Published in Nature on February 24, 1983
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science (2008) 4.50
Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proc Natl Acad Sci U S A (1985) 4.04
Isolation and characterization of the human apolipoprotein A-I gene. Proc Natl Acad Sci U S A (1983) 2.42
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest (1986) 1.96
Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. Proc Natl Acad Sci U S A (1984) 1.91
Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia. J Clin Invest (1985) 1.73
Gene structure of human apolipoprotein A1. Nucleic Acids Res (1983) 1.58
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The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? J Lipid Res (2010) 1.36
Construction and identification of mouse amelogenin cDNA clones. Proc Natl Acad Sci U S A (1983) 1.29
Genetic determination of plasma apolipoprotein AI in a population-based sample. Am J Hum Genet (1989) 1.29
DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis. Proc Natl Acad Sci U S A (1987) 1.28
Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions. J Lipid Res (2010) 1.21
Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro. J Clin Invest (1992) 1.11
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Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA. Proc Natl Acad Sci U S A (1984) 1.06
Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism. Proc Natl Acad Sci U S A (1986) 1.01
Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc Natl Acad Sci U S A (1986) 1.00
The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering. J Biol Chem (2011) 0.95
Genetic basis of lipoprotein disorders. J Clin Invest (1989) 0.93
Apoproteins: determinants of lipoprotein metabolism and indices of coronary risk. Br Heart J (1984) 0.92
Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior. J Clin Invest (1994) 0.92
Familial apolipoprotein AI and apolipoprotein CIII deficiency. Subclass distribution, composition, and morphology of lipoproteins in a disorder associated with premature atherosclerosis. J Clin Invest (1984) 0.92
Dual tissue-specific expression of apo-AII is directed by an upstream enhancer. Nucleic Acids Res (1987) 0.87
Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans. J Lipid Res (2014) 0.84
The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance. Proc Natl Acad Sci U S A (1985) 0.81
Molecular approaches to dysmorphology. J Med Genet (1988) 0.78
Do mutations causing low HDL-C promote increased carotid intima-media thickness? Clin Chim Acta (2006) 0.78
Apolipoprotein A-I gene polymorphism and susceptibility of non-insulin-dependent diabetes mellitus. Am J Hum Genet (1985) 0.75
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb (1994) 8.54
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48
Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med (1993) 5.19
Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proc Natl Acad Sci U S A (1985) 4.04
Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol (1998) 3.66
Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A (1994) 3.24
ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb (1994) 3.11
Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA (1988) 3.04
Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science (1990) 3.04
The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron. J Biol Chem (1987) 2.85
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
Adrenoleukodystrophy: evidence for X linkage, inactivation, and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A (1981) 2.83
Lipoprotein(a) reduction by N-acetylcysteine. Lancet (1991) 2.81
Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest (1992) 2.80
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet (2001) 2.73
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol (1992) 2.72
Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation (2001) 2.71
Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science (1991) 2.70
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry (1981) 2.61
Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest (1995) 2.48
Isolation and characterization of the human apolipoprotein A-I gene. Proc Natl Acad Sci U S A (1983) 2.42
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol (1985) 2.35
Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest (1995) 2.27
High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J Biol Chem (1989) 2.17
Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation (1997) 2.10
Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest (1996) 2.10
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest (1995) 2.05
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res (1982) 2.01
Noninvasive In vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice. Circulation (1998) 1.94
Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. Proc Natl Acad Sci U S A (1984) 1.91
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet (1993) 1.90
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.85
Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature (1989) 1.85
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1999) 1.84
An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms. Proc Natl Acad Sci U S A (1993) 1.83
A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways. Mol Cell Biol (1991) 1.80
Differential expression of steroid sulphatase locus on active and inactive human X chromosome. Nature (1982) 1.75
Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci U S A (1998) 1.73
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. N Engl J Med (1986) 1.70
Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse. Proc Natl Acad Sci U S A (1991) 1.68
Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered (2001) 1.67
Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease. N Engl J Med (1982) 1.67
Linkage of human apolipoproteins A-I and C-III genes. Nature (1983) 1.66
Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci U S A (1982) 1.66
Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J Clin Invest (1992) 1.66
Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. J Biol Chem (1988) 1.64
Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem (1999) 1.64
Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice. J Biol Chem (1991) 1.63
Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia. J Clin Invest (1998) 1.63
Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. N Engl J Med (1986) 1.55
Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene. J Clin Invest (1989) 1.55
Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription. J Biol Chem (1993) 1.54
Human apolipoprotein E isoprotein subclasses are genetically determined. Am J Hum Genet (1981) 1.54
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem (1985) 1.54
Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry (1981) 1.51
Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes. J Clin Invest (1996) 1.49
The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms. EMBO J (1986) 1.49
Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. J Biol Chem (1997) 1.49
Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination. J Biol Chem (1989) 1.47
Type of alcoholic beverage and risk of myocardial infarction. Am J Cardiol (1999) 1.46
Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. J Intern Med (2011) 1.46
Synthesis, intracellular processing, and signal peptide of human apolipoprotein E. J Biol Chem (1984) 1.45
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. J Clin Invest (1987) 1.45
Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes. J Biol Chem (1986) 1.44
HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels. Circulation (1989) 1.43
Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid. Mol Cell Biol (1992) 1.43
Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A (1996) 1.42
Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia. J Clin Invest (1991) 1.42
Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women. J Clin Invest (1989) 1.40
Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels. J Lipid Res (1994) 1.40
Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler Thromb (1994) 1.40
ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res (1997) 1.39
N-acetylcysteine and lipoprotein(a) Lancet (1992) 1.38
A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest (1990) 1.37
Physical exercise and reduced risk of nonfatal myocardial infarction. Am J Epidemiol (1995) 1.37
Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange. Br Med J (Clin Res Ed) (1985) 1.37
Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr (1995) 1.36
Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (1996) 1.35
Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types. Mol Cell Biol (1988) 1.35
Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes. Mol Cell Biol (1988) 1.35
Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome. Surgery (1990) 1.34
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest (1987) 1.33
DNA polymorphism haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster. Hum Genet (1988) 1.32
Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles. J Lipid Res (1985) 1.31