Published in J Exp Med on June 12, 2017
Severe viral respiratory infections in children with IFIH1 loss-of-function mutations. Proc Natl Acad Sci U S A (2017) 0.76
Recurrent and Prolonged Infections in a Child with a Homozygous IFIH1 Nonsense Mutation. Front Genet (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins (2006) 22.80
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Clinical whole-exome sequencing for the diagnosis of mendelian disorders. N Engl J Med (2013) 15.85
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Molecular findings among patients referred for clinical whole-exome sequencing. JAMA (2014) 6.46
The common cold. Lancet (2003) 5.86
Runs of homozygosity in European populations. Am J Hum Genet (2008) 5.34
Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med (2015) 4.90
Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science (2009) 3.94
Viruses and bacteria in the etiology of the common cold. J Clin Microbiol (1998) 3.24
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald. J Chem Theory Comput (2013) 3.08
Community Surveillance of Respiratory Viruses Among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study. Clin Infect Dis (2015) 3.03
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol (2000) 3.00
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet (2014) 2.88
Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol (2011) 2.85
Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol (2009) 2.37
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell (2012) 2.34
Development of polyphosphate parameters for use with the AMBER force field. J Comput Chem (2003) 2.33
Identification of a large set of rare complete human knockouts. Nat Genet (2015) 2.28
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog (2009) 2.24
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system. Blood (2004) 1.99
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog (2010) 1.82
Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis (2011) 1.78
Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol (2009) 1.77
Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J Immunol (2006) 1.69
MDA-5 recognition of a murine norovirus. PLoS Pathog (2008) 1.68
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog (2010) 1.66
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency. Science (2015) 1.58
A serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell (2015) 1.57
Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia. J Virol (2008) 1.54
Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A (2012) 1.46
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection. J Virol (2013) 1.42
Clinical application of whole-exome sequencing across clinical indications. Genet Med (2015) 1.41
Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell (2017) 1.41
Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies. J Exp Med (2014) 1.41
Aicardi-Goutières syndrome is caused by IFIH1 mutations. Am J Hum Genet (2014) 1.41
MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PLoS Pathog (2011) 1.31
Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus. J Immunol (2007) 1.29
MDA5 and MAVS mediate type I interferon responses to coxsackie B virus. J Virol (2010) 1.28
Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. J Virol (2008) 1.22
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes Infect (2006) 1.22
Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol (2014) 1.20
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol (2014) 1.19
Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. Am J Hum Genet (2016) 1.18
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. Am J Hum Genet (2015) 1.17
Rational Design of Particle Mesh Ewald Compatible Lennard-Jones Parameters for +2 Metal Cations in Explicit Solvent. J Chem Theory Comput (2013) 1.16
Infectious pathogens and bronchiolitis outcomes. Expert Rev Anti Infect Ther (2014) 1.15
Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model. J Clin Virol (2011) 1.09
Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5. J Virol (2010) 1.07
Improved molecular typing assay for rhinovirus species A, B, and C. J Clin Microbiol (2014) 1.05
RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. J Clin Invest (2011) 1.04
Update on rhinovirus and coronavirus infections. Semin Respir Crit Care Med (2011) 1.01
The mutation significance cutoff: gene-level thresholds for variant predictions. Nat Methods (2016) 1.01
Enteroviruses and type 1 diabetes: towards a better understanding of the relationship. Rev Med Virol (2010) 0.99
Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response. Virulence (2011) 0.98
Calcium phosphate transfection. Curr Protoc Cell Biol (2003) 0.97
Melanoma differentiation-associated gene 5 is critical for protection against Theiler's virus-induced demyelinating disease. J Virol (2011) 0.96
Influenza: propagation, quantification, and storage. Curr Protoc Microbiol (2013) 0.93
TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. Am J Hum Genet (2013) 0.93
Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo. J Virol (2012) 0.91
Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency. Arthritis Rheumatol (2015) 0.91
High level transient gene expression in human lymphoid cells by SV40 large T antigen boost. Nucleic Acids Res (1992) 0.90
SnIPRE: selection inference using a Poisson random effects model. PLoS Comput Biol (2012) 0.90
Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview. J Exp Med (2016) 0.86
In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus. Cell Rep (2015) 0.85
Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation. Am J Respir Crit Care Med (2014) 0.81
Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome. Am J Respir Cell Mol Biol (2016) 0.80
Enterovirus infection and type 1 diabetes: closing in on a link? Diabetes (2015) 0.80
Growth of human rhinovirus in H1-HeLa cell suspension culture and purification of virions. Methods Mol Biol (2015) 0.79
Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5. J Innate Immun (2014) 0.79
Molecular identification and quantification of human rhinoviruses in respiratory samples. Methods Mol Biol (2015) 0.77
Enterovirus antibody titers after IVIG replacement in agammaglobulinemic children. Clin Microbiol Infect (2000) 0.76
Enterovirus-specific IgG in intravenous immunoglobulin preparations. Ann Allergy Asthma Immunol (2011) 0.76
Infectivity assays of human rhinovirus-A and -B serotypes. Methods Mol Biol (2015) 0.75
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency. Blood (2016) 0.83
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J Exp Med (2016) 0.78
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med (2016) 0.78
ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans. J Exp Med (2017) 0.75
Self-reactive VH4-34-expressing IgG B cells recognize commensal bacteria. J Exp Med (2017) 0.75
Effect of Concomitant Azithromycin and Tobramycin Use on Cystic Fibrosis Pulmonary Exacerbation Treatment. Ann Am Thorac Soc (2020) 0.75
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nat Med (2022) 0.75