Published in Free Radic Res Commun on January 01, 1987
Twofold cost of reproduction: an increase in parental effort leads to higher malarial parasitaemia and to a decrease in resistance to oxidative stress. Proc Biol Sci (2011) 1.29
Phenyl-alpha-tert-butyl nitrone reverses mitochondrial decay in acute Chagas' disease. Am J Pathol (2006) 1.21
TNF-alpha-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-dependent cascade in human airway epithelial cells. Exp Mol Med (2008) 1.02
Enhanced nitrosative stress during Trypanosoma cruzi infection causes nitrotyrosine modification of host proteins: implications in Chagas' disease. Am J Pathol (2008) 0.97
The Alveolate Perkinsus marinus: biological insights from EST gene discovery. BMC Genomics (2010) 0.96
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major. FEBS J (2007) 0.91
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infect Immun (2005) 0.88
Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J (1995) 0.87
What helminth genomes have taught us about parasite evolution. Parasitology (2014) 0.87
Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Tritrichomonas foetus. Histochem Cell Biol (2003) 0.85
Antimalarial efficacy of methylene blue and menadione and their effect on glutathione metabolism of Plasmodium yoelii-infected albino mice. Parasitol Res (2005) 0.84
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl) (2015) 0.82
Oxidative-antioxidant status of Fasciola hepatica-infected rats supplemented with zinc. A mathematical model for zinc bioaccumulation and host growth. Parasitol Res (2008) 0.80
Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasit Vectors (2014) 0.80
Tryparedoxin peroxidase of Leishmania braziliensis: homology modeling and inhibitory effects of flavonoids for anti-leishmanial activity. Bioinformation (2014) 0.78
Clinico-pathological and therapeutic evaluation of Black Bengal goats (Capra hircus) infested with Psoroptes cuniculi mange. J Parasit Dis (2014) 0.75
Plasmodium infection and oxidative status in breeding great tits, Parus major. Malar J (2016) 0.75
Purification and characterization of glutathione reductase (E.C. 1.8.1.7) from bovine filarial worms Setaria cervi. J Parasit Dis (2012) 0.75
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem (2001) 2.79
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol (1999) 2.78
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Mol Microbiol (2000) 2.19
Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet Toxicol (1976) 1.88
Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain. Eur J Biochem (1982) 1.63
Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic-containing pesticide mixture formerly used in vineyards. Int J Cancer (1979) 1.40
Enzymatic reduction studies of nitroheterocycles. Biochem Pharmacol (1999) 1.32
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. Br J Cancer (2001) 1.24
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. Eur J Biochem (1987) 1.21
5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem Toxicol (2000) 1.17
Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts. Cell Biochem Biophys (1998) 1.10
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships. J Med Chem (1999) 1.08
[Trace analysis of N-nitroso compounds. 3. Quantitative thin-layer chromatography of nitrosamines]. J Chromatogr (1970) 1.06
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. J Biol Chem (2001) 1.04
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest. Oncogene (2001) 1.02
Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure (2001) 1.00
Risk characterisation of chemicals in food and diet. Food Chem Toxicol (2003) 0.99
Glutathione reductase from human erythrocytes: amino-acid sequence of the structurally known FAD-binding domain. Eur J Biochem (1981) 0.97
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. Eur J Biochem (1989) 0.96
The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state. Proteins (1994) 0.96
Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes. FEBS Lett (1998) 0.95
3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition. Cancer Res (1993) 0.95
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase. Biochem Pharmacol (1999) 0.95
Nitrate and nitrite in saliva. Oncology (1980) 0.93
Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex. Proteins (1996) 0.89
Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi. Eur J Biochem (1997) 0.89
DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds. J Cancer Res Clin Oncol (1986) 0.89
Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy. Chem Res Toxicol (2000) 0.89
Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme. Eur J Biochem (1998) 0.88
2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi. J Parasitol (2009) 0.88
(2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase. J Med Chem (2000) 0.88
Studies on the stability of trialkyl phosphates and di-(2'deoxythymidine) phosphotriesters in alkaline and neutral solution. A model study for hydrolysis of phosphotriesters in DNA and on the influence of a beta hydroxyethyl ester group. Chem Biol Interact (1986) 0.88
Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors. Bioorg Med Chem (1996) 0.88
Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. Chem Res Toxicol (2001) 0.87
Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi. Eur J Biochem (1990) 0.87
Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe. Food Chem Toxicol (2006) 0.86
Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei. J Biol Chem (2000) 0.86
[A new method for the colorimetric determination of nitrosamines after cleavage of the N-nitroso-group with hydrogen bromide in glacial acetic acid]. Arzneimittelforschung (1970) 0.85
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J Med Chem (1999) 0.85
Automated determination of DNA using the fluorochrome Hoechst 33258. Anal Biochem (1985) 0.84
Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. J Med Chem (1996) 0.84
Mutagenic and cytotoxic effectiveness of zinc dimethyl and zinc diisononyldithiocarbamate in human lymphocyte cultures. Mutat Res (2001) 0.84
Volatile nitrosamines in food. Oncology (1980) 0.84
Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. Br J Cancer (2001) 0.84
Antineoplastic activity of esters and amides of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-aminoacids. J Cancer Res Clin Oncol (1984) 0.84
The influence of N7 substituents on the stability of N7-alkylated guanosines. Chem Biol Interact (1985) 0.84
Contamination of beer with trace quantities of N-nitrosodimethylamine. Food Cosmet Toxicol (1979) 0.83
Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222. J Cancer Res Clin Oncol (1979) 0.83
Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat. Free Radic Res Commun (1991) 0.83
Estimation of human exposure to styrene and ethylbenzene. Toxicology (2000) 0.83
Anticancer activity of new nitrosoureas against Walder carcinosarcoma 256 and DMBA-induced mammary cancer of the rat. Oncology (1980) 0.83
Molecular targets of indirubins. Int J Clin Pharmacol Ther (2005) 0.82
Biological activity of N-nitrosodiethanolamine and of potential metabolites which may arise after activation by alcohol dehydrogenase in Salmonella typhimurium, in mammalian cells, and in vivo. J Cancer Res Clin Oncol (1986) 0.82
Genotoxic effects of the alpha, beta-unsaturated aldehydes 2-trans-butenal, 2-trans-hexenal and 2-trans, 6-cis-nonadienal. Mutat Res (1995) 0.82
Carcinogenic N-nitrosodimethylamine as a contamination in drugs containing 4-dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (amidopyrine, aminophenazone). Arzneimittelforschung (1979) 0.81
Synthesis of novel androgen-linked phosphoramide mustard prodrugs and growth-inhibitory activity in human breast cancer cells. Anticancer Drug Des (1995) 0.81
Alcoholdehydrogenase as an activating enzyme for N-nitrosodiethanolamine (NDELA): in vitro activation of NDELA to a potent mutagen in Salmonella typhimurium. J Cancer Res Clin Oncol (1984) 0.81
Estrogen-linked 2-chloroethylnitrosoureas: anticancer efficacy in MNU-induced rat mammary carcinoma, uterine activity in mice and receptor interactions. Eur J Cancer Clin Oncol (1986) 0.80
Alpha,beta-unsaturated carbonyl compounds: induction of oxidative DNA damage in mammalian cells. Mutagenesis (2003) 0.80
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry (1997) 0.79
Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea. J Natl Cancer Inst (1978) 0.79
A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas. IARC Sci Publ (1987) 0.79
Anticancer efficacy of 2-chloroethylnitrosocarbamoyl derivatives of L-alanine, glycine, their di- and tripeptide homologues and the respective amides in methylnitrosourea-induced rat mammary carcinoma. Br J Cancer (1989) 0.79
Carcinogenicity in rats of high oral doses of N-nitroso-carbaryl, a nitrosated pesticide. Cancer Lett (1976) 0.78
Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells. Mol Biosyst (2012) 0.78
Occurrence of N-nitrosamino acids in cured meat products and their efffect on formation of N-nitrosamines during heating. Food Cosmet Toxicol (1978) 0.78
A method for the determination of N-nitrosoalkanolamines in cosmetics. Z Lebensm Unters Forsch (1988) 0.78
Metabolism of nitrosamines in vivo. V Investigation on 14CO2 exhalation, liver RNA labelling and isolation of two metabolites from urine after administration of [2, 5-14C-]dinitrosopiperazine to rats. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1976) 0.78
Mitochondrial adenylate kinase (AK2) from bovine heart. The complete primary structure. Eur J Biochem (1986) 0.78
Evaluation of new estrogen-linked 2-chloroethylnitrosoureas. I. Short term anticancer efficacy in methylnitrosourea-induced rat mammary carcinoma and hormonal activity in mice. J Cancer Res Clin Oncol (1984) 0.78
New estradiol-linked nitrosoureas: can the pharmacokinetic properties help to explain the pharmacodynamic activities? Eur J Cancer Clin Oncol (1989) 0.78
Glutathione reductase in human and murine lung tumors: high levels of mRNA and enzymatic activity. Cell Mol Biol (Noisy-le-grand) (1993) 0.78
Occurrence of volatile nitrosamines in food: a survey of the West German market. IARC Sci Publ (1980) 0.78
Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. Eur J Biochem (1988) 0.77
Carcinogenicity of N-nitrosoephedrine in rats. Cancer Lett (1978) 0.77
Induction of mitotic gene conversion in Saccharomyces cerevisiae by N-nitrosated pesticides. Mutat Res (1974) 0.77
The level of DNA interstrand crosslinking in bone marrow parallels the extent of myelosuppression in mice treated with four chloroethylnitrosoureas. J Cancer Res Clin Oncol (1984) 0.77
The reaction of nitrite with pesticides. II. Formation, chemical properties and carcinogenic activity of the N-nitroso derivative of N-methyl-1-naphthyl carbamate (carbaryl). Food Cosmet Toxicol (1975) 0.77
Fluoro-substituted N-nitrosamines. 2. Metabolism of N-nitrosodiethylamine and of fluorinated analogs in liver microsomal fractions. Carcinogenesis (1982) 0.77
Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea. Chem Res Toxicol (1992) 0.77
Novel indirubin derivatives, promising anti-tumor agents inhibiting cyclin-dependent kinases. Int J Clin Pharmacol Ther (2004) 0.77
DNA-damaging potential and glutathione depletion of 2-cyclohexene-1-one in mammalian cells, compared to food relevant 2-alkenals. Mutat Res (2001) 0.77
Carcinogenic activity in Sprague-Dawley rats of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-gluco-pyranose (chlorozotocin). Cancer Lett (1979) 0.77
Synthesis and characterization of steroid-linked N-(2-chloroethyl)nitrosoureas. Arch Pharm (Weinheim) (1989) 0.77
Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomized controlled trial. Eur J Nutr (2014) 0.77
Interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies. Eur J Biochem (1984) 0.77
[The reaction of nitrite with pesticides. Formation, chemical properties and carcinogenic activity of the N-nitroso compound of the herbicide N-methyl-N'-(2-benzothiazolyl)-urea (benzthiazuron) (author's transl)]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1974) 0.76
No evidence of carcinogenicity of N-nitrosocimetidine in rats. Hepatogastroenterology (1982) 0.76
Cloning, sequencing and expression of ribonucleotide reductase R2 from Trypanosoma brucei. FEBS Lett (1997) 0.76
FAD analogues as prosthetic groups of human glutathione reductase. Properties of the modified enzyme species and comparisons with the active site structure. Eur J Biochem (1985) 0.76
Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells. Eur J Pharmacol (1995) 0.76
Carcinogenicity of N-nitrosopyrrolidine: dose-response study in rats. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1977) 0.76
Ribonucleotide reductase is regulated via the R2 subunit during the life cycle of Trypanosoma brucei. FEBS Lett (2000) 0.76
Genotoxic effects of 2-trans-hexenal in human buccal mucosa cells in vivo. Mutat Res (1997) 0.76
Risk-benefit considerations of mitigation measures on acrylamide content of foods--a case study on potatoes, cereals and coffee. Br J Nutr (2008) 0.76
Formation of nitrite in gastric juice of patients with various gastric disorders after ingestion of a standard dose of nitrate--a possible risk factor in gastric carcinogenesis. IARC Sci Publ (1984) 0.76