PubRank

S J Ashcroft

Author PubWeight™ 111.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 1985 5.52
2 The pentose cycle and insulin release in mouse pancreatic islets. Biochem J 1972 2.79
3 Glucose metabolism in mouse pancreatic islets. Biochem J 1970 2.54
4 Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem J 1973 2.48
5 AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 1998 2.45
6 Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia. Arch Dis Child 1981 2.36
7 The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP. FEBS Lett 1986 2.09
8 Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia 1980 1.90
9 Enzymes of glucose metabolism in normal mouse pancreatic islets. Biochem J 1970 1.73
10 Properties of single potassium channels modulated by glucose in rat pancreatic beta-cells. J Physiol 1988 1.63
11 Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature 1996 1.57
12 Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel. Diabetes 1999 1.44
13 Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of Langerhans. FEBS Lett 1979 1.34
14 Effects of Ca2+, calmodulin and cyclic AMP on the phosphorylation of endogenous proteins by homogenates of rt islets of langerhans. Biochim Biophys Acta 1982 1.30
15 Glucose-6-phosphatase activity of mouse pancreatic islets. Nature 1968 1.24
16 Control of insulin gene expression by glucose. Biochem J 1992 1.23
17 Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53). Diabet Med 2001 1.19
18 The effects of glucose, N-acetylglucosamine, glyceraldehyde and other sugars on insulin release in vivo. Diabetologia 1975 1.17
19 Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40-transformed B cells. FEBS Lett 1987 1.17
20 Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells. Biochem J 1984 1.16
21 Concentration of adenosine 3':5'-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay. Biochem J 1973 1.15
22 The effect of sugars on (pro)insulin biosynthesis. Biochem J 1978 1.15
23 The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells. FEBS Lett 1989 1.14
24 Insulin secretory responses of a clonal cell line of simian virus 40-transformed B cells. Diabetologia 1986 1.13
25 Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel. FEBS Lett 2001 1.10
26 Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans. FEBS Lett 1995 1.09
27 Protein phosphorylation in the pancreatic B-cell. Experientia 1984 1.09
28 Evidence for the participation of calmodulin in stimulus-secretion coupling in the pancreatic beta-cell. Biochem J 1980 1.08
29 Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans. Biochem J 1996 1.08
30 Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1. Diabetes 1998 1.08
31 Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C. Diabetes 1998 1.07
32 Studies on the role of calcium ions in the stimulation by adrenaline of amylase release from rat parotid. Biochem J 1974 1.06
33 Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. J Ethnopharmacol 1998 1.05
34 Regulation and specificity of glucose-stimulated insulin gene expression in human islets of Langerhans. FEBS Lett 1987 1.04
35 Effects of phosphoenolpyruvate, other glycolytic intermediates and methylxanthines on calcium uptake by a mitochondrial fraction from rat pancreatic islets. Diabetologia 1978 1.03
36 Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans. Biochem J 1984 1.03
37 Time course studies of glucose-induced changes in glucose-6-phosphate and fructose-1,6-diphosphate content of mouse and rat pancreatic islets. Diabetologia 1973 1.03
38 ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding. Pflugers Arch 1989 1.03
39 Effects of 2-ketoisocaproate on insulin release and single potassium channel activity in dispersed rat pancreatic beta-cells. J Physiol 1987 1.02
40 The effect of nickel on secretory systems. Studies on the release of amylase, insulin and growth hormone. Biochem J 1974 1.01
41 The control of insulin release by sugars. Ciba Found Symp 1976 1.01
42 Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans. Biochem J 1979 1.00
43 Insulin secretion mechanisms and glucose metabolism in isolated islets. Diabetes 1972 1.00
44 Antidiabetic effects of Tinospora crispa in rats. J Ethnopharmacol 1989 0.99
45 Potentiators of insulin secretion modulate Ca2+ sensitivity in rat pancreatic islets. Mol Cell Endocrinol 1987 0.98
46 Protein kinase activities in rat pancreatic islets of Langerhans. Biochem J 1979 0.96
47 Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus. FEBS Lett 1998 0.95
48 Substrates for cyclic AMP-dependent protein kinase in islets of Langerhans. Studies with forskolin and catalytic subunit. Biochem J 1985 0.95
49 Glucose phosphorylation in mouse pancreatic islets. Biochem J 1968 0.95
50 A truncated isoform of Ca2+/calmodulin-dependent protein kinase II expressed in human islets of Langerhans may result from trans-splicing. FEBS Lett 1997 0.95
51 The hypoglycaemic and insulinotropic activity of Tinospora crispa: studies with human and rat islets and HIT-T15 B cells. Diabetologia 1989 0.94
52 Insulin release from human pancreatic islets in vitro. Diabetologia 1980 0.94
53 Phosphoenolpyruvate in rat pancreatic islets: a possible intracellular trigger of insulin release? Diabetologia 1977 0.92
54 Isolation of human pancreatic islets capable of releasing insulin and metabolising glucose in vitro. Lancet 1971 0.92
55 The effect of N-acylglucosamines on the biosynthesis and secretion of insulin in the rat. Biochem J 1976 0.92
56 Diabetogenic action of alloxan-like compounds: the effect of dehydrouramil hydrate hydrochloride on isolated islets of Langerhans of the rat. Diabetologia 1983 0.91
57 Cyclic nucleotide phosphodiesterase of rat pancreatic islets. Effects of Ca2+, calmodulin and trifluoperazine. Biochem J 1981 0.91
58 Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets. Biochem J 1988 0.90
59 Diabetogenic action of alloxan-like compounds: cytotoxic effects of 5-hydroxy-pseudouric acid and dehydrouramil hydrate hydrochloride on rat pancreatic beta cells. Diabetologia 1984 0.89
60 Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 1998 0.88
61 Effect of adrenal steroids on insulin release from cultured rat islets of Langerhans. Diabetologia 1986 0.87
62 Interactions of the sulfonylurea receptor 1 subunit in the molecular assembly of beta-cell K(ATP) channels. J Biol Chem 2000 0.87
63 Sequence variants of the sarco(endo)plasmic reticulum Ca(2+)-transport ATPase 3 gene (SERCA3) in Caucasian type II diabetic patients (UK Prospective Diabetes Study 48). Diabetologia 1999 0.87
64 The glucose sensor in HIT cells is the glucose transporter. FEBS Lett 1987 0.87
65 Characteristics of the adenohypophyseal Ca2+-phospholipid-dependent protein kinase. Mol Cell Endocrinol 1984 0.85
66 A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines. Biochem J 1996 0.85
67 Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction. FEBS Lett 1990 0.85
68 A novel pancreatic beta-cell isoform of calcium/calmodulin-dependent protein kinase II (beta 3 isoform) contains a proline-rich tandem repeat in the association domain. FEBS Lett 1995 0.85
69 Effect of secretagogues on cytosolic free Ca2+ and insulin release in the hamster clonal beta-cell line HIT-T15. J Mol Endocrinol 1988 0.84
70 Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Mol Cell Endocrinol 1988 0.84
71 Investigation of the molecular assembly of beta-cell K(ATP) channels. FEBS Lett 2000 0.83
72 Superoxide dismutase activity in lymphocytes and polymorphonuclear cells of diabetic patients. Eur J Clin Chem Clin Biochem 1997 0.83
73 The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal beta-cell line, HIT-T15. Biochem J 1990 0.83
74 Effect of secretagogues on cytosolic free Ca2+ and insulin release at different extracellular Ca2+ concentrations in the hamster clonal beta-cell line HIT-T15. Mol Cell Endocrinol 1989 0.83
75 Effects of cholinergic agonists on diacylglycerol and intracellular calcium levels in pancreatic beta-cells. Cell Signal 1993 0.82
76 The beta-cell glibenclamide receptor is an ADP-binding protein. Biochem J 1990 0.82
77 Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15. Biochim Biophys Acta 1991 0.82
78 Effects of phloretin and dextran-linked phloretin on pancreatic islet metabolism and insulin release. Biochim Biophys Acta 1978 0.81
79 Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion. Mol Cell Endocrinol 1996 0.81
80 Structure-activity relationships of alloxan-like compounds derived from uric acid. Br J Pharmacol 1986 0.80
81 Effects of dehydrouramil on protein phosphorylation and insulin secretion in rat islets of Langerhans. Biochem J 1986 0.80
82 N-acetylglucosamine and the substrate-site hypothesis for the control of insulin biosynthesis and secretion. FEBS Lett 1978 0.80
83 Characterisation of endoplasmic reticulum and plasma membrane Ca(2+)-ATPases in pancreatic beta-cells and in islets of Langerhans. Biochim Biophys Acta 1995 0.79
84 Protein carboxymethylation in rat islets of Langerhans. FEBS Lett 1982 0.79
85 Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets. Biochem J 1993 0.79
86 Differential expression of the inwardly-rectifying K-channel ROMK1 in rat brain. Brain Res Mol Brain Res 1994 0.79
87 [Metabolism and insulin secretion in isolated islets]. Acta Diabetol Lat 1969 0.79
88 Detection of islet cell surface antibodies using cloned beta cells and comparison of their incidence with that of islet cell cytoplasmic antibodies. Diabetes Res 1985 0.79
89 A potassium channel modulated by glucose metabolism in rat pancreatic beta-cells. Adv Exp Med Biol 1986 0.78
90 Stimulation of insulin release by vasopressin in the clonal beta-cell line, HIT-T15: the role of protein kinase C. J Mol Endocrinol 1992 0.78
91 Carbohydrate metabolism in pancreatic islets and the release of insulin. Biochem J 1969 0.78
92 Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II. Biochem Biophys Res Commun 1997 0.78
93 [Bioenergetics of islet function: islet glucose metabolism]. Acta Diabetol Lat 1970 0.77
94 Carbohydrate metabolism and the glucoreceptor mechanism. Horm Metab Res Suppl 1980 0.77
95 Mechanisms in the control of insulin release by glucose and other substances. Adv Metab Disord 1970 0.77
96 Human islets of Langerhans express the delta(C) isoform of calcium/calmodulin-dependent protein kinase II. Diabetes Metab Res Rev 1999 0.76
97 Plasma uric acid and total antioxidant status in patients with diabetes mellitus. Horm Metab Res 1997 0.76
98 Structure-function relationships in the beta-cell K(ATP) channel. Biochem Soc Trans 2002 0.76
99 Control of insulin release by glucose. Proc R Soc Med 1968 0.76
100 Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene. Adv Exp Med Biol 1997 0.76
101 Beta-cell recognition of stereoisomers of D-glucose. Diabetologia 1979 0.75
102 Effects of hypophysectomy and growth hormone on cultured islets of Langerhans of the rat. Diabetologia 1982 0.75
103 Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15. FEBS Lett 1988 0.75
104 Effects of growth hormone on insulin release in the rat. Diabetologia 1980 0.75
105 Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15. Biochem J 1991 0.75
106 Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers. Diabetologia 1992 0.75
107 Molecular cloning of the cDNA encoding beta-cell calcium/calmodulin-dependent protein kinase II. Adv Exp Med Biol 1997 0.75
108 Characterization and solubilization of the sulphonylurea receptor in rat brain. Neuropharmacology 1993 0.75
109 Determination of the molecular mass of the native beta-cell sulfonylurea receptor. FEBS Lett 1994 0.75
110 Human insulin promoter driven reporter gene expression. Biochem Soc Trans 1993 0.75
111 The beta-cell ATP-sensitive K(+)-channel: effects of ADP at the sulphonylurea binding site. Biochem Soc Trans 1990 0.75
112 Response to glucose of transcription factor binding to the rat insulin-1 gene promoter. Biochem Biophys Res Commun 1994 0.75
113 Effects of an enkephalin analogue (DAMME) on insulin release from cultured rat islets of Langerhans. Diabetologia 1981 0.75
114 Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell. Adv Exp Med Biol 1997 0.75
115 The beta-cell Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) beta3 isoform containing a proline-rich tandem repeat in the association domain can be found in the human genome. Diabetologia 2001 0.75