Published in Anesth Analg on June 01, 1987
An evaluation of 10 percent and 20 percent benzocaine gels in patients with acute toothaches: efficacy, tolerability and compliance with label dose administration directions. J Am Dent Assoc (2013) 1.57
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Steroids: pharmacology, complications, and practice delivery issues. Ochsner J (2014) 0.85
Cervical spinal cord injection of epidural corticosteroids: comprehensive longitudinal study including multiparametric magnetic resonance imaging. Pain (2012) 0.85
Comparative evaluation of ropivacaine and ropivacaine with dexamethasone in supraclavicular brachial plexus block for postoperative analgesia. Anesth Essays Res (2015) 0.83
The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol (1973) 6.49
Molecular mechanisms of local anesthesia: a review. Anesthesiology (1990) 2.82
Clinical experience with the peribulbar block for ophthalmologic surgery. Reg Anesth (1993) 2.46
The binding of labelled saxitoxin to the sodium channels in nerve membranes. J Physiol (1973) 2.10
Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane. Proc Natl Acad Sci U S A (1974) 2.06
Statistical methods in anesthesia articles: an evaluation of two American journals during two six-month periods. Anesth Analg (1985) 2.01
A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. J Physiol (1976) 1.86
Analgesic responses to i.v. lignocaine. Br J Anaesth (1982) 1.81
Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain. J Membr Biol (1979) 1.79
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol (1993) 1.77
Plasma concentrations of local anaesthetics after interscalene brachial plexus block. Br J Anaesth (1977) 1.66
Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Proc Natl Acad Sci U S A (1986) 1.59
Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology (1995) 1.57
Twitch, tetanus and posttetanic potentiation as indices of nerve-muscle block in man. Anesthesiology (1969) 1.55
The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesth Analg (1993) 1.47
On the voltage-dependent action of tetrodotoxin. Biophys J (1977) 1.47
Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. J Gen Physiol (1987) 1.42
Epidural steroid injections: update on efficacy, safety, and newer medications for injection. Minerva Anestesiol (2014) 1.40
Epidural steroid injections for low back pain and lumbosacral radiculopathy. Pain (1986) 1.31
Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Mol Pharmacol (1999) 1.31
Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. J Neurosci (2001) 1.30
Saxitoxin binding to sodium channels of rat skeletal muscles. J Physiol (1980) 1.29
A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology (1998) 1.21
Activation and inactivation of postjunctional membrane receptors. Ann N Y Acad Sci (1966) 1.20
Effects of fentanyl and sufentanil on peripheral mammalian nerves. Anesth Analg (1987) 1.20
Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesth Analg (1989) 1.16
Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosens Mot Res (1994) 1.15
The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment. Anesth Analg (2001) 1.15
Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology (1994) 1.14
Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology (1990) 1.12
The mechanisms underlying neuromuscular block following prolonged exposure to depolarizing agents. Ann N Y Acad Sci (1966) 1.09
Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster. Nature (1984) 1.08
Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus. Mol Pharmacol (1983) 1.08
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J (1990) 1.07
Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clin Pharmacol Ther (1989) 1.05
Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve. Anesthesiology (2001) 1.03
Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Anesth Analg (1988) 1.03
Effects of the dipolar form of phloretin on potassium conductance in squid giant axons. Biophys J (1980) 1.02
Dependence of lidocaine potency on pH and PCO2. Anesth Analg (1987) 1.02
Block of human heart hH1 sodium channels by the enantiomers of bupivacaine. Anesthesiology (2000) 1.01
Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature. Anesth Analg (1987) 1.01
Sodium channels in axons and glial cells of the optic nerve of Necturus maculosa. J Gen Physiol (1979) 1.00
Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat. Pain (1999) 0.99
Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Res (1990) 0.99
Effects of etomidate on hormonal responses to surgical stress. Anesthesiology (1984) 0.99
Pharmacology of local anesthetic agents. J Dent Res (1981) 0.98
Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves. J Gen Physiol (1986) 0.98
Pulsed radiofrequency: a critical review of its efficacy. Anaesth Intensive Care (2007) 0.98
A new local anesthetic, ropivacaine. Its epidural effects in humans. Anesth Analg (1990) 0.98
Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus. Toxicon (1991) 0.97
Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster. Biochim Biophys Acta (1980) 0.95
Esmolol for control of increases in heart rate and blood pressure during tracheal intubation after thiopentone and succinylcholine. Can Anaesth Soc J (1986) 0.94
Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue. J Gen Physiol (1989) 0.94
Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog. Anesth Analg (1988) 0.94
Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission. Br J Pharmacol (1994) 0.94
Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart. Reg Anesth (1992) 0.94
Tachykinin antagonists have potent local anaesthetic actions. Eur J Pharmacol (1985) 0.94
Differential sensitivities of mammalian nerve fibers to local anesthetic agents. Anesthesiology (1980) 0.93
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med (2000) 0.93
Bupivacaine for intercostal nerve blocks in children: blood concentrations and pharmacokinetics. Anesth Analg (1986) 0.93
Ketamine treatment of penile erection in the operating room. Anesth Analg (1983) 0.92
Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res (2000) 0.92
The role of length of nerve exposed to local anesthetics in impulse blocking action. Anesth Analg (1989) 0.92
Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesth Analg (1983) 0.90
Components of the plasma membrane of growing axons. III. Saxitoxin binding to sodium channels. J Cell Biol (1984) 0.90
The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve. J Physiol (1975) 0.90
Binding of radioactively labeled saxitoxin to the squid giant axon. J Membr Biol (1979) 0.90
Pharmacology of local anaesthetic agents. Br J Anaesth (1986) 0.90
Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. Anesth Analg (1991) 0.89
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve. Anesthesiology (1994) 0.89
Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve. J Pharmacol Exp Ther (1997) 0.89
Systemic toxicity of local anesthetic agents. Anesth Analg (1978) 0.89
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels. Mol Pharmacol (1986) 0.89
Plasma lignocaine concentrations following endotracheal spraying with an aerosol. Br J Anaesth (1976) 0.88
New oral anticoagulants and regional anaesthesia. Br J Anaesth (2013) 0.88
What determines anesthetic induction dose? It's the front-end kinetics, doctor! Anesth Analg (1999) 0.88
Saxitoxin blocks batrachotoxin-modified sodium channels in the node of Ranvier in a voltage-dependent manner. Biophys J (1986) 0.88
Acute cardiovascular toxicity of intravenous amide local anesthetics in anesthetized ventilated dogs. Anesth Analg (1982) 0.88
Local anaesthetic drugs--an historical perspective. Br J Anaesth (1984) 0.88
Effect of baricity on spinal anaesthesia with amethocaine. Br J Anaesth (1980) 0.88
Determination of ketorolac in human plasma by reversed-phase high-performance liquid chromatography using solid-phase extraction and ultraviolet detection. J Chromatogr B Biomed Sci Appl (2001) 0.87
Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus. J Neurosci (1985) 0.87
Clinical pharmacology of N,N-bis(phenylcarbamolymethyl)dimethylammonium chloride (QX-572), a new antiarrhythmic agent. J Clin Pharmacol J New Drugs (1968) 0.87
Systemic toxicity of ropivacaine during ovine pregnancy. Anesthesiology (1991) 0.87
Comparative clinical pharmacology of local anesthetic agents. Anesthesiology (1971) 0.87
Local anesthetics. Handb Exp Pharmacol (2007) 0.87
Comparison of bupivacaine- and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg (1989) 0.87
Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology (1994) 0.86
Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents. Clin Pharmacol Ther (2008) 0.86
Midazolam versus hydroxyzine as intramuscular premedicant. Can Anaesth Soc J (1983) 0.85
Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in the rat. Anesthesiology (2000) 0.85
Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology (1999) 0.85
Determinants of etidocaine concentration in the blood. Anesthesiology (1975) 0.85
Vasoconstrictors in spinal anesthesia with tetracaine--a comparison of epinephrine and phenylephrine. Anesth Analg (1984) 0.85
A comparison of the stimulatory effects of cadmium and zinc on normal and lead-inhibited human erythrocytic delta-aminolevulinic acid dehydratase activity in vitro. Toxicol Appl Pharmacol (1978) 0.85
Local anesthetics inhibit the G protein-mediated modulation of K+ and Ca++ currents in anterior pituitary cells. Mol Pharmacol (1999) 0.84
Local anesthesia. 1. N Engl J Med (1972) 0.84
Bupivacaine toxicity in pregnant and nonpregnant ewes. Anesthesiology (1985) 0.84
Local anesthetics inhibit substance P binding and evoked increases in intracellular Ca2+. Anesthesiology (1995) 0.84