Published in Mutat Res on September 20, 2000
Antitumor phenylpropanoids found in essential oils. Biomed Res Int (2015) 0.85
Human consumption of methyleugenol and its elimination from serum. Environ Health Perspect (2004) 0.85
Use of biomonitoring data to evaluate methyl eugenol exposure. Environ Health Perspect (2006) 0.84
Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells. J Nutr Metab (2013) 0.77
Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenol. Genes Environ (2016) 0.76
Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase. Sci Rep (2017) 0.75
Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. Toxicol Sci (2001) 2.51
Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Toxicol Appl Pharmacol (1996) 1.39
Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide. Reprod Toxicol (1995) 1.36
Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades. Biol Reprod (2001) 1.28
Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats. Biol Reprod (2001) 1.26
Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol Appl Pharmacol (2000) 1.21
Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod Toxicol (1999) 1.18
The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity. Toxicol Appl Pharmacol (1990) 1.18
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes. Biochem Pharmacol (1983) 1.16
Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. Toxicol Appl Pharmacol (1996) 1.15
Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber. Drug Metab Dispos (2000) 1.12
Evaluation of certain food additives and contaminants. World Health Organ Tech Rep Ser (2007) 1.06
An animal model of hepatotoxicity associated with halothane anesthesia. Anesthesiology (1976) 1.06
Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu Rev Pharmacol Toxicol (1996) 1.06
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology (1979) 1.02
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. Toxicol Appl Pharmacol (1993) 1.02
Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes. Drug Metab Dispos (1996) 1.02
In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol Appl Pharmacol (1984) 1.01
Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp Mol Pathol (1973) 1.01
Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans. Drug Metab Dispos (2002) 1.01
Dermal absorption of phthalate diesters in rats. Fundam Appl Toxicol (1989) 1.00
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol (2002) 1.00
Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450. Life Sci (1977) 1.00
Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane. J Pharmacol Exp Ther (1980) 0.98
Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model. Toxicol Pathol (2001) 0.97
The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol. Toxicol Appl Pharmacol (1996) 0.97
A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles. Toxicol Appl Pharmacol (1999) 0.96
Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispos (1985) 0.94
Circadian alterations in prolactin, corticosterone, and thyroid hormone levels and down-regulation of prolactin receptor activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (1987) 0.94
Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. Drug Metab Dispos (1984) 0.94
Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharmacol Exp Ther (1980) 0.93
Preparation and composition of alveolar extracellular matrix and incorporated basement membrane. Lung (1981) 0.93
Pharmacokinetics of acrylamide in Fisher-344 rats. Toxicol Appl Pharmacol (1982) 0.92
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione. Anesthesiology (1974) 0.92
Characterization of the hepatic DNA damage caused by 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis (1981) 0.91
Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides. Chem Res Toxicol (1996) 0.91
Risk assessment of chemical mixtures: biologic and toxicologic issues. Fundam Appl Toxicol (1993) 0.91
2,4,5,2',4',5'-Hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol (1982) 0.91
Sensitive gas chromatographic determination of trifluoperazine in human plasma. J Chromatogr (1981) 0.90
In vitro degradation of L-phenylalanine mustard (L-PAM). Cancer Chemother Pharmacol (1982) 0.90
Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis. Proc Natl Acad Sci U S A (1971) 0.90
Biotransformation and hepatotoxicity of halothane. Biochem Pharmacol (1977) 0.90
Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice. Drug Metab Dispos (1994) 0.89
Congenital bone anomalies associated with lipomas. Skeletal Radiol (1985) 0.89
Reactions of peroxynitrite with gamma-tocopherol. Chem Res Toxicol (1997) 0.88
A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food Chem Toxicol (2003) 0.88
Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos (2009) 0.88
The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity. Toxicol Appl Pharmacol (1991) 0.88
Some cardiovascular and autonomic effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1971) 0.87
Developmental expression of N-acetyltransferases in C57BI/6 mice. Drug Metab Dispos (1999) 0.87
Central nervous system effects of fenfluramine hydrochloride. J Pharmacol Exp Ther (1972) 0.87
Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol Appl Pharmacol (1980) 0.87
Reduced ability of rat preantral ovarian follicles to metabolize 4-vinyl-1-cyclohexene diepoxide in vitro. Toxicol Appl Pharmacol (1994) 0.86
Regulation of substance P by nerve growth factor: disruption by capsaicin. Brain Res (1982) 0.86
Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Arch Biochem Biophys (1987) 0.86
Comparison of random and serial sections in assessment of ovarian toxicity. Reprod Toxicol (1991) 0.85
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration. Toxicol Appl Pharmacol (1983) 0.85
Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. Mutat Res (1989) 0.85
Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Reprod Toxicol (1996) 0.85
Long-term ovarian and gonadotropin changes in mice exposed to 4-vinylcyclohexene. Reprod Toxicol (1994) 0.85
Enhanced hepatic microsomal activity by pretreatment of rats with acetone or isopropanol. Proc Soc Exp Biol Med (1973) 0.84
Comparison of the disposition and in vitro metabolism of 4-vinylcyclohexene in the female mouse and rat. Toxicol Appl Pharmacol (1990) 0.84
Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol (1974) 0.83
Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats. Drug Metab Dispos (2009) 0.83
The disposition of acrylic acid in the male Sprague-Dawley rat following oral or topical administration. Food Chem Toxicol (1993) 0.83
A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food Chem Toxicol (2010) 0.83
Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity. Toxicology (1997) 0.83
Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol. Toxicol Appl Pharmacol (1975) 0.83
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol Appl Pharmacol (1993) 0.83
Comparative effects of folate antagonists versus enzymatic folate depletion on folate and thymidine enzymes in cultured mammalian cells. Cancer Treat Rep (1977) 0.83
The genotoxicity of 4,4'-methylenebis-2-chloroaniline in rat, mouse, and hamster hepatocytes. Toxicol Appl Pharmacol (1981) 0.83
Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat. Toxicology (1997) 0.83
Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat-hepatocyte cultures. Xenobiotica (1984) 0.83
Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A. Cell Biol Toxicol (2000) 0.83
Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F1 mice and Sprague-Dawley rats. Toxicology (1996) 0.83
Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide. J Toxicol Environ Health (1994) 0.82
Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents. Environ Health Perspect (1994) 0.82
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food Chem Toxicol (2005) 0.82
Prediction of metabolic clearance of bisphenol A (4,4 '-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes. Drug Metab Dispos (2007) 0.82
N-Acetylation of drugs. A genetically controlled reciprocal relationship between drug N-acetylating enzymes of rabbit liver and peripheral blood cells. Drug Metab Dispos (1978) 0.82
Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices. Hum Exp Toxicol (1995) 0.82
2,3,6,2',3',6'-hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol (1982) 0.82
Inhibition of ornithine decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol (1982) 0.81
Evidence for the metabolism of bumetanide in man. Life Sci (1975) 0.81
Deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane. Toxicol Appl Pharmacol (1983) 0.81
Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol Appl Pharmacol (1985) 0.81
Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. Drug Metab Dispos (2001) 0.81
Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes. Proc Natl Acad Sci U S A (1982) 0.81
Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats. Toxicology (2007) 0.81
Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. Proc Natl Acad Sci U S A (1976) 0.81
Inhibition of NADPH oxidation and related drug oxidation in liver microsomes by zinc. Biochem Pharmacol (1976) 0.81
The bioactivation of 1,2-dibromoethane in rat hepatocytes: covalent binding to nucleic acids. Carcinogenesis (1982) 0.80
Role of the acetylation polymorphism in determining susceptibility of cultured rabbit hepatocytes to DNA damage by aromatic amines. Cancer Res (1983) 0.80
A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients. Food Chem Toxicol (2011) 0.80
Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J Toxicol Environ Health (1986) 0.80
Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcyclohexene. Life Sci (2001) 0.80
Altered retrograde axonal transport of nerve growth factor after single and repeated doses of acrylamide in the rat. Toxicol Appl Pharmacol (1983) 0.80