Published in Br J Anaesth on March 01, 1988
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Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol (1988) 7.06
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A (1982) 5.39
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem (1998) 5.09
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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science (1995) 4.23
Transforming activity of human tumor DNAs. Proc Natl Acad Sci U S A (1981) 4.02
Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell (1985) 3.86
Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant. J Med Genet (2008) 3.35
Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus. Cell (1981) 3.26
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Application of the Neufeld Reaction to the Identification of Types of Pneumococci -With the Use of Antisera for Thirty-Two Types. Am J Public Health Nations Health (1935) 3.13
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol Cell Biol (1997) 2.99
Definition of the human raf amino-terminal regulatory region by deletion mutagenesis. Mol Cell Biol (1989) 2.90
The benefits and pitfalls of pulse oximetry. BMJ (1993) 2.80
Infectious rous sarcoma virus and reticuloendotheliosis virus DNAs. J Virol (1974) 2.77
Transfection by exogenous and endogenous murine retrovirus DNAs. Cell (1979) 2.75
Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Mol Cell Biol (1988) 2.57
Rate-dependent induction phenomena with propofol: implications for the relative potency of intravenous anesthetics. Anesth Analg (1991) 2.52
ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol Cell Biol (1987) 2.48
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol (1990) 2.46
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol (1990) 2.42
Activation of related transforming genes in mouse and human mammary carcinomas. Proc Natl Acad Sci U S A (1981) 2.41
Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA. J Virol (1978) 2.38
Isolation of ras GTP-binding mutants using an in situ colony-binding assay. Proc Natl Acad Sci U S A (1986) 2.35
A comparison of remifentanil and alfentanil in patients undergoing major abdominal surgery. Anaesthesia (1997) 2.35
Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas. Cell (1983) 2.27
Dural taps revisited. A 20-year survey from Birmingham Maternity Hospital. Anaesthesia (1993) 2.26
Transforming activity of DNA of chemically transformed and normal cells. Nature (1980) 2.24
Obesity and obstetric anaesthesia. Anaesthesia (2006) 2.22
Bupivacaine versus bupivacaine plus fentanyl for epidural analgesia: effect on maternal satisfaction. BMJ (1991) 2.21
Selective decontamination of the digestive tract reduces gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation. Crit Care Med (1994) 2.21
Stage-specific transforming genes of human and mouse B- and T-lymphocyte neoplasms. Cell (1982) 2.20
Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus. Cell (1979) 2.17
Cardiac arrhythmias in children during outpatient general anaesthesia for dentistry: a prospective randomised trial. Lancet (1999) 2.12
Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation. Br J Anaesth (1971) 2.04
Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasms. Nature (1981) 2.03
Isoflurane compared with midazolam for sedation in the intensive care unit. BMJ (1989) 2.02
Phosphorylation of 5-bromodeoxycytidine in cells infected with herpes simplex virus. Proc Natl Acad Sci U S A (1973) 2.02
B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol (1999) 1.99
Lack of infectivity of the endogenous avian leukosis virus-related genes in the DNA of uninfected chicken cells. J Virol (1976) 1.99
Treatment of sympathetic overactivity in tetanus. Lancet (1969) 1.98
p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem (1997) 1.95
Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature (1980) 1.90
Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA. Nature (1983) 1.88
Studies of anaesthesia in relation to hypertension. I. Cardiovascular responses of treated and untreated patients. Br J Anaesth (1971) 1.87
Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse. EMBO J (1994) 1.80
Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21. Cell (1984) 1.76
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
rasH mutants deficient in GTP binding. Mol Cell Biol (1986) 1.73
Expression of c-mos RNA in germ cells of male and female mice. Proc Natl Acad Sci U S A (1987) 1.68
Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. Br J Anaesth (2006) 1.66
Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene (1996) 1.64
Transoesophageal echocardiography in anaesthesia and intensive care. Br J Anaesth (1996) 1.61
The influence of drugs used in neuroleptanalgesia on cardiovascular and ventilatory function. Br J Anaesth (1967) 1.61
Nausea and vomiting after gynaecological laparoscopy: comparison of premedication with oral ondansetron, metoclopramide and placebo. Br J Anaesth (1994) 1.59
Epidural analgesia and breastfeeding: a randomised controlled trial of epidural techniques with and without fentanyl and a non-epidural comparison group. Anaesthesia (2009) 1.59
Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas. Nature (1983) 1.58
Saving mothers' lives: reviewing maternal deaths to make motherhood safer: 2006-8: a review. Br J Anaesth (2011) 1.55
Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Intensive Care Med (2013) 1.52
Safer non-cardiac surgery for patients with coronary artery disease. Medical treatment should be optimised to improve outcome. BMJ (1998) 1.51
Sudden failure of swimming in cold water. Br Med J (1969) 1.50
Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene (1992) 1.48
Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg. Proc Natl Acad Sci U S A (1989) 1.48
Cellular transforming genes and oncogenesis. Biochim Biophys Acta (1984) 1.47
Induction and maintenance of propofol anaesthesia. A manual infusion scheme. Anaesthesia (1988) 1.44
Total i.v. anaesthesia with propofol and alfentanil for coronary artery bypass grafting. Br J Anaesth (1991) 1.43
An unexpected benefit of anaesthesia. Anaesthesia (1998) 1.43
Comparison of automatic oscillometric arterial pressure measurement with conventional auscultatory measurement in the labour ward. Br J Anaesth (1993) 1.42
Isolated systolic hypertension: pressure on the anaesthetist? Anaesthesia (2001) 1.41
Use of i.m. temperature probes during cardiopulmonary bypass in humans. Br J Anaesth (1995) 1.41
Selective inhibition of the replication of herpes simplex virus by 5-halogenated analogues of deoxycytidine. Mol Pharmacol (1975) 1.40
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol (1993) 1.40
Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences. Mol Cell Biol (1987) 1.39
Does a bloody tap prevent postdural puncture headache? Anaesthesia (1993) 1.39
Failed intubation in obstetric anaesthesia. Anaesthesia (2006) 1.37
The Ohmeda 9000 syringe pump. The first of a new generation of syringe drivers. Anaesthesia (1990) 1.36
Cardiovascular disturbances in severe tetanus due to overactivity of the sympathetic nervous system. Anaesthesia (1969) 1.30
Analgesic effects of sublingual buprenorphine. Anaesthesia (1979) 1.30
Linkage of the endogenous avian leukosis virus genome of virus-producing chicken cells to inhibitory cellular DNA sequences. Cell (1978) 1.30
Studies of anaesthesia in relation to hypertension. V. Adrenergic beta-receptor blockade. Br J Anaesth (1973) 1.28
Maternal deaths from anaesthesia. An extract from Why mothers die 1997-1999, the Confidential Enquiries into Maternal Deaths in the United Kingdom. Br J Anaesth (2002) 1.26
Determination of the in vivo carbon dioxide titration curve of anaesthetized man. Br J Anaesth (1966) 1.25
Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL. J Biol Chem (1996) 1.22
Effects of anesthesia on baroreflex control of heart rate in man. Anesthesiology (1969) 1.22
Isolation and characterization of a stage-specific transforming gene, Tlym-I, from T-cell lymphomas. Proc Natl Acad Sci U S A (1984) 1.20
A retroviral myc gene induces preneoplastic transformation of lymphocytes in a bursal transplantation assay. Proc Natl Acad Sci U S A (1985) 1.20
Transformation of NIH-3T3 mouse cells by avian retroviral DNAs. Cold Spring Harb Symp Quant Biol (1980) 1.20
Application of flow cytometric methods for the routine detection of Cryptosporidium and Giardia in water. Cytometry (1994) 1.18
Frequency of multiple Epstein-Barr virus infections in T-cell-immunocompromised individuals. J Virol (1996) 1.17
Observations during endobronchial anaesthesia. II. Oxygenation. Br J Anaesth (1974) 1.17
Unusual presentation of phaeochromocytoma. Management of anaesthesia and cardiovascular monitoring. Anaesthesia (1976) 1.17
Hemodynamic and hepatic effects of methohexital infusion during nitrous oxide anesthesia in humans. Anesth Analg (1983) 1.16
Factors influencing arterial PO2 during recovery from anaesthesia. Br J Anaesth (1968) 1.13
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Mol Cell Biol (1992) 1.11
Transfection by DNAs of avian erythroblastosis virus and avian myelocytomatosis virus strain MC29. J Virol (1980) 1.10
Circulatory influences of artificial ventilation during nitrous oxide anaesthesia in man. II. Results: the relative influence of mean intrathoracic pressure and arterial carbon dioxide tension. Br J Anaesth (1967) 1.09
Assay of noninfectious fragments of DNA of avian leukosis virus-infected cells by marker rescue. J Virol (1977) 1.09
An assessment of the Dinamap 845. Anaesthesia (1984) 1.09