Published in Diabetes on March 01, 1986
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest (1987) 2.96
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest (1992) 1.95
Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. PLoS Med (2008) 1.10
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J Clin Invest (1995) 1.08
Biphasic insulin secretion from freshly isolated or cultured, perifused rodent islets: comparative studies with rats and mice. Metabolism (2008) 0.99
Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice. Endocrinology (2014) 0.83
The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act. Curr Diabetes Rev (2012) 0.80
Interactions between lithium, inositol and mono-oleoylglycerol in the regulation of insulin secretion from isolated perifused rat islets. Biochem J (1989) 0.79
A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex. J Physiol (2003) 0.77
Therapeutic dilemmas in type II diabetes mellitus--improving and maintaining beta-cell and insulin sensitivity. West J Med (1988) 0.75
Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology (1968) 3.23
Vitamin D deficiency inhibits pancreatic secretion of insulin. Science (1980) 3.00
Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest (1984) 2.52
Cation requirements for insulin secretion in the isolated perfused pancreas. Diabetes (1966) 2.21
A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest (1972) 2.20
The response of human leucocyte cultures to stimulation by tuberculin and phytohaemagglutinin measured by the uptake of radioactive thymidine. Clin Exp Immunol (1967) 2.01
Requirement for calcium ion in insulin secretion by the perfused rat pancreas. Am J Physiol (1968) 1.82
The in vitro perfused pancreas. Methods Enzymol (1975) 1.56
Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest (1974) 1.55
Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium. J Biol Chem (1975) 1.50
Effect of selected hexoses, of epinephrine and of glucagon on insulin secretion in man. Diabetes (1966) 1.48
Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release. Science (1973) 1.43
Immunologic studies of adrenocorticotropic hormone (ACTH): dissociation of biologic and immunologic activities. J Clin Endocrinol Metab (1965) 1.38
Changes in carbohydrate substrates, amino acids and ammonia in the brain during insulin-induced hypoglycemia. J Neurochem (1974) 1.33
Insulinopenic diabetes after rodenticide (Vacor) ingestion: a unique model of acquired diabetes in man. Diabetes (1980) 1.29
Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure. Antimicrob Agents Chemother (1992) 1.29
Visualization of intravenously administered contrast material in the CSF on fluid-attenuated inversion-recovery MR images: an in vitro and animal-model investigation. AJNR Am J Neuroradiol (2000) 1.23
Regulation of pancreatic insulin and glucagon secretion. Annu Rev Physiol (1976) 1.23
Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and to EEG. J Neurochem (1974) 1.21
Clinical pharmacology--providing tools and expertise for translational medicine. Br J Clin Pharmacol (2008) 1.19
Clinical pharmacology: a declaration of intent. Br J Clin Pharmacol (2010) 1.18
Stimulation of insulin release by glucagon in noninsulin-dependent diabetics. Metabolism (1966) 1.17
An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin Pharmacol Ther (2010) 1.15
A threshold distribution hypothesis for packet storage of insulin. II. Effect of calcium. Diabetes (1972) 1.14
Phase I study of twice-weekly gemcitabine and concomitant external-beam radiotherapy in patients with adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys (2001) 1.12
Pancreatic action of the sulfonylureas. Fed Proc (1977) 1.11
The relationship of obesity and growth hormone to serum insulin levels. Ann N Y Acad Sci (1965) 1.09
Insulin and the pancreas. Annu Rev Physiol (1966) 1.08
[Further studies on the dynamic aspects of insulin release in vitro with evidence for a two-compartmental storage system]. Acta Diabetol Lat (1969) 1.08
Noradrenergic modulation of cognitive flexibility in problem solving. Neuroreport (1999) 1.06
Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol and theophylline: evidence for a preferential effect on glucagon secretion. Endocrinology (1975) 1.06
Dynamic synthesis and release of insulin and proinsulin from perifused islets. Diabetes (1973) 1.05
Early phase of insulin release. Diabetes (1968) 1.04
Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin. Science (1982) 1.02
Psychosis in a child inhaling budesonide. Lancet (1983) 1.00
Water and electrolyte losses in neonatal calves with acute diarrhea. A complete balance study. Cornell Vet (1972) 1.00
Relationships between arginine and glucose in the induction of insulin secretion from the isolated, perfused rat pancreas. Endocrinology (1972) 0.99
The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat Biotechnol (1997) 0.99
Diabetes mellitus in rabbits immunized with insulin. Diabetes (1966) 0.98
A study of the effects of sumatriptan on myocardial perfusion in healthy female migraineurs using 13NH3 positron emission tomography. Neurology (1997) 0.98
Effect of pulse administration of glucose or glucagon on insulin secretion in vitro. Metabolism (1967) 0.95
Insulin and the pancreas. Vitam Horm (1970) 0.95
Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster. J Clin Invest (1974) 0.95
Mechanisms activating glycolysis in the brain in arterial hypoxia. J Neurochem (1974) 0.95
Glucose-stimulated 45Calcium efflux from isolated rat pancreatic islets. J Clin Invest (1978) 0.94
[Factors influencing different rates of insulin release in vitro]. Acta Diabetol Lat (1968) 0.94
Experimental immune diabetes in the rabbit. Light, fluorescence, and electron microscopic studies. Am J Pathol (1969) 0.94
Characteristics of desensitization of insulin secretion in fully in vitro systems. Endocrinology (1988) 0.94
Changes in plasma glucose and lactate concentrations and enzyme activities in the neonatal calf with diarrhea. Am J Vet Res (1975) 0.93
Prevention of insulin aggregation by dicarboxylic amino acids during prolonged infusion. Diabetes (1981) 0.93
Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells. Diabetes (1984) 0.92
Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion. Endocrinology (1994) 0.92
Accumulation of midazolam after repeated dosage in patients receiving mechanical ventilation in an intensive care unit. Br Med J (Clin Res Ed) (1984) 0.92
Cyclic nucleotides in pancreatic islets. Tolbutamide- and arginine-induced insulin release. Diabetes (1976) 0.92
Comparison of storage- and signal-limited models of pancreatic insulin secretion. Am J Physiol (1980) 0.92
Concomitant Creutzfeldt-Jakob and Alzheimer diseases. Acta Neuropathol (1991) 0.91
Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor? Science (1974) 0.91
Evaluation of ammonium chloride as a urinary acidifier in the cat. J Am Vet Med Assoc (1984) 0.90
Drug-drug interactions: is there an optimal way to study them? Br J Clin Pharmacol (2010) 0.90
Urinary acidification in the prevention and treatment of feline struvite urolithiasis. J Am Vet Med Assoc (1984) 0.90
Measurement of immune complexes in insulin-treated diabetics. J Immunol Methods (1973) 0.90
Effects of dietary fiber supplementation on glycemic control in dogs with alloxan-induced diabetes mellitus. Am J Vet Res (1991) 0.90
Testicular regulation in nonmammalian vertebrates. Biol Reprod (1978) 0.89
Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu. J Clin Oncol (1995) 0.89
Heterogeneity and compartmental properties of insulin storage and secretion in rat islets. J Clin Invest (1982) 0.88
Enhancement of arginine-induced insulin secretion in man by prior administration of glucose. Diabetes (1971) 0.88
Arterial acid-base changes in unanaesthetized rats in acute hypoxia. Respir Physiol (1973) 0.88
Looking back: editors' pick of 2008. Br J Clin Pharmacol (2009) 0.87
Effect of perfusion rate on absorption, surface area, unstirred water layer thickness, permeability, and intraluminal pressure in the rat ileum in vivo. Gastroenterology (1975) 0.87
Interaction of calcium and glucose on glucagon secretion. Endocrinology (1976) 0.87
Effect of age of rat on development of hepatic carriers for bilirubin: a possible explanation for physiologic jaundice and hyperbilirubinemia in the newborn. Metabolism (1970) 0.86
Pathophysiologic changes due to coronavirus-induced diarrhea in the calf. J Am Vet Med Assoc (1978) 0.86
"Staircase" glucose stimulation of insulin secretion in obesity. Measure of beta-cell sensitivity and capacity. Diabetes (1974) 0.86
Desensitization of the insulin-secreting beta cell. J Cell Biochem (1992) 0.85
The histopathology of immune diabetes in the rabbit. Am J Pathol (1968) 0.85
Effect of dietary calcium, magnesium, and phosphorus on phosphate urolithiasis in rats. Invest Urol (1980) 0.84
Progressive damage of cultured pancreatic islets after single early exposure to streptozocin. Diabetes (1986) 0.84
Differences in insulin secretion between the rat and mouse: role of cAMP. Eur J Endocrinol (1995) 0.84
Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets. Diabetes (1990) 0.84
Metabolic and underlying causes of diabetes mellitus. Diabetes (1982) 0.84
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity. Leukemia (2007) 0.84
Ultrastructure of beta-cells during the dynamic response to glucose and tolbutamide in vitro. Diabetologia (1970) 0.84
[Regulation of insulin release in perifused pancreatic tissue]. Acta Diabetol Lat (1969) 0.83
Insulin biosynthesis in HIT cells. Effects of glucose, forskolin, IBMX, and dexamethasone. Diabetes (1988) 0.83
Systemic steroids in chronic severe asthma. Br Med J (Clin Res Ed) (1986) 0.83
Calcium affects insulin release and membrane potential in islet beta-cells. Am J Physiol (1981) 0.83
Human gastrointestinal absorption of acyclovir from tablet duodenal infusion and sipped solution. Br J Clin Pharmacol (1986) 0.83
Kinetics of 65zinc uptake and distribution in fractions from cultured rat islets of langerhans. Diabetes (1980) 0.83
Inhibition of insulin secretion by diphenylhydantoin in the isolated perfused pancreas. J Clin Endocrinol Metab (1970) 0.83
Direct effects of glucose on proinsulin synthesis and processing during desensitization. Endocrinology (1987) 0.83
Evaluation of the role of exogenous insulin on phasic insulin secretion. Diabetes (1973) 0.82
Calcium-magnesium antagonism in insulin secretion by the perfused rat pancreas. Endocrinology (1969) 0.82
Kinetic aspects of compartmental storage and secretion of insulin and zinc. Experientia (1984) 0.82
Calcium dependency of glucagon secretion from the in vitro perfused rat pancreas. Endocrinology (1974) 0.82
Relationship between insulin release and 65zinc efflux from rat pancreatic islets maintained in tissue culture. Diabetes (1984) 0.82