Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase.

Super-resolution biomolecular crystallography with low-resolution data. Nature (2010) 6.14

On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25

Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction. Proc Natl Acad Sci U S A (1998) 2.62

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J (1993) 2.54

Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Proc Natl Acad Sci U S A (1997) 2.23

The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J (1994) 1.99

Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase. Proc Natl Acad Sci U S A (1993) 1.70

Crystal structure of prokaryotic ribosomal protein L9: a bi-lobed RNA-binding protein. EMBO J (1994) 1.52

2.9 A crystal structure of ligand-free tryptophanyl-tRNA synthetase: domain movements fragment the adenine nucleotide binding site. Protein Sci (2000) 1.40

The three-dimensional structure of canavalin from jack bean (Canavalia ensiformis). Plant Physiol (1993) 1.39

Studies of the ligand binding reaction of adipocyte lipid binding protein using the fluorescent probe 1, 8-anilinonaphthalene-8-sulfonate. Biophys J (1999) 1.37

Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities. Proc Natl Acad Sci U S A (1994) 1.36

The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif. EMBO J (1998) 1.30

RPBS: a web resource for structural bioinformatics. Nucleic Acids Res (2005) 1.28

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14

Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Sci (1999) 1.12

The tree-dimensional structure of aspergillus niger pectin lyase B at 1.7-A resolution. Plant Physiol (1998) 1.08

Crystal structure of brain-type creatine kinase at 1.41 A resolution. Protein Sci (1999) 1.06

YUP.SCX: coaxing atomic models into medium resolution electron density maps. J Struct Biol (2008) 1.06

Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proc Natl Acad Sci U S A (1991) 0.97

Polarizable atomic multipole X-ray refinement: application to peptide crystals. Acta Crystallogr D Biol Crystallogr (2009) 0.97

Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases. J Biol Chem (2006) 0.94

Crystal structure to 2.45 A resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen. Protein Sci (1993) 0.93

Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops. J Bacteriol (2003) 0.91

Reconstruction of protein conformations from estimated positions of the C alpha coordinates. Protein Sci (1993) 0.89

Mutations of endo-beta-N-acetylglucosaminidase H active site residueAs sp130 anG glu132: activities and conformations. Protein Sci (1999) 0.87

A structural snapshot of base-pair opening in DNA. Proc Natl Acad Sci U S A (1999) 0.86

Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain. Proc Natl Acad Sci U S A (1992) 0.85

Crystal structure of thymidylate synthase A from Bacillus subtilis. Protein Sci (1999) 0.85

Crystal structure of the coat protein from the GA bacteriophage: model of the unassembled dimer. Protein Sci (1996) 0.82

X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin. Biochemistry (2010) 0.82

Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein Sci (1997) 0.80

Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the "glass transition" in protein dynamics. Bioorg Chem (2006) 0.78

A high quality nuclear magnetic resonance solution structure of peptide deformylase from Escherichia coli: application of an automated assignment strategy using GARANT. J Biomol NMR (1999) 0.78

CHRAMM-GUI MDFF/xMDFF Utilizer for Molecular Dynamics Flexible Fitting Simulations in Various Environments. J Phys Chem B (2016) 0.75

Assessing the quality of solution nuclear magnetic resonance structures by complete cross-validation. Science (1993) 1.40

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain. Proc Natl Acad Sci U S A (1990) 1.16

Computational challenges for macromolecular structure determination by X-ray crystallography and solution NMR-spectroscopy. Q Rev Biophys (1993) 1.16

Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement. Acta Crystallogr A (1991) 0.94

2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. J Mol Biol (1991) 0.94