Published in Am J Physiol on February 01, 1988
Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase. Biochem J (1992) 1.17
Health implications of fructose consumption: A review of recent data. Nutr Metab (Lond) (2010) 1.15
A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes. BMC Med (2011) 0.90
Clinical research strategies for fructose metabolism. Adv Nutr (2014) 0.88
Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice. Diabetes Metab Res Rev (2008) 0.85
Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity. J Nutr Metab (2015) 0.81
Effects of fructose-containing caloric sweeteners on resting energy expenditure and energy efficiency: a review of human trials. Nutr Metab (Lond) (2013) 0.80
Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol (1979) 27.52
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care (1999) 26.39
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes (1981) 7.28
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med (1990) 7.13
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest (1985) 4.38
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest (1987) 4.26
Effect of fatty acids on glucose production and utilization in man. J Clin Invest (1983) 4.00
Glucose toxicity. Diabetes Care (1990) 3.82
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest (1989) 3.03
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest (1975) 2.97
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia (2003) 2.80
Effects of cardiogenic shock on lactate and glucose metabolism after heart surgery. Crit Care Med (2000) 2.49
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1982) 2.48
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes (1983) 2.45
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1996) 2.31
Glucose and insulin metabolism in uremia. Nephron (1992) 2.27
Indirect calorimetry: methodological and interpretative problems. Am J Physiol (1990) 2.14
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci U S A (1978) 2.08
Glucose intolerance and aging. Diabetes Care (1982) 2.07
Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes (1982) 2.06
Use of human-placental-lactogen radioimmunoassay to predict outcome in cases of threatened abortion. Lancet (1969) 2.04
The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes (1982) 2.01
Epinephrine-induced insulin resistance in man. J Clin Invest (1980) 1.98
Insulin resistance in uremia. J Clin Invest (1981) 1.98
Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int (2007) 1.95
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest (1987) 1.92
Hyperkalemia and hyporeninemic hypoaldosteronism. Kidney Int (1980) 1.91
The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes (1985) 1.88
The effects of glucose and insulin on renal electrolyte transport. J Clin Invest (1976) 1.84
Splanchnic and peripheral disposal of oral glucose in man. Diabetes (1983) 1.82
Effect of long chain triglyceride infusion on glucose metabolism in man. Metabolism (1982) 1.79
Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes (1987) 1.76
Obesity and insulin resistance in humans: a dose-response study. Metabolism (1990) 1.74
Retracted Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding. J Clin Invest (1978) 1.73
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia (1994) 1.73
The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia (1981) 1.68
The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism (1988) 1.60
Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes (1999) 1.60
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes (1992) 1.60
Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest (1981) 1.59
Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus. N Engl J Med (1991) 1.59
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. Am J Med (1983) 1.59
Suppression of alcohol-induced hypertension by dexamethasone. N Engl J Med (1995) 1.58
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1991) 1.57
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care (2001) 1.56
Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest (1978) 1.55
Bromocriptine: a novel approach to the treatment of type 2 diabetes. Diabetes Care (2000) 1.55
Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis. J Clin Invest (1987) 1.54
Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest (1985) 1.49
Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor. Science (1967) 1.49
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients. Diabetologia (2001) 1.48
Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis. Metabolism (1999) 1.48
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes (1996) 1.46
Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration. Diabetes (1980) 1.46
Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest (1993) 1.45
A 10-year survey of nutritional support in a surgical ICU: 1986-1995. Nutrition (1997) 1.44
Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements? Metabolism (1995) 1.44
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol (1983) 1.43
Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats. Diabetologia (1998) 1.43
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia (2004) 1.43
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp. J Reprod Med (1993) 1.40
Body fat and sympathetic nerve activity in healthy subjects. Circulation (1994) 1.38
Regulation of hepatic glucose metabolism in humans. Diabetes Metab Rev (1987) 1.37
Physical training and insulin sensitivity. Diabetes Metab Rev (1986) 1.37
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J Clin Invest (1993) 1.34
Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med (1979) 1.33
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol (1980) 1.32
Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man. J Clin Invest (1991) 1.31
Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest (1994) 1.28
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest (1991) 1.28
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol (1992) 1.25
Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Ann Intern Med (1985) 1.25
Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. J Clin Invest (1985) 1.25
Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. Diabetes Metab (2010) 1.24
Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Diabetes (1987) 1.24
Extrarenal potassium homeostasis. Am J Physiol (1981) 1.24
Insulin resistance in diabetic ketoacidosis. Diabetes (1982) 1.23
Glucose-induced thermogenesis in nondiabetic and diabetic obese subjects. Diabetes (1982) 1.23
The influence of age on the renal response to water deprivation in man. Nephron (1976) 1.23
Regulation of body weight in humans. Physiol Rev (1999) 1.22
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance. Diabetologia (2003) 1.22
Renal function in patients with multiple myeloma. Medicine (Baltimore) (1978) 1.22
Effect of dietary protein on in vivo insulin action and liver glycogen repletion. Am J Physiol (1989) 1.21
The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab (1982) 1.21
Time dependence of the interaction between lipid and glucose in humans. Am J Physiol (1989) 1.19
Proceedings: Cyclophosphamide and the kidney. Cancer (1974) 1.18
Carbohydrate metabolism in uremia: a review. Medicine (Baltimore) (1973) 1.17
Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol (1993) 1.15
Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am J Physiol (1989) 1.13
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol (1990) 1.13
Administration by nasal spray of an 18 amino acid synthetic polypeptide with corticotropic action. Experientia (1969) 1.13
Glucose transport in human skeletal muscle. The in vivo response to insulin. Diabetes (1993) 1.12