Published in J Pharmacol Exp Ther on December 01, 1978
Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicol Sci (2013) 0.90
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma. Invest New Drugs (2001) 0.85
Reactive metabolites in the biotransformation of molecules containing a furan ring. Chem Res Toxicol (2012) 0.78
Phenobarbital pretreatment protects against morphologic changes in rat bronchiolar epithelium caused by an impurity of malathion. Am J Pathol (1983) 0.75
New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst (1990) 23.46
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res (1988) 9.96
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res (1988) 8.53
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst (1989) 4.97
Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst (1990) 4.08
New soluble-formazan assay for HIV-1 cytopathic effects: application to high-flux screening of synthetic and natural products for AIDS-antiviral activity. J Natl Cancer Inst (1989) 4.04
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood (2001) 2.88
Morphological and immunocytochemical characteristics of human tumor cell lines for use in a disease-oriented anticancer drug screen. Anticancer Res (1992) 2.62
Solution structure of cyanovirin-N, a potent HIV-inactivating protein. Nat Struct Biol (1998) 2.19
To tell or not to tell: barriers and facilitators in family communication about genetic risk. Clin Genet (2003) 2.17
Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture. Antimicrob Agents Chemother (1987) 2.11
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res (1991) 2.06
Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a) J Med Chem (1995) 1.98
Development of human tumor cell line panels for use in disease-oriented drug screening. Prog Clin Biol Res (1988) 1.95
Tremorgenic toxin from Penicillium cyclopium grown on food materials. Nature (1968) 1.90
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. J Med Chem (1992) 1.89
Audit: the third clinical science? Qual Health Care (1992) 1.87
Glycolate Metabolism and Excretion by Chlamydomonas reinhardtii. Plant Physiol (1986) 1.85
Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. Mol Pharmacol (1976) 1.73
Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping. J Mol Biol (1999) 1.57
Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Thromb Haemost (2002) 1.52
Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. J Nat Prod (1998) 1.50
Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]. Antimicrob Agents Chemother (1989) 1.48
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs. Anticancer Drug Des (1995) 1.46
Toxins other than aflatoxins produced by Aspergillus flavus. Bacteriol Rev (1966) 1.46
Causative fungus agent of leucoencephalomalacia in equine animals. Vet Rec (1971) 1.44
Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration. Biochem Pharmacol (1968) 1.43
Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung. Nature (1977) 1.41
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. J Virol (1993) 1.41
GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene (2009) 1.37
Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp. J Med Chem (1991) 1.32
Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner. Mol Pharmacol (2001) 1.31
Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells. Cancer Res (1988) 1.29
Bioproduction and purification of rubratoxin B. Appl Microbiol (1968) 1.28
Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins. J Pharmacol Exp Ther (2001) 1.28
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis. J Nat Prod (1993) 1.26
Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV). Antiviral Res (1997) 1.26
Crystal structure of Escherichia coli HdeA. Nat Struct Biol (1998) 1.25
Oxathiin carboxanilide, a potent inhibitor of human immunodeficiency virus reproduction. Proc Natl Acad Sci U S A (1991) 1.24
Antineoplastic agents. 379. Synthesis of phenstatin phosphate. J Med Chem (1998) 1.23
Investigation of reported aflatoxin production by fungi outside the Aspergillus flavus group. Appl Microbiol (1968) 1.22
The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. Nucleic Acids Res (2003) 1.22
Production, isolation, and preliminary toxicity studies of brevianamide A from cultures of Penicillium viridicatum. Appl Microbiol (1973) 1.22
A semiautomated multiparameter approach for anti-HIV drug screening. J Virol Methods (1991) 1.21
Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Mol Biol Cell (1996) 1.21
HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana. J Nat Prod (1996) 1.19
Diverse effects of SKF 525-A and antioxidants on carbon tetrachloride-induced changes in liver microsomal P-450 content and ethylmorphine metabolism. Life Sci (1968) 1.19
Acute pulmonary injury in rats by nitrofurantoin and modification by vitamin E, dietary fat, and oxygen. Am Rev Respir Dis (1979) 1.18
HIV-inhibitory cembrane derivatives from a Philippines collection of the soft coral Lobophytum species. J Nat Prod (2000) 1.18
Vasectomy: immunologic effects in rhesus monkeys and men. Fertil Steril (1974) 1.17
Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells. Antimicrob Agents Chemother (1996) 1.17
Lack of correlation between natural killer activity and tumor growth control in nude mice with different immune defects. Cancer Res (1984) 1.15
Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. J Immunol (1988) 1.15
Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups. Antiviral Res (1995) 1.14
Cytochrome P-450 and its role in drug metabolism. Annu Rev Pharmacol (1972) 1.13
Profiles of prostaglandin biosynthesis in normal lung and tumor tissue from lung cancer patients. Cancer Res (1988) 1.13
AIDS-antiviral sulfolipids from cyanobacteria (blue-green algae). J Natl Cancer Inst (1989) 1.12
Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicol Sci (2005) 1.12
Thiazolinone analogues of indolmycin with antiviral and antibacterial activity. J Med Chem (1978) 1.10
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res (1992) 1.10
A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts. J Nat Prod (1993) 1.10
Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the republic of maldives cribrochalina species. J Nat Prod (2000) 1.10
The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam Appl Toxicol (1997) 1.09
Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii. J Nat Prod (1999) 1.09
Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41. Mol Pharmacol (2000) 1.09
High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis. Science (1979) 1.08
Siamenol, a new carbazole alkaloid from Murraya siamensis. J Nat Prod (2000) 1.07
Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19. J Nat Prod (1998) 1.06
A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem (1992) 1.05
Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra. J Nat Prod (2000) 1.05
Antineoplastic agents 365. Dolastatin 10 SAR probes. Anticancer Drug Des (1998) 1.04
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore. Bioorg Med Chem Lett (2001) 1.04
Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice. Xenobiotica (2006) 1.04
Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties. J Med Chem (1989) 1.03
Activity of mitozolomide (NSC 353451), a new imidazotetrazine, against xenografts from human melanomas, sarcomas, and lung and colon carcinomas. Cancer Res (1985) 1.03
Morphometric and colorimetric analyses of human tumor cell line growth and drug sensitivity in soft agar culture. Cancer Res (1991) 1.03
Ethnobotany and drug discovery: the experience of the US National Cancer Institute. Ciba Found Symp (1994) 1.03
In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. J Pharmacol Exp Ther (1982) 1.03
Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation. Crit Rev Toxicol (1980) 1.02
Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity. J Mol Biol (1999) 1.02
Recombinant production of cyanovirin-N, a potent human immunodeficiency virus-inactivating protein derived from a cultured cyanobacterium. Protein Expr Purif (1998) 1.02
Genetic services for hereditary breast/ovarian and colorectal cancers - physicians' awareness, use and satisfaction. Community Genet (2008) 1.01
Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors. Antimicrob Agents Chemother (1993) 1.01
Studies on the interaction of furan with hepatic cytochrome P-450. J Biochem Toxicol (1993) 1.01
Confirmation by chemical synthesis of the structure of 4-ipomeanol, a lung-toxic metabolite of the sweet potato, Ipomoea batatas. Nat New Biol (1972) 1.01
Virus-associated deficiencies in the mitogen reactivity in celebes black macaques (Macaca nigra). Clin Immunol Immunopathol (1985) 1.01
Prevalence of Bartonella species, Rickettsia felis, haemoplasmas and the Ehrlichia group in the blood of cats and fleas in eastern Australia. Aust Vet J (2010) 1.00
Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water. Biochem Biophys Res Commun (1982) 1.00
Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites. Biochem Biophys Res Commun (1977) 1.00
Anti-HIV prenylated flavonoids from Monotes africanus. J Nat Prod (2001) 1.00
Isolation, primary sequence determination, and disulfide bond structure of cyanovirin-N, an anti-HIV (human immunodeficiency virus) protein from the cyanobacterium Nostoc ellipsosporum. Biochem Biophys Res Commun (1997) 1.00
3H-Benzene metabolism in rabbit bone marrow. Life Sci (1979) 0.99
New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species. J Nat Prod (2001) 0.99
Dimethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A)--in vivo and in vitro effects of metabolism by rat liver microsomes--formation of an oxygenated complex. Biochem Pharmacol (1972) 0.99
Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans. Cancer Res (1993) 0.99