Published in Proc Natl Acad Sci U S A on June 01, 1982
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Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52
New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol (1984) 3.43
Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Res (2010) 3.24
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci U S A (1982) 3.02
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A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins. Proc Natl Acad Sci U S A (1986) 2.32
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A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proc Natl Acad Sci U S A (1984) 2.24
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol Cell Biol (1991) 2.06
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci U S A (1983) 2.04
Direct identification of palmitic acid as the lipid attached to p21ras. Mol Cell Biol (1986) 2.02
Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discov (2011) 2.02
Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver. Mol Cell Biol (1984) 1.98
The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation. Mol Cell Biol (1987) 1.95
Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proc Natl Acad Sci U S A (1984) 1.94
RAS genes and growth control in Saccharomyces cerevisiae. J Bacteriol (1986) 1.92
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Spontaneous activation of a human proto-oncogene. Proc Natl Acad Sci U S A (1983) 1.90
Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. Mol Cell Biol (1986) 1.90
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A (1984) 1.89
Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes. Mol Cell Biol (1985) 1.85
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. Proc Natl Acad Sci U S A (1985) 1.83
Resistance of human cells to tumorigenesis induced by cloned transforming genes. Proc Natl Acad Sci U S A (1983) 1.79
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient. Proc Natl Acad Sci U S A (1984) 1.78
Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res (2010) 1.77
Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol (1987) 1.65
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice. Proc Natl Acad Sci U S A (1985) 1.61
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc Natl Acad Sci U S A (1985) 1.61
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
New mammalian transforming retrovirus: demonstration of a polyprotein gene product. J Virol (1983) 1.55
Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli. Proc Natl Acad Sci U S A (1984) 1.55
Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli. J Virol (1984) 1.54
Chromosomal assignment of a family of human oncogenes. Proc Natl Acad Sci U S A (1983) 1.53
Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals. Mol Cell Biol (1984) 1.53
Structure and transcription of the cellular homolog (c-myb) of the avian myeloblastosis virus transforming gene (v-myb). J Virol (1983) 1.48
Expression of p21ras in fresh primary and metastatic human colorectal tumors. Proc Natl Acad Sci U S A (1985) 1.47
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46
Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J (1985) 1.46
Localization of c-ras oncogene family on human germ-line chromosomes. Proc Natl Acad Sci U S A (1983) 1.46
Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs. Mol Cell Biol (1984) 1.45
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Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors. Proc Natl Acad Sci U S A (1985) 1.43
Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells. Nucleic Acids Res (1983) 1.41
Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Mol Cell Biol (1985) 1.39
Prediction of the three-dimensional structure of the transforming region of the EJ/T24 human bladder oncogene product and its normal cellular homologue. Proc Natl Acad Sci U S A (1983) 1.37
Co-transfection of normal NIH/3T3 DNA and retroval LTR sequences: a novel strategy for the detection of potential c-onc genes. EMBO J (1984) 1.35
Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol (1985) 1.35
Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein. Mol Cell Biol (1982) 1.34
Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys. Am J Pathol (1993) 1.34
Activation of N-ras in a human melanoma cell line. Mol Cell Biol (1985) 1.30
Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proc Natl Acad Sci U S A (1987) 1.29
Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Mol Cells (2009) 1.28
Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. Proc Natl Acad Sci U S A (1984) 1.23
Expression and characterization of ras mRNAs from Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.21
Isolation and characterization of a stage-specific transforming gene, Tlym-I, from T-cell lymphomas. Proc Natl Acad Sci U S A (1984) 1.20
Activation of a human c-K-ras oncogene. Nucleic Acids Res (1984) 1.19
Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene. Mol Cell Biol (1983) 1.18
Structural organization and expression of human DNA sequences related to the transforming gene of avian myeloblastosis virus. Proc Natl Acad Sci U S A (1983) 1.18
Effects of two major activating lesions on the structure and conformation of human ras oncogene products. Proc Natl Acad Sci U S A (1985) 1.17
Molecularly cloned c-mos(rat) is biologically active. EMBO J (1982) 1.17
Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1983) 1.16
Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells. Proc Natl Acad Sci U S A (1986) 1.16
Immunohistochemical detection of the ras oncogene p21 product in an experimental tumour and in human colorectal neoplasms. Br J Cancer (1985) 1.15
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A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern. J Virol (1985) 1.14
Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene. J Virol (1985) 1.11
KRAS mutation testing in metastatic colorectal cancer. World J Gastroenterol (2012) 1.11
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Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res (1983) 1.10
Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia. Mol Cell Biol (2000) 1.10
Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression. Br J Cancer (1995) 1.09
Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. Proc Natl Acad Sci U S A (1986) 1.09
Molecular cloning and characterization of an activated human c-raf-1 gene. Mol Cell Biol (1987) 1.08
Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Curr Cancer Drug Targets (2010) 1.07
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Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. EMBO J (1984) 1.07
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Molecular cloning of an oncogene from a human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1986) 1.03
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The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol (2006) 1.01
Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers. Proc Natl Acad Sci U S A (1997) 1.01
KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells. Mol Diagn Ther (2013) 1.00
Localization of HeLa cell tumor-suppressor gene to the long arm of chromosome II. Am J Hum Genet (1989) 1.00
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Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene. Proc Natl Acad Sci U S A (1986) 0.98
Bladder cancer cell line cross-contamination: identification using a locus-specific minisatellite probe. Br J Cancer (1988) 0.97
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions. Nucleic Acids Res (1984) 0.96
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Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
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Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature (1981) 17.31
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The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature (1981) 8.44
Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci U S A (1981) 5.51
Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32
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Identification of a normal vertebrate cell protein related to the p21 src of Harvey murine sarcoma virus. Virology (1980) 2.15
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The human minisatellite consensus at breakpoints of oncogene translocations. Nucleic Acids Res (1990) 1.84
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem (1999) 1.82
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Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67
Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. Br J Anaesth (2006) 1.66
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Nausea and vomiting after gynaecological laparoscopy: comparison of premedication with oral ondansetron, metoclopramide and placebo. Br J Anaesth (1994) 1.59
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