Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.

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🔗 View Article (PMID 35177862)

Published in Nat Med on February 17, 2022

Authors

K A Sacco¹, Riccardo Castagnoli²^,3, Svetlana Vakkilainen², Can Liu⁴^,5, Ottavia M Delmonte², Cihan Oguz⁶^,7, Ian M Kaplan⁸, Sara Alehashemi², Peter D Burbelo⁹, Farzana Bhuyan², Adriana A de Jesus², Kerry Dobbs¹⁰, Lindsey B Rosen², Aristine Cheng², Elana Shaw², Mikko S Vakkilainen¹¹, Francesca Pala², Justin Lack⁴^,6, Yu Zhang², Danielle L Fink¹², Vasileios Oikonomou², Andrew L Snow¹³, Clifton L Dalgard¹⁴^,15, Jinguo Chen¹⁶, Brian A Sellers¹⁶, Gina A Montealegre Sanchez¹⁷, Karyl Barron¹⁸, Emma Rey-Jurado¹⁹, Cecilia Vial¹⁹, Maria Cecilia Poli¹⁹^,20, Amelia Licari³, Daniela Montagna³^,21, Gian Luigi Marseglia³, Francesco Licciardi²², Ugo Ramenghi²², Valentina Discepolo²³, Andrea Lo Vecchio²³, Alfredo Guarino²³, Eli M Eisenstein²⁴, Luisa Imberti²⁵, Alessandra Sottini²⁵, Andrea Biondi²⁶, Sayonara Mató²⁷, Dana Gerstbacher²⁸, Meng Truong², Michael A Stack², Mary Magliocco²⁹, Marita Bosticardo², Tomoki Kawai², Jeffrey J Danielson², Tyler Hulett³⁰, Manor Askenazi³⁰, Shaohui Hu³⁰, NIAID Immune Response to COVID Group, Chile MIS-C Group, Pavia Pediatric COVID-19 Group, Jeffrey I Cohen³¹, Helen C Su³², Douglas B Kuhns¹², Michail S Lionakis², Thomas M Snyder⁸, Steven M Holland³³^,34, Raphaela Goldbach-Mansky², John S Tsang⁴^,35, Luigi D Notarangelo³⁶

Author Affiliations

1: Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
2: Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
3: Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
4: Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
5: Graduate Program in Biological Sciences, University of Maryland, College Park, MD, USA.
6: NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
7: Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA.
8: Adaptive Biotechnologies, Seattle, WA, USA.
9: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
10: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892.
11: Department of Computer Science, Aalto University, Helsinki, Finland.
12: Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
13: Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and andrew.snow@usuhs.edu.
14: Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
15: The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
16: Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA.
17: Intramural Clinical Management and Operation Branch (ICMOB), Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
18: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
19: Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
20: Unidad de Inmunología y Reumatología, Hospital de niños Dr. Roberto del Río, Santiago, Chile.
21: Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
22: Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.
23: Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy.
24: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.
25: CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
26: Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.
27: Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA.
28: Division of Pediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, USA.
29: Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
30: CDI Laboratories, Antygen Division, Baltimore, MD, USA.
31: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
32: Clinical Genomics Program, Human Immunological Diseases Section, Laboratory of Host Defenses, and.
33: National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institutes of Health, Bethesda, MD 20892.
34: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.
35: NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
36: Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Boston, MA.