Published in Arch Biochem Biophys on June 01, 1987
Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes. Environ Sci Technol (2011) 1.04
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Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. Toxicol Sci (2001) 2.51
The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics (2001) 2.21
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Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Toxicol Appl Pharmacol (1996) 1.39
Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide. Reprod Toxicol (1995) 1.36
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Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol Appl Pharmacol (2000) 1.21
Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod Toxicol (1999) 1.18
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Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. Toxicol Appl Pharmacol (1996) 1.15
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cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol (2001) 1.11
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Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet (1998) 1.04
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Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol Appl Pharmacol (1993) 1.02
Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes. Drug Metab Dispos (1996) 1.02
Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility. J Pharmacol Exp Ther (1999) 1.01
Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp Mol Pathol (1973) 1.01
In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol Appl Pharmacol (1984) 1.01
Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans. Drug Metab Dispos (2002) 1.01
Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis. Biochemistry (1997) 1.00
Biliary epithelial cell proliferation following alpha-naphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction. Fundam Appl Toxicol (1995) 1.00
Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450. Life Sci (1977) 1.00
Dermal absorption of phthalate diesters in rats. Fundam Appl Toxicol (1989) 1.00
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol (2002) 1.00
alpha-Naphthylisothiocyanate induced alterations in hepatic drug metabolizing enzymes and liver morphology: implications concerning anticarcinogenesis. Carcinogenesis (1981) 0.99
Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol. Mutat Res (2000) 0.99
Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane. J Pharmacol Exp Ther (1980) 0.98
Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model. Toxicol Pathol (2001) 0.97
Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies. Chem Res Toxicol (1995) 0.97
The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol. Toxicol Appl Pharmacol (1996) 0.97
A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles. Toxicol Appl Pharmacol (1999) 0.96
Molecular basis for a functionally unique cytochrome P450IIB1 variant. J Biol Chem (1991) 0.95
Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11. Biochim Biophys Acta (1997) 0.95
Circadian alterations in prolactin, corticosterone, and thyroid hormone levels and down-regulation of prolactin receptor activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (1987) 0.94
Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispos (1985) 0.94
Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. Drug Metab Dispos (1984) 0.94
Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharmacol Exp Ther (1980) 0.93
Preparation and composition of alveolar extracellular matrix and incorporated basement membrane. Lung (1981) 0.93
Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol (1999) 0.93
Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants. Biochemistry (1998) 0.93
Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. Arch Biochem Biophys (1996) 0.93
Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling. J Pharmacol Exp Ther (1999) 0.92
The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins. Arch Biochem Biophys (2001) 0.92
Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites. Biochemistry (1994) 0.92
Pharmacokinetics of acrylamide in Fisher-344 rats. Toxicol Appl Pharmacol (1982) 0.92
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione. Anesthesiology (1974) 0.92
Characterization of the hepatic DNA damage caused by 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis (1981) 0.91
Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides. Chem Res Toxicol (1996) 0.91
Risk assessment of chemical mixtures: biologic and toxicologic issues. Fundam Appl Toxicol (1993) 0.91
2,4,5,2',4',5'-Hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol (1982) 0.91
On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem (1985) 0.91
Sensitive gas chromatographic determination of trifluoperazine in human plasma. J Chromatogr (1981) 0.90
Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles. Mol Pharmacol (2001) 0.90
In vitro degradation of L-phenylalanine mustard (L-PAM). Cancer Chemother Pharmacol (1982) 0.90
Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes. Drug Metab Dispos (1997) 0.90
Stoichiometry of 7-ethoxycoumarin metabolism by cytochrome P450 2B1 wild-type and five active-site mutants. FEBS Lett (1997) 0.90
Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase. Arch Biochem Biophys (1994) 0.90
Biotransformation and hepatotoxicity of halothane. Biochem Pharmacol (1977) 0.90
Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). Arch Biochem Biophys (2000) 0.90
Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450. Life Sci (1997) 0.89
Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes. Mol Pharmacol (2001) 0.89
Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice. Drug Metab Dispos (1994) 0.89
Reactions of peroxynitrite with gamma-tocopherol. Chem Res Toxicol (1997) 0.88
A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food Chem Toxicol (2003) 0.88
Alterations in DNA-dependent RNA polymerase I and II from rat liver by thioacetamide: preferential increase in the level of chromatin-associated nucleolar RNA polymerase IB. Biochemistry (1977) 0.88
The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4. Arch Biochem Biophys (2000) 0.88
Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos (2009) 0.88
Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. Biochemistry (1998) 0.88
Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy. Drug Metab Dispos (1998) 0.88
Substrate-regulated, cAMP-dependent phosphorylation, denaturation, and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1. J Biol Chem (1994) 0.88
The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity. Toxicol Appl Pharmacol (1991) 0.88
Some cardiovascular and autonomic effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1971) 0.87
Central nervous system effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1972) 0.87
Effects of adenine nucleosides on RNA synthesis in adenovirus-infected cells. 9-beta-D-Arabinofuranosyladenine as a selective inhibitor of RNA polyadenylation. Mol Pharmacol (1982) 0.87
Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol Appl Pharmacol (1980) 0.87
Selective suppression of rat hepatic cytochrome P450 2C11 by chloramphenicol. J Pharmacol Exp Ther (1994) 0.87
Reduced ability of rat preantral ovarian follicles to metabolize 4-vinyl-1-cyclohexene diepoxide in vitro. Toxicol Appl Pharmacol (1994) 0.86
Regulation of substance P by nerve growth factor: disruption by capsaicin. Brain Res (1982) 0.86
Ranitidine-acetaminophen interaction: effects on acetaminophen-induced hepatotoxicity in Fischer 344 rats. Hepatology (1985) 0.86
Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes. Arch Biochem Biophys (2000) 0.86
Comparison of hepatic carcinogen initiation-promotion systems. Carcinogenesis (1982) 0.86
Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1. Biochemistry (1992) 0.85
Comparison of random and serial sections in assessment of ovarian toxicity. Reprod Toxicol (1991) 0.85
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration. Toxicol Appl Pharmacol (1983) 0.85