Published in Proc Natl Acad Sci U S A on January 01, 1988
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci U S A (1994) 3.09
Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells. Infect Immun (1992) 2.73
Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. J Cell Biol (1989) 2.67
Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J Cell Biol (1989) 2.63
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci U S A (1994) 2.41
Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J Cell Biol (1993) 2.26
Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells. J Cell Biol (1990) 2.16
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain. J Cell Biol (1998) 2.12
Regulation of the VLA integrin-ligand interactions through the beta 1 subunit. J Cell Biol (1992) 1.96
The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J Exp Med (1989) 1.78
A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul (1990) 1.69
Leukocyte function-associated antigen 1 is an activation molecule for human T cells. J Exp Med (1989) 1.69
Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event. J Cell Biol (1989) 1.63
An alternative cytoplasmic domain of the integrin beta 3 subunit. Proc Natl Acad Sci U S A (1989) 1.61
Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin. J Cell Biol (1989) 1.60
Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat. J Cell Biol (1990) 1.57
Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol Biol Cell (1997) 1.54
Cell-matrix adhesions differentially regulate fascin phosphorylation. Mol Biol Cell (1999) 1.52
Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts. J Cell Biol (1991) 1.51
Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction. J Exp Med (1995) 1.47
TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol (2015) 1.45
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell (1993) 1.45
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med (1993) 1.40
Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences. J Exp Med (1994) 1.39
Opening-up of liposomal membranes by talin. Proc Natl Acad Sci U S A (1998) 1.38
Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J Cell Biol (1998) 1.37
Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ. J Cell Biol (1994) 1.36
Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Mol Biol Cell (1995) 1.36
Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion. J Exp Med (1992) 1.31
Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum. J Cell Biol (1988) 1.29
Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes. J Cell Biol (1992) 1.28
Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets. J Cell Biol (1989) 1.25
Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans. Mol Biol Cell (1996) 1.25
Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1. Proc Natl Acad Sci U S A (1993) 1.25
Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes. J Cell Biol (1989) 1.23
Kinetics of cell detachment: peeling of discrete receptor clusters. Biophys J (1994) 1.23
Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium. Blood (2005) 1.22
Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells. Mol Biol Cell (1997) 1.19
Dynamic interactions of macrophages with T cells during antigen presentation. J Exp Med (1999) 1.16
Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta (2013) 1.03
Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1. Biophys J (1992) 1.03
Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms. J Cell Biol (1990) 0.97
G10BP, an E1A-inducible negative regulator of Sp1, represses transcription of the rat fibronectin gene. Mol Cell Biol (1995) 0.89
PDGF stimulation induces phosphorylation of talin and cytoskeletal reorganization in skeletal muscle. J Cell Biol (1993) 0.89
Phorbol myristate acetate inhibits HeLa 229 invasion by Bordetella pertussis and other invasive bacterial pathogens. Infect Immun (1990) 0.86
The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells. Proc Natl Acad Sci U S A (1996) 0.83
Normal and abnormal secretion by haemopoietic cells. Immunology (2001) 0.82
Molecular analysis of antigen-independent adhesion forces between T and B lymphocytes. Proc Natl Acad Sci U S A (1994) 0.80
Adhesion of a chicken myeloblast cell line to fibrinogen and vitronectin through a beta 1-class integrin. J Cell Biol (1992) 0.80
The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. Br J Pharmacol (2014) 0.80
Induction of Sp1 in differentiating human embryonal carcinoma cells triggers transcription of the fibronectin gene. Mol Cell Biol (1998) 0.78
Concanavalin A amplifies both beta-adrenergic and muscarinic cholinergic receptor-adenylate cyclase-linked pathways in cardiac myocytes. J Clin Invest (1991) 0.78
The fluid mosaic model of the structure of cell membranes. Science (1972) 37.43
Integrins: a family of cell surface receptors. Cell (1987) 21.14
Studies and perspectives of protein kinase C. Science (1986) 14.73
A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells. Cell (1979) 8.80
Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature (1986) 8.06
The molecular organization of membranes. Annu Rev Biochem (1974) 7.13
Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol (1987) 5.69
Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell (1987) 4.70
Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interaction. Adv Immunol (1976) 4.18
Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts. J Cell Biol (1982) 3.92
A new protein of adhesion plaques and ruffling membranes. J Cell Biol (1983) 3.88
Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin". J Biol Chem (1987) 3.87
Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases. Proc Natl Acad Sci U S A (1986) 3.84
Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture. J Cell Biol (1985) 3.76
An interaction between vinculin and talin. Nature (1984) 3.51
The participation of alpha-actinin in the capping of cell membrane components. Cell (1979) 2.58
Monoclonal antibodies which alter the morphology of cultured chick myogenic cells. J Cell Biochem (1982) 2.49
Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. Curr Top Microbiol Immunol (1983) 2.32
Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A (1986) 1.98
Immunocytochemical localization of 140 kD cell adhesion molecules in cultured chicken fibroblasts, and in chicken smooth muscle and intestinal epithelial tissues. J Histochem Cytochem (1985) 1.46
Properties of talin from chicken gizzard smooth muscle. J Biol Chem (1987) 1.40
Phosphorylation of the cytoskeletal protein talin by protein kinase C. Biochem Biophys Res Commun (1986) 1.19
An integral glycoprotein associated with the membrane attachment sites of actin microfilaments. J Cell Biol (1985) 1.04
The fluid mosaic model of the structure of cell membranes. Science (1972) 37.43
Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 14.14
Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc Natl Acad Sci U S A (1974) 7.95
The molecular organization of membranes. Annu Rev Biochem (1974) 7.13
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med (1995) 6.50
Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci U S A (1978) 5.91
Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (1981) 5.74
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 5.48
Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes. Proc Natl Acad Sci U S A (1980) 4.90
Improved procedures for immunoferritin labeling of ultrathin frozen sections. J Cell Biol (1976) 4.58
Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells. Proc Natl Acad Sci U S A (1975) 4.38
Antibody-induced linkages of plasma membrane proteins to intracellular actomyosin-containing filaments in cultured fibroblasts. Proc Natl Acad Sci U S A (1977) 4.23
Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound. Proc Natl Acad Sci U S A (1982) 4.17
Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells. J Cell Biol (1981) 4.15
Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands. Proc Natl Acad Sci U S A (1977) 4.04
Passage of an integral membrane protein, the vesicular stomatitis virus glycoprotein, through the Golgi apparatus en route to the plasma membrane. Proc Natl Acad Sci U S A (1981) 3.95
Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts. J Cell Biol (1982) 3.92
Ferritin-conjugated plant agglutinins as specific saccharide stains for electron microscopy: application to saccharides bound to cell membranes. Proc Natl Acad Sci U S A (1971) 3.90
Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc Natl Acad Sci U S A (1985) 3.76
Intracellular distributions of mechanochemical proteins in cultured fibroblasts. Proc Natl Acad Sci U S A (1977) 3.63
Associations of elements of the Golgi apparatus with microtubules. J Cell Biol (1984) 3.42
Reversion from transformed to normal phenotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.38
Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A (1980) 3.29
The directed migration of eukaryotic cells. Annu Rev Cell Biol (1986) 3.28
Selective modulation of protein kinase C-theta during T-cell activation. Nature (1997) 3.22
Protein conformation in cell membrane preparations as studied by optical rotatory dispersion and circular dichroism. Proc Natl Acad Sci U S A (1966) 3.16
Sequence and domain structure of talin. Nature (1990) 2.98
Antibody active sites and immunoglobulin molecules. Science (1966) 2.98
The localization of spectrin on the inner surface of human red blood cell membranes by ferritin-conjugated antibodies. J Cell Biol (1971) 2.96
Immunocytochemical localization of alpha-actinin in intestinal epithelial cells. Proc Natl Acad Sci U S A (1979) 2.86
Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc Natl Acad Sci U S A (1983) 2.85
Association of mitochondria with microtubules in cultured cells. Proc Natl Acad Sci U S A (1978) 2.85
Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu Rev Immunol (1989) 2.83
Ultrastructure of chicken cardiac muscle as studied by double immunolabeling in electron microscopy. Proc Natl Acad Sci U S A (1981) 2.76
Effect of microtubule assembly status on the intracellular processing and surface expression of an integral protein of the plasma membrane. J Cell Biol (1984) 2.68
Immunoelectron microscopic studies of the intracellular transport of the membrane glycoprotein (G) of vesicular stomatitis virus in infected Chinese hamster ovary cells. J Cell Biol (1983) 2.62
Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library. Proc Natl Acad Sci U S A (1989) 2.60
The participation of alpha-actinin in the capping of cell membrane components. Cell (1979) 2.58
On the mechanism of ATP-induced shape changes in human erythrocyte membranes. II. The role of ATP. J Cell Biol (1977) 2.54
An improved procedure for immunoelectron microscopy: ultrathin plastic embedding of immunolabeled ultrathin frozen sections. Proc Natl Acad Sci U S A (1984) 2.50
Membrane insertion at the leading edge of motile fibroblasts. Proc Natl Acad Sci U S A (1983) 2.45
Molecular biology of cellular membranes with applications to immunology. Adv Immunol (1974) 2.43
Alteration of the conformation of proteins in red blood cell membranes and in solution by fixatives used in electron microscopy. J Cell Biol (1968) 2.42
A general method for the specific staining of intracellular antigens with ferritin-antibody conjugates. Proc Natl Acad Sci U S A (1970) 2.31
Distribution of saccharide residues on membrane fragments from a myeloma-cell homogenate: its implications for membrane biogenesis. Proc Natl Acad Sci U S A (1972) 2.29
Detection and ultrastructural localization of human smooth muscle myosin-like molecules in human non-muscle cells by specific antibodies. Proc Natl Acad Sci U S A (1975) 2.29
The antibody-induced clustering and endocytosis of HLA antigens on cultured human fibroblasts. Cell (1980) 2.27
The processing pathway of prelamin A. J Cell Sci (1994) 2.25
Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc Natl Acad Sci U S A (1982) 2.23
Iron-dextran antibody conjugates: General method for simultaneous staining of two components in high-resolution immunoelectron microscopy. Proc Natl Acad Sci U S A (1979) 2.22
On the mechanism of ATP-induced shape changes in human erythrocyte membranes. I. The role of the spectrin complex. J Cell Biol (1977) 2.20
Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. Proc Natl Acad Sci U S A (1982) 2.18
Bifunctional imidoesters as cross-linking reagents. Biochem Biophys Res Commun (1966) 2.14
Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells. J Immunol (1984) 2.09
Concanavalin-A-induced transmembrane linkage of concanavalin A surface receptors to intracellular myosin-containing filaments. Proc Natl Acad Sci U S A (1976) 2.09
Immunoferritin localization of intracellular antigens: the use of ultracryotomy to obtain ultrathin sections suitable for direct immunoferritin staining. Proc Natl Acad Sci U S A (1973) 2.07
Market-based reform: what to regulate and by whom. Health Aff (Millwood) (1995) 2.04
Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc Natl Acad Sci U S A (1987) 2.04
Covalent labeling of active sites. Adv Protein Chem (1967) 2.03
Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A (1986) 1.98
The specific direct interaction of helper T cells and antigen-presenting B cells. Proc Natl Acad Sci U S A (1986) 1.98
On the nature of crossreactions observed with antibodies directed to defined epitopes. Proc Natl Acad Sci U S A (1982) 1.89
Interaction of filamin with f-actin in solution. Proc Natl Acad Sci U S A (1977) 1.87
Association of microtubules and intermediate filaments in chicken gizzard cells as detected by double immunofluorescence. Proc Natl Acad Sci U S A (1980) 1.87
Transmembrane linkage of fibronectin to intracellular actin-containing filaments in cultured human fibroblasts. Ann N Y Acad Sci (1978) 1.79
The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J Exp Med (1989) 1.78
Fibronectin is not present in the focal adhesions formed between normal cultured fibroblasts and their substrata. Proc Natl Acad Sci U S A (1980) 1.76
ON DISSOCIATION AND RECOMBINATION OF HUMAN ADULT HEMOGLOBINS A, S, AND C. Proc Natl Acad Sci U S A (1958) 1.71
Relationships of the spectrin complex of human erythrocyte membranes to the actomyosins of muscle cells. Biochemistry (1976) 1.70
Molecular changes in the membranes of mouse erythroid cells accompanying differentiation. Cell (1979) 1.66
Distributions of vimentin and desmin in developing chick myotubes in vivo. I. Immunofluorescence study. J Cell Biol (1984) 1.65
The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. J Mol Cell Immunol (1985) 1.62
Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc Natl Acad Sci U S A (2001) 1.61
Quantitative two-dimensional ultrastructural distribution of Rh o (D) antigenic sites on human erythrocyte membranes. Proc Natl Acad Sci U S A (1971) 1.60
Association of microtubules and intermediate filaments in normal fibroblasts and its disruption upon transformation by a temperature-sensitive mutant of Rous sarcoma virus. Proc Natl Acad Sci U S A (1981) 1.57
The mechanism of photoaffinity labeling. Proc Natl Acad Sci U S A (1973) 1.57
A single-payer system in Jackson Hole clothing. Health Aff (Millwood) (1994) 1.57
Lysosomes are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc Natl Acad Sci U S A (1984) 1.56
Mechanochemical proteins, cell motility and cell-cell contacts: the localization of mechanochemical proteins inside cultured cells at the edge of an in vitro "wound". J Cell Physiol (1979) 1.55
Anomalous interaction of the acetylcholine receptor protein with the nonionic detergent Triton X-114. Proc Natl Acad Sci U S A (1985) 1.54
The generation of antihapten antibodies with electrophoretically homogeneous L chains. Proc Natl Acad Sci U S A (1968) 1.52
Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranes. J Cell Biol (1976) 1.52
Participation of histocompatibility antigens in capping of molecularly independent cell surface components by their specific antibodies. Proc Natl Acad Sci U S A (1978) 1.51
The distribution and asymmetry of mammalian cell surface saccharides utilizing ferritin-conjugated plant agglutinins as specific saccharide stains. J Cell Biol (1974) 1.49
Immunocytochemical localization of 140 kD cell adhesion molecules in cultured chicken fibroblasts, and in chicken smooth muscle and intestinal epithelial tissues. J Histochem Cytochem (1985) 1.46
Phosphotyrosine-modified proteins are concentrated at the membranes of epithelial and endothelial cells during tissue development in chick embryos. J Cell Biol (1988) 1.46
On the transfer of integral proteins into membranes. Proc Natl Acad Sci U S A (1987) 1.45
Transmembrane interactions and the mechanisms of transport of proteins across membranes. J Supramol Struct (1978) 1.44
On the interactions of lipids and proteins in the red blood cell membrane. Proc Natl Acad Sci U S A (1970) 1.42