Published in Am J Hum Genet on March 01, 1986
Bias of the contribution of single-locus effects to the variance of a quantitative trait. Am J Hum Genet (1986) 1.65
Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension. Am J Hum Genet (1991) 1.45
Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. J Clin Invest (1994) 1.42
Genetic determination of plasma apolipoprotein AI in a population-based sample. Am J Hum Genet (1989) 1.29
Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am J Hum Genet (2002) 1.22
Genetic analysis of apolipoprotein A-I in two dietary environments. Am J Hum Genet (1990) 1.15
Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance. Am J Hum Genet (1988) 1.13
Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples. BMC Genet (2003) 0.89
Genetic determination of high-density lipoprotein-cholesterol and apolipoprotein A-1 plasma levels in a family study of cardiac catheterization patients. Am J Hum Genet (1992) 0.89
Pedigree analysis of HDL cholesterol concentration in baboons on two diets. Am J Hum Genet (1988) 0.83
A general model for the genetic analysis of pedigree data. Hum Hered (1971) 40.17
Analysis of family resemblance. 3. Complex segregation of quantitative traits. Am J Hum Genet (1974) 9.68
A unified model for complex segregation analysis. Am J Hum Genet (1983) 5.67
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet (1985) 3.81
Localization of the structural gene for human apolipoprotein A-I on the long arm of human chromosome 11. Proc Natl Acad Sci U S A (1984) 3.70
Isolation and characterization of the human apolipoprotein A-I gene. Proc Natl Acad Sci U S A (1983) 2.42
A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest (1980) 2.27
A mixed-model likelihood approximation on large pedigrees. Comput Biomed Res (1982) 2.10
An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis. Nature (1983) 1.80
The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins. Biochem Biophys Res Commun (1978) 1.75
The measurement of apolipoprotein A-I and A-II levels in men and women by immunoassay. J Clin Invest (1977) 1.75
Apoproteins B and A-I and coronary artery disease in humans. Arteriosclerosis (1984) 1.73
Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease. N Engl J Med (1982) 1.67
Linkage of human apolipoproteins A-I and C-III genes. Nature (1983) 1.66
Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci U S A (1982) 1.66
Improved method for determination of high-density-lipoprotein cholesterol I. Isolation of high-density lipoproteins by use of polyethylene glycol 6000. Clin Chem (1981) 1.58
Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N Engl J Med (1983) 1.56
Quantitation of apolipoprotein A-I of human plasma high density lipoprotein. Metabolism (1976) 1.55
Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry (1981) 1.51
Assay of total plasma apolipoprotein B concentration in human subjects. J Clin Invest (1974) 1.46
Isolation of the human HDL apoprotein A1 gene. Nucleic Acids Res (1982) 1.36
Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. J Biol Chem (1983) 1.23
Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency. Arteriosclerosis (1984) 1.22
Human apolipoprotein A-I--C-III gene complex is located on chromosome 11. Arteriosclerosis (1984) 1.14
The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II. Atherosclerosis (1984) 1.03
Genetic analysis of sodium-lithium countertransport in 10 hypertension-prone kindreds. Am J Med Genet (1984) 1.02
Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits. Am J Hum Genet (1984) 1.01
One-step screening method for the polymorphism of apolipoproteins A-I, A-II, and A-IV. J Lipid Res (1982) 1.00
Primary and familial hypoalphalipoproteinemia. Metabolism (1984) 0.99
Apolipoprotein AIMarburg: studies on two kindreds with a mutant of human apolipoprotein AI. Hum Genet (1982) 0.96
Detection of genetic heterogeneity among pedigrees through complex segregation analysis: an application to hypercholesterolemia. Am J Hum Genet (1984) 0.94
A revised estimate of the amount of genetic variation in human proteins: implications for the distribution of DNA polymorphisms. Am J Hum Genet (1984) 0.94
Serum apolipoprotein A-I, A-II and B levels and their discriminative values in relatives of patients with coronary artery disease. Atherosclerosis (1984) 0.94
Tangier disease: a structural defect in apolipoprotein A-I (apoA-I Tangier). Proc Natl Acad Sci U S A (1982) 0.91
On the heritability of serum high density lipoprotein in twins. Am J Hum Genet (1980) 0.90
Radioimmunoassay of apolipoprotein A-i. application of a non-ionic detergent (Tween-20) and solid-phase staphylococcus. Clin Chem (1982) 0.87
Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type. J Biol Chem (1984) 0.86
Alterations of plasma high-density lipoprotein cholesterol levels associated with consumption of selected medications. The Lipid Research Clinics Program Prevalence Study. Circulation (1980) 0.78
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet (1998) 11.70
A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimation. Genetics (1992) 10.09
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet (1998) 7.56
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. Genome Res (2001) 6.06
Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis (1988) 6.01
The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet (1986) 5.02
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation (1996) 4.62
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet (1985) 3.81
Disparities in incidence of diabetic end-stage renal disease according to race and type of diabetes. N Engl J Med (1989) 3.67
The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med (1992) 3.53
Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. J Natl Cancer Inst (1977) 3.39
Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics (1988) 3.20
Recombinational and mutational hotspots within the human lipoprotein lipase gene. Am J Hum Genet (2000) 2.83
The unit of selection in Drosophila mercatorum. I. The interation of selection and meiosis in parthenogenetic strains. Genetics (1976) 2.71
A cladistic analysis of phenotype associations with haplotypes inferred from restriction endonuclease mapping. II. The analysis of natural populations. Genetics (1988) 2.68
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet (2000) 2.62
The population genetics of parthenogenetic strains of Drosophila mercatorium. II The capacity for parthenogenesis in a natural, bisexual population. Genetics (1976) 2.56
Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Genome Res (2000) 2.53
A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. IV. Nested analyses with cladogram uncertainty and recombination. Genetics (1993) 2.52
Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob Agents Chemother (1997) 2.44
Cancer incidence by levels of cholesterol. JAMA (1981) 2.42
Breast and thyroid cancer and malignant melanoma promoted by alcohol-induced pituitary secretion of prolactin, T.S.H. and M.S.H. Lancet (1976) 2.34
Analysis of multilocus genetic systems in Tecumseh, Michigan. II. Consideration of the correlation between nonalleles in gametes. Am J Hum Genet (1972) 2.32
A comparison of positive family history definitions for defining risk of future disease. J Chronic Dis (1986) 2.30
A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia. Antimicrob Agents Chemother (1997) 2.19
Utah pedigree studies: design and preliminary data for premature male CHD deaths. Prog Clin Biol Res (1979) 2.11
Serum lipids and lipoproteins are less powerful predictors of extracranial carotid artery atherosclerosis than are cigarette smoking and hypertension. Mayo Clin Proc (1991) 2.02
Associations of cancer site and type with occupation and industry from the Third National Cancer Survey Interview. J Natl Cancer Inst (1977) 2.02
A model for analysis of population structure. Genetics (1974) 2.02
Familial dependence of the resting metabolic rate. N Engl J Med (1986) 1.94
Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol (1996) 1.94
Lipoprotein analysis in the evaluation of chest pain in the emergency department. Mayo Clin Proc (1991) 1.92
Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation (1999) 1.81
Breast cancer risk factors among screening program participants. J Natl Cancer Inst (1979) 1.81
A survey of 246 suggested coronary risk factors. Atherosclerosis (1981) 1.76
Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol (1989) 1.73
Bias of the contribution of single-locus effects to the variance of a quantitative trait. Am J Hum Genet (1986) 1.65
Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males. Circulation (1998) 1.65
Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. Genetics (2000) 1.64
Identifying pedigrees segregating at a major locus for a quantitative trait: an efficient strategy for linkage analysis. Am J Hum Genet (1989) 1.62
Some genetic programs to supplement self-instruction in FORTRAN. Am J Hum Genet (1967) 1.60
Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. J Biol Chem (1990) 1.57
Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N Engl J Med (1983) 1.56
Detection of heart calcification with electron beam CT: interobserver and intraobserver reliability for scoring quantification. Radiology (1994) 1.55
Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin. Mayo Clin Proc (1991) 1.54
Magnified risks from cigarette smoking for coronary prone families in Utah. West J Med (1984) 1.53
Coronary artery calcification detected with ultrafast CT as an indication of coronary artery disease. Radiology (1992) 1.51
Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II. Hypertension (1998) 1.51
Validity of cigarette smoking habits in three epidemiologic studies in Utah. Prev Med (1989) 1.51
Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects. Antimicrob Agents Chemother (1997) 1.50
Low-dose, time-release nicotinic acid: effects in selected patients with low concentrations of high-density lipoprotein cholesterol. Mayo Clin Proc (1992) 1.46
Studies on genetic selection in a completely ascertained caucasian population. II. Family analyses of 11 blood group systems. Am J Hum Genet (1971) 1.46
Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science (1982) 1.46
Apolipoprotein A-II levels and coronary artery disease in subjects with and without diabetes: a study with use of a specific radioimmunoassay for apolipoprotein A-II. Mayo Clin Proc (1993) 1.45
Studies on genetic selection in a completely ascertained caucasian population. I. Frequencies, age and sex effects, and phenotype associations for 12 blood group systems. Am J Hum Genet (1971) 1.44
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. III. Identification of genetic effects using 12 polymorphic genetic blood marker systems. Am J Hum Genet (1976) 1.42
Nonclinical factors associated with surgery received for treatment of early-stage breast cancer. Am J Public Health (1992) 1.42
Environmental determinants of urinary kallikrein excretion. Am J Hypertens (1993) 1.42
Management of lipids in primary and secondary prevention of cardiovascular diseases. Mayo Clin Proc (1988) 1.42
Estimation of genetic model parameters: variables correlated with a quantitative phenotype exhibiting major locus inheritance. Genet Epidemiol (1989) 1.40
Evaluation of arterialized vein graft permeability with Evans blue dye and iodine 125-labeled albumin. Ann Thorac Surg (1989) 1.40
Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees. JAMA (1986) 1.39
Myocardial infarction risk, earlobe crease, and sleep apnoea syndrome. Lancet (1989) 1.39
Studies of isozyme patterns in nullisomic-tetrasomic combinations of hexaploid wheat. Proc Natl Acad Sci U S A (1969) 1.38
IMPAIRMENT OF REPRODUCTION IN RATS BY INGESTION OF LEAD. Science (1945) 1.38
Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation (2000) 1.36
Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation (1995) 1.35
Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet (1992) 1.34
A DNA probe for the LDL receptor gene is tightly linked to hypercholesterolemia in a pedigree with early coronary disease. Am J Hum Genet (1986) 1.32
Genetic linkage between lipoprotein(a) phenotype and a DNA polymorphism in the plasminogen gene. Genomics (1988) 1.31
Genetic determination of plasma apolipoprotein AI in a population-based sample. Am J Hum Genet (1989) 1.29
Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age. Hypertension (1989) 1.28
Cardiovascular mortality in Mormons and non-Mormons in Utah, 1969--1971. Am J Epidemiol (1978) 1.26
Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. Science (1984) 1.26
Pathologic changes in aortocoronary saphenous vein grafts. Am J Cardiol (1974) 1.25
The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet (1991) 1.25
Response to antituberculous chemotherapy after splenectomy. J Intern Med (1993) 1.25
Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease. Clin Chem (1994) 1.24
Identification and relative weight of cardiovascular risk factors. Cardiol Clin (1986) 1.24
The genetic linkage relations of adenylate kinase: further data on the ABO-AK linkage group. Am J Hum Genet (1969) 1.23
Comparison of sequential and fixed-structure sampling of pedigrees in complex segregation analysis of a quantitative trait. Am J Hum Genet (1988) 1.23
Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. Arterioscler Thromb (1991) 1.22
Identification of a factor in fetal bovine serum that stabilizes the cumulus extracellular matrix. A role for a member of the inter-alpha-trypsin inhibitor family. J Biol Chem (1992) 1.21
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. V. Variance components estimated from pedigrees. Ann Hum Genet (1979) 1.21
Expressed hypervariable polymorphism of apolipoprotein (a). Am J Hum Genet (1991) 1.20
Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-milligram and 1-gram doses of levofloxacin in healthy volunteers. Antimicrob Agents Chemother (1998) 1.19
Lack of association of diagonal earlobe crease with other cardiovascular risk factors. West J Med (1984) 1.18
Evidence for a third genetic locus causing familial hypercholesterolemia. A non-LDLR, non-APOB kindred. J Lipid Res (1999) 1.17
Apolipoprotein E phenotyping with a single gel method: application to the study of informative matings. J Lipid Res (1983) 1.17
The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet (1992) 1.16
Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity. J Hypertens (1996) 1.16