Published in J Med Chem on March 29, 1996
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med (2007) 2.39
Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione. J Biol Chem (2008) 1.02
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents. Curr Pharm Des (2013) 0.83
Characterization of PfTrxR inhibitors using antimalarial assays and in silico techniques. Chem Cent J (2013) 0.77
Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J Biol Chem (1998) 2.72
Substrate positions and induced-fit in crystalline adenylate kinase. J Mol Biol (1977) 2.69
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mol Psychiatry (2009) 2.54
Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Nat Struct Biol (1998) 2.35
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Mol Microbiol (2000) 2.19
Thioredoxin reductase two modes of catalysis have evolved. Eur J Biochem (2000) 1.70
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Mol Psychiatry (2011) 1.65
The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited. J Biol Chem (2000) 1.63
Thioredoxin reductase as a pathophysiological factor and drug target. Eur J Biochem (2000) 1.63
Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain. Eur J Biochem (1982) 1.63
The structure of the flavoenzyme glutathione reductase. Nature (1978) 1.61
Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task. Mol Psychiatry (2010) 1.57
The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli. Proc Natl Acad Sci U S A (1997) 1.56
Synthetic inhibitors of adenylate kinases in the assays for ATPases and phosphokinases. Eur J Biochem (1975) 1.55
Topological comparison of adenyl kinase with other proteins. Nature (1974) 1.45
[Diagnostic benefit of the use of implanted loop recorder (Reveal Plus) for patients with syncope with unclear aetiology]. Vnitr Lek (2007) 1.39
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure (1999) 1.39
The insula is not specifically involved in disgust processing: an fMRI study. Neuroreport (2002) 1.38
Three-dimensional structure of glutathione reductase at 2 A resolution. J Mol Biol (1981) 1.32
Enzymatic reduction studies of nitroheterocycles. Biochem Pharmacol (1999) 1.32
A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase. Biochem J (1998) 1.23
The thioredoxin system of Plasmodium falciparum and other parasites. Cell Mol Life Sci (2002) 1.22
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. Eur J Biochem (1987) 1.21
Structural relationships in the adenylate kinase family. Eur J Biochem (1986) 1.18
[The particularities of contractile proteins of the arteries]. Biochem Z (1965) 1.18
FAD-binding site of glutathione reductase. J Mol Biol (1982) 1.18
Folding of the four domains and dimerization are impaired by the Gly446-->Glu exchange in human glutathione reductase. Implications for the design of antiparasitic drugs. Biochemistry (1993) 1.13
The enzymatic synthesis of thiophosphate analogs of nucleotides. Biochim Biophys Acta (1972) 1.11
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships. J Med Chem (1999) 1.08
Fluorescent and spin label probes of the environments of the sulfhydryl groups of porcine muscle adenylate kinase. J Biol Chem (1975) 1.07
Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett (1998) 1.07
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. J Mol Biol (2003) 1.05
Oxidative stress as a defense mechanism against parasitic infections. Free Radic Res Commun (1987) 1.04
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. J Biol Chem (2001) 1.04
The CACNA1C risk variant for bipolar disorder influences limbic activity. Mol Psychiatry (2010) 1.01
Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS). J Neural Transm (Vienna) (2005) 0.99
Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria. Eur J Biochem (1996) 0.99
Cloning and sequencing of mammalian glutathione reductase cDNA. Eur J Biochem (1990) 0.98
Glutathione reductase from human erythrocytes: amino-acid sequence of the structurally known FAD-binding domain. Eur J Biochem (1981) 0.97
Redox processes in malaria and other parasitic diseases. Determination of intracellular glutathione. Histochemistry (1994) 0.97
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. Eur J Biochem (1989) 0.96
The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state. Proteins (1994) 0.96
Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes. FEBS Lett (1998) 0.95
Personality and emotion: test of Gray's personality theory by means of an fMRI study. Behav Neurosci (2004) 0.95
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase. Biochem Pharmacol (1999) 0.95
Objective measurement of motor activity during cognitive performance in adults with attention-deficit/hyperactivity disorder. Acta Psychiatr Scand (2010) 0.95
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J Med Chem (2001) 0.94
Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex. J Mol Biol (2000) 0.94
Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7. Mol Biochem Parasitol (2000) 0.94
Glutathione reductase-deficient erythrocytes as host cells of malarial parasites. Biochem Pharmacol (1988) 0.94
Glutathione reductase inhibitors as potential antimalarial drugs. Effects of nitrosoureas on Plasmodium falciparum in vitro. Biochem Pharmacol (1988) 0.94
Glutathione reductase from human erythrocytes. Isolation of the enzyme and sequence analysis of the redox-active peptide. Eur J Biochem (1977) 0.92
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue. Redox Rep (2011) 0.91
ADHD related behaviors are associated with brain activation in the reward system. Neuropsychologia (2010) 0.91
Recombinant putative glutathione reductase of Plasmodium falciparum exhibits thioredoxin reductase activity. Mol Biochem Parasitol (1996) 0.90
Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy. J Med Chem (2001) 0.90
Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex. Proteins (1996) 0.89
Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi. Eur J Biochem (1997) 0.89
Inhibition of human glutathione reductase by S-nitrosoglutathione. Eur J Biochem (1995) 0.89
Role of active site tyrosine residues in catalysis by human glutathione reductase. Biochemistry (1998) 0.89
Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme. Eur J Biochem (1998) 0.88
2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi. J Parasitol (2009) 0.88
Primary and tertiary structure of the principal human adenylate kinase. Eur J Biochem (1976) 0.88
(2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase. J Med Chem (2000) 0.88
Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors. Bioorg Med Chem (1996) 0.88
Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi. Eur J Biochem (1990) 0.87
A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: a genetic imaging study. Biol Psychol (2008) 0.86
Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei. J Biol Chem (2000) 0.86
Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study. Redox Rep (2005) 0.85
Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase. Biochem Pharmacol (1997) 0.85
The structural isomerisation of human-muscle adenylate kinase as studied by 1H-nuclear magnetic resonance. Eur J Biochem (1982) 0.85
Latent inhibition and schizophrenia: Pavlovian conditioning of autonomic responses. Schizophr Res (2002) 0.85
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. J Biol Chem (2000) 0.85
Generating compatible translation initiation regions for heterologous gene expression in Escherichia coli by exhaustive periShine-Dalgarno mutagenesis. Human glutathione reductase cDNA as a model. Nucleic Acids Res (1992) 0.85
Neuronal correlates of affective theory of mind in schizophrenia out-patients: evidence for a baseline deficit. Psychol Med (2010) 0.85
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J Med Chem (1999) 0.85
1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems. Methods Enzymol (1995) 0.85
Mitochondrial adenylate kinase (AK2) from bovine heart. Homology with the cytosolic isoenzyme in the catalytic region. Eur J Biochem (1984) 0.84
The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase. FEBS Lett (1997) 0.84
Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors. Eur J Biochem (1997) 0.84
Flavin analogs with antimalarial activity as glutathione reductase inhibitors. Biochem Pharmacol (1990) 0.83
Differential activation of pre-SMA and SMA proper during action observation: effects of instructions. Neuroimage (2005) 0.83
Halothane binds in the adenine-specific niche of crystalline adenylate kinase. FEBS Lett (1977) 0.82
NADPH-dependent disulphide reductases. Biochem Soc Trans (1989) 0.82
Orientation of colonized sand flies Phlebotomus papatasi, P. duboscqi, and Lutzomyia longipalpis (Diptera: Psychodidae) to diverse honeys using a 3-chamber in-line olfactometer. J Vector Ecol (2014) 0.81
Sensitivity of adenylate kinase isozymes from normal and dystrophic human muscle to sulfhydryl reagents. Biochim Biophys Acta (1972) 0.81
Multi-site reproducibility of prefrontal-hippocampal connectivity estimates by stochastic DCM. Neuroimage (2013) 0.80
Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. Free Radic Biol Med (1995) 0.80
Patterns of recovery of autonomic dysfunctions and neurocognitive deficits in schizophrenics after acute psychotic episodes. J Abnorm Psychol (2001) 0.80
A glutathione reductase-like flavoenzyme of the malaria parasite Plasmodium falciparum: structural considerations based on the DNA sequence. Biochem Soc Trans (1996) 0.80
Mitochondrial GTP-AMP phosphotransferase. 1. Purification and properties. Eur J Biochem (1979) 0.80
Muscle adenylate kinase in Duchenne muscular dystrophy. Biochim Biophys Acta (1986) 0.79
A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas. IARC Sci Publ (1987) 0.79
The C-terminal fragment of human glutathione reductase contains the postulated catalytic histidine. FEBS Lett (1979) 0.79