Published in Neurosci Biobehav Rev on January 01, 1988
From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 15.90
Disease tolerance as a defense strategy. Science (2012) 5.22
Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun (2006) 4.55
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest (2004) 3.70
Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol (2011) 2.87
Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. Cell (2017) 2.67
From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull (2014) 2.39
The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol (2009) 2.27
Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron (2010) 2.24
Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther (2011) 2.12
Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs. Philos Trans R Soc Lond B Biol Sci (2008) 1.99
Symptom clusters in cancer patients. Support Care Cancer (2006) 1.99
Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol Psychiatry (2010) 1.95
Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci (2009) 1.89
Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc Natl Acad Sci U S A (2010) 1.87
Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav Immun (2010) 1.85
Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol Psychiatry (2008) 1.85
An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage (2009) 1.79
The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1. Brain Behav Immun (2009) 1.76
Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res (2008) 1.72
Dr William Coley and tumour regression: a place in history or in the future. Postgrad Med J (2003) 1.72
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci (2012) 1.67
Cytokine, sickness behavior, and depression. Neurol Clin (2006) 1.58
Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am (2009) 1.56
Implications of immune-to-brain communication for sickness and pain. Proc Natl Acad Sci U S A (1999) 1.52
Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc Natl Acad Sci U S A (1992) 1.49
Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology (2011) 1.48
Nicotine administration and withdrawal affect survival in systemic inflammation models. J Appl Physiol (1985) (2008) 1.48
Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res (2006) 1.48
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry (2012) 1.41
Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. Nat Neurosci (2017) 1.40
Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol (2010) 1.38
Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med (2012) 1.37
The immune system and developmental programming of brain and behavior. Front Neuroendocrinol (2012) 1.36
Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav Immun (2008) 1.28
Neural substrate of cold-seeking behavior in endotoxin shock. PLoS One (2006) 1.24
Behavioural defences in animals against pathogens and parasites: parallels with the pillars of medicine in humans. Philos Trans R Soc Lond B Biol Sci (2011) 1.23
The primary headaches: genetics, epigenetics and a behavioural genetic model. J Headache Pain (2008) 1.21
Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage (2011) 1.19
The relationship of cancer symptom clusters to depressive affect in the initial phase of palliative radiation. J Pain Symptom Manage (2005) 1.19
Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory. Brain Behav Immun (2008) 1.18
Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain Behav Immun (2007) 1.17
Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits. J Physiol (2007) 1.15
Short day lengths attenuate the symptoms of infection in Siberian hamsters. Proc Biol Sci (2002) 1.15
Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediators Inflamm (2013) 1.14
Microglia activation in sepsis: a case-control study. J Neuroinflammation (2007) 1.13
Effects of interleukin-1beta and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests. Pharmacol Biochem Behav (2007) 1.13
Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology (2008) 1.13
Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp Neurol (2010) 1.12
Parasite resistance and the adaptive significance of sleep. BMC Evol Biol (2009) 1.12
At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. Brain Behav Immun (2012) 1.11
Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. J Clin Invest (1994) 1.11
Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders. Brain Behav Immun (2010) 1.11
Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli. J Neurosci (2009) 1.10
Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging Dis (2010) 1.09
Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey. Brain Behav Immun (2007) 1.08
MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. J Neuroinflammation (2008) 1.07
Stress responses: the contribution of prostaglandin E(2) and its receptors. Nat Rev Endocrinol (2010) 1.07
Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes. Transl Psychiatry (2012) 1.06
The neuroimmune basis of fatigue. Trends Neurosci (2013) 1.05
Pathophysiology of cancer-related fatigue. Clin J Oncol Nurs (2008) 1.05
Hypothalamic mechanisms in cachexia. Physiol Behav (2010) 1.04
Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav Immun (2009) 1.04
Anti-inflammatory agents attenuate the passive responses of guinea pig pups: evidence for stress-induced sickness behavior during maternal separation. Psychoneuroendocrinology (2007) 1.04
Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One (2012) 1.03
Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. Brain Behav Immun (2008) 1.03
Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Eur J Neurosci (2008) 1.02
Central and peripheral neuroimmune responses: hyporesponsiveness during pregnancy. J Physiol (2007) 1.02
Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res (2006) 1.02
Anti-inflammatory influences on behavioral, but not cortisol, responses during maternal separation. Psychoneuroendocrinology (2009) 1.01
Immune challenge retards seasonal reproductive regression in rodents: evidence for terminal investment. Biol Lett (2006) 0.98
Sickness behaviour acting as an evolutionary trap? Male house finches preferentially feed near diseased conspecifics. Biol Lett (2010) 0.98
Early attachment-figure separation and increased risk for later depression: potential mediation by proinflammatory processes. Neurosci Biobehav Rev (2009) 0.97
NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem (2010) 0.96
Microglia in the cerebral cortex in autism. J Autism Dev Disord (2012) 0.95
Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain. J Neuroimmune Pharmacol (2012) 0.95
Immune and behavioral consequences of microglial reactivity in the aged brain. Integr Comp Biol (2009) 0.95
Neurobiological alterations induced by exercise and their impact on depressive disorders [corrected]. Clin Pract Epidemiol Ment Health (2010) 0.94
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology (2008) 0.94
Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus. BMC Infect Dis (2006) 0.94
Infection-induced proinflammatory cytokines are associated with decreases in positive affect, but not increases in negative affect. Brain Behav Immun (2006) 0.94
Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides. PLoS One (2013) 0.94
Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms. Dialogues Clin Neurosci (2014) 0.93
Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge. Brain Behav Immun (2008) 0.92
Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Proc Natl Acad Sci U S A (2005) 0.92
Sex-specific social regulation of inflammatory responses and sickness behaviors. Brain Behav Immun (2010) 0.92
Winter day lengths enhance T lymphocyte phenotypes, inhibit cytokine responses, and attenuate behavioral symptoms of infection in laboratory rats. Brain Behav Immun (2007) 0.92
Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus. J Neuroinflammation (2009) 0.92
Toxins induce 'malaise' behaviour in the honeybee (Apis mellifera). J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2014) 0.91
Reduction in pain response by combined use of local lidocaine anesthesia and systemic ketoprofen in dairy calves dehorned by heat cauterization. Can Vet J (2010) 0.91
Selection for increased mass-independent maximal metabolic rate suppresses innate but not adaptive immune function. Proc Biol Sci (2013) 0.91
Interoceptive dysfunction: toward an integrated framework for understanding somatic and affective disturbance in depression. Psychol Bull (2014) 0.90
Advances in deoxynivalenol toxicity mechanisms: the brain as a target. Toxins (Basel) (2012) 0.90
Inflammation-sleep interface in brain disease: TNF, insulin, orexin. J Neuroinflammation (2014) 0.90
Behavioral and endocrine effects of endotoxin in wild-type mice and mice deficient in interleukin 1: sickness behavior or adaptive response? Dokl Biol Sci (2003) 0.89
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets. Curr Neuropharmacol (2016) 0.89
Lipopolysaccharide suppresses activation of the tuberomammillary histaminergic system concomitant with behavior: a novel target of immune-sensory pathways. Neuroscience (2008) 0.89
Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection. Brain Behav Immun (2012) 0.89
Systemic inflammation decreases pain threshold in humans in vivo. PLoS One (2013) 0.89
Maternal and developmental immune challenges alter behavior and learning ability of offspring. Horm Behav (2012) 0.88
Behavioral adaptations to pathogens and parasites: five strategies. Neurosci Biobehav Rev (1990) 2.82
Behavioral adaptations to parasites: an ethological approach. J Parasitol (1992) 1.21
Postcopulatory genital grooming in male rats: prevention of sexually transmitted infections. Physiol Behav (1987) 1.11
Antibacterial properties of saliva: role in maternal periparturient grooming and in licking wounds. Physiol Behav (1990) 0.83
Advances in obsessive-compulsive disorder. Neuropsychopharmacology (1991) 0.75