2010) 0.88
Epileptiform synchronization in the cingulate cortex. Epilepsia (2008) 0.88
Opioid receptors in the basolateral amygdala but not dorsal hippocampus mediate context-induced alcohol seeking. Behav Brain Res (2010) 0.86
The anterior cingulate cortex and pain processing. Front Integr Neurosci (2014) 0.86
Influence of intramuscular heat stimulation on modulation of nociception: complex role of central opioid receptors in descending facilitation and inhibition. J Physiol (2014) 0.86
The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats. Brain Behav (2014) 0.86
Opioid modulation of Fos protein expression and olfactory circuitry plays a pivotal role in what neonates remember. Learn Mem (2006) 0.86
Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity. Psychopharmacology (Berl) (2014) 0.85
Rapid, transient, and dose-dependent expression of hsp70 messenger RNA in the rat brain after morphine treatment. Cell Stress Chaperones (2004) 0.85
Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. Curr Psychiatry Rev (2014) 0.85
Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain. Brain Res (2013) 0.85
Influence of δ-opioid receptors in the behavioral effects of nicotine. Neuropsychopharmacology (2012) 0.85
Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. Eur J Pharmacol (2006) 0.84
Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl) (2013) 0.84
The neuroanatomy of sexual dimorphism in opioid analgesia. Exp Neurol (2014) 0.84
Modulation of feeding and locomotion through mu and delta opioid receptor signaling in the nucleus accumbens. Neuropeptides (2009) 0.84
HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. Front Microbiol (2015) 0.83
Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains. PLoS One (2014) 0.82
Hypothalamic neuropeptide signaling in alcohol addiction. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.82
MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys. Int J Med Chem (2012) 0.82
Dissociating Motivational From Physiological Withdrawal in Alcohol Dependence: Role of Central Amygdala κ-Opioid Receptors. Neuropsychopharmacology (2015) 0.82
Orphanin FQ suppresses NMDA receptor-dependent long-term depression and depotentiation in hippocampal dentate gyrus. Learn Mem (1999) 0.82
Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role. Front Cell Neurosci (2013) 0.81
Layer selective presynaptic modulation of excitatory inputs to hippocampal cornu Ammon 1 by mu-opioid receptor activation. Neuroscience (2007) 0.81
Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats. Neuropsychopharmacology (2013) 0.80
Anterior Cingulate epilepsy: mechanisms and modulation. Front Integr Neurosci (2014) 0.80
Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter. Int J Mol Sci (2009) 0.80
Functional interaction between medial thalamus and rostral anterior cingulate cortex in the suppression of pain affect. Neuroscience (2010) 0.80
Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos. Brain Res (2009) 0.80
Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus. Am J Physiol Regul Integr Comp Physiol (2008) 0.80
Opioid administration following spinal cord injury: implications for pain and locomotor recovery. Exp Neurol (2013) 0.79
Buprenorphine differentially alters opioid receptor adaptation in rat brain regions. J Pharmacol Exp Ther (1996) 0.79
The role of the dynorphin/κ opioid receptor system in anxiety. Acta Pharmacol Sin (2015) 0.79
Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain. J Biomed Sci (2011) 0.79
Context-dependent links between song production and opioid-mediated analgesia in male European starlings (Sturnus vulgaris). PLoS One (2012) 0.79
Activation of delta-opioid receptors reduces excitatory input to putative gustatory cells within the nucleus of the solitary tract. J Neurophysiol (2008) 0.79
μ and κ opioid receptor distribution in the monogamous titi monkey (Callicebus cupreus): implications for social behavior and endocrine functioning. Neuroscience (2015) 0.78
Mu opioid receptor localization in the basolateral amygdala: An ultrastructural analysis. Neuroscience (2015) 0.78
Effects of μ-opioid receptor modulation on the hippocampal network activity of sharp wave and ripples. Br J Pharmacol (2013) 0.78
Bilateral lesions of the thalamic trigeminal orosensory area dissociate natural from drug reward in contrast paradigms. Behav Neurosci (2012) 0.78
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons. Drug Alcohol Depend (2011) 0.78
A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. Nat Genet (2000) 3.71
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci (1995) 3.00
Anatomy of CNS opioid receptors. Trends Neurosci (1988) 2.82
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem (1993) 2.81
Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience (1995) 2.69
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science (1991) 2.63
Endogenous opioids: biology and function. Annu Rev Neurosci (1984) 2.54
Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules. J Neurosci (2000) 2.42
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A (2005) 2.38
Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science (1976) 2.35
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol (1994) 2.33
Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U S A (1998) 2.22
Dysregulation of the fibroblast growth factor system in major depression. Proc Natl Acad Sci U S A (2004) 2.19
High-resolution in situ hybridization histochemistry. Methods Enzymol (1989) 2.11
Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07
Incorporation of endovascular training into a vascular fellowship program. Am J Surg (1995) 2.05
Prognosis of depression in elderly community and primary care populations: a systematic review and meta-analysis. Am J Psychiatry (1999) 1.94
Molecular cloning of a novel melanocortin receptor. J Biol Chem (1993) 1.89
Ventral subicular interaction with the hypothalamic paraventricular nucleus: evidence for a relay in the bed nucleus of the stria terminalis. J Comp Neurol (1993) 1.83
Analgesia from electrical stimulation in the brainstem of the rat. Science (1971) 1.81
Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J Neurosci (1999) 1.80
A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol Psychiatry (1998) 1.80
Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol (1999) 1.77
Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1beta. J Comp Neurol (1999) 1.76
Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry (1991) 1.75
Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron (1993) 1.68
Social stress in hamsters: defeat activates specific neurocircuits within the brain. J Neurosci (1997) 1.60
Infections, vaccinations, and the risk of childhood leukaemia. Br J Cancer (1999) 1.59
Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS. J Chem Neuroanat (1995) 1.56
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J Neurosci (1990) 1.56
Opioid effects on mitogen-activated protein kinase signaling cascades. Anesthesiology (1997) 1.55
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding. J Comp Neurol (1999) 1.52
Differential expression of protein phosphatase 1 isoforms in mammalian brain. J Neurosci (1995) 1.50
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J Neurosci (1989) 1.50
A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet (2001) 1.49
Differential binding properties of oripavines at cloned mu- and delta-opioid receptors. Eur J Pharmacol (1999) 1.48
Neuroendocrine and behavioral responses and brain pattern of c-fos induction associated with audiogenic stress. J Neuroendocrinol (1997) 1.48
Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry (1998) 1.48
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci U S A (1993) 1.47
Early progressive encephalopathy in boys and MECP2 mutations. Neurology (2006) 1.44
Familial Mediterranean fever in six Australian children. Med J Aust (1989) 1.43
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry (2010) 1.42
A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience (2011) 1.41
Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor. J Pharmacol Exp Ther (1996) 1.39
Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders. Mol Psychiatry (2006) 1.38
Common peroneal nerve injury during varicose vein operation. Eur J Vasc Endovasc Surg (2005) 1.38
Extrapulmonary tuberculosis in children. Med J Aust (1993) 1.38
Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat. Mol Endocrinol (1989) 1.38
Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat (1997) 1.37
Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm Behav (2000) 1.34
Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Mol Endocrinol (1992) 1.34
mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding. Brain Res (1994) 1.34
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop. Eur J Pharmacol (2000) 1.32
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior. Psychopharmacology (Berl) (2001) 1.32
Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty. J Neurosci (1998) 1.31
Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat. J Neuroendocrinol (1999) 1.31
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons. Behav Brain Res (1999) 1.31
Pain reduction by electrical brain stimulation in man. Part 2: Chronic self-administration in the periventricular gray matter. J Neurosurg (1977) 1.30
Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA. Brain Res Mol Brain Res (1995) 1.29
Nonopiate effects of dynorphin and des-Tyr-dynorphin. Science (1982) 1.29