From inflammation to sickness and depression: when the immune system subjugates the brain.

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Published in Nat Rev Neurosci on January 01, 2008

Authors

Robert Dantzer1, Jason C O'Connor, Gregory G Freund, Rodney W Johnson, Keith W Kelley

Author Affiliations

1: Integrative Immunology & Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois 61801, USA. dantzer@uiuc.edu

Associated clinical trials:

Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial | NCT02263872

Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers | NCT02628054

Influenza Challenge in Mood Disorders | NCT02415166

Preeclampsia Research on Vitamin D, Inflammation, & Depression (PROVIDE) | NCT03018132

Rapid Antidepressant Effects of Leucine | NCT03079297

Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes | NCT03580967

A Longitudinal Study of Inflammatory Pathways in Depression | NCT04159207

Relationships Among Inflammation, Physical and Mental Health in Subjects With Chronic Inflammatory Physical Diseases. (InflaMent) | NCT05125458

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Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci (2010) 1.06

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav Immun (2007) 1.04

Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Eur J Neurosci (2008) 1.02

Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obesity (Silver Spring) (2011) 1.01

Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK. J Immunol (2007) 1.01

Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide. Brain Behav Immun (2009) 1.01

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts. J Neuroimmunol (2007) 1.01

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior. J Neuroinflammation (2011) 1.01

Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology (2002) 1.00

Detection of Chlamydia trachomatis and Neisseria gonorrhoeae infections in North American women by testing SurePath liquid-based Pap specimens in APTIMA assays. J Clin Microbiol (2007) 1.00

Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr (2010) 0.99

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus. J Biol Chem (2004) 0.98

alpha-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice. J Nutr (2005) 0.98

Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor. Cancer Res (2002) 0.98

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors. J Neuroinflammation (2013) 0.98

Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization. Brain Behav Immun (2010) 0.97

The implication of proinflammatory cytokines in type 2 diabetes. Front Biosci (2008) 0.97

C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. Endocrinology (2006) 0.96

Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice. J Neuroinflammation (2011) 0.96

LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia. Brain Behav Immun (2009) 0.95

A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats. J Nutr (2006) 0.95

Place and direction learning in a spatial T-maze task by neonatal piglets. Anim Cogn (2012) 0.95

Mouse testing methods in psychoneuroimmunology: an overview of how to measure sickness, depressive/anxietal, cognitive, and physical activity behaviors. Methods Mol Biol (2012) 0.95

The biobehavioral and neuroimmune impact of low-dose ionizing radiation. Brain Behav Immun (2011) 0.95

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. Pain (2011) 0.94

Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta. J Biol Chem (2001) 0.94

Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice. Psychoneuroendocrinology (2013) 0.94

Voluntary wheel running reverses age-induced changes in hippocampal gene expression. PLoS One (2011) 0.94