Published in J Membr Biol on August 01, 1979
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A seven-year field trial of two typhoid vaccines in Guyana. Lancet (1967) 2.20
The binding of labelled saxitoxin to the sodium channels in nerve membranes. J Physiol (1973) 2.10
Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane. Proc Natl Acad Sci U S A (1974) 2.06
Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres. J Physiol (1981) 2.01
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The oxygen consumption of mammalian non-myelinated nerve fibres at rest and during activity. J Physiol (1967) 1.93
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A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. J Physiol (1976) 1.86
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Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain. J Membr Biol (1979) 1.79
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol (1993) 1.77
The binding of tetrodotoxin and alpha-bungarotoxin to normal and denervated mammalian muscle. J Physiol (1974) 1.73
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Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature (1980) 1.71
Neuronal-type Na+ and K+ channels in rabbit cultured Schwann cells. Nature (1984) 1.68
Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells. Proc Natl Acad Sci U S A (1985) 1.60
Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Proc Natl Acad Sci U S A (1986) 1.59
The ionic requirements for the action of acetylcholine on mammalian non-myelinated fibres. J Physiol (1963) 1.58
The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres. J Physiol (1972) 1.58
Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology (1995) 1.57
The binding of tritiated ouabain to mammalian non-myelinated nerve fibres. J Physiol (1970) 1.57
High conductance anion-selective channels in rat cultured Schwann cells. Proc R Soc Lond B Biol Sci (1984) 1.52
Energetic aspects of nerve conduction: the relationships between heat production, electrical activity and metabolism. Prog Biophys Mol Biol (1973) 1.50
A comparison of the effect of temperature, metabolic inhibitors and of ouabain on the electrogenic componen of the sodium pump in mammalian non-myelinated nerve fibres. J Physiol (1969) 1.49
Anomalous temperature dependence of the sodium conductance in rabbit nerve compared with frog nerve. Nature (1979) 1.48
The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesth Analg (1993) 1.47
On the voltage-dependent action of tetrodotoxin. Biophys J (1977) 1.47
Organization of ion channels in the myelinated nerve fiber. Science (1985) 1.44
Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. J Gen Physiol (1987) 1.42
The kinetics of the interaction between tetrodotoxin and mammalian nonmyelinated nerve fibers. Mol Pharmacol (1972) 1.39
A voltage-gated chloride conductance in rat cultured astrocytes. Proc R Soc Lond B Biol Sci (1986) 1.35
Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Mol Pharmacol (1999) 1.31
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Saxitoxin binding to sodium channels of rat skeletal muscles. J Physiol (1980) 1.29
The presence of voltage-gated sodium, potassium and chloride channels in rat cultured astrocytes. Proc R Soc Lond B Biol Sci (1985) 1.27
Evidence for the presence of potassium channels in the internode of frog myelinated nerve fibres. J Physiol (1982) 1.26
Binding of 125I-labeled reovirus to cell surface receptors. Virology (1984) 1.26
On the active form of 4-aminopyridine: block of K+ currents in rabbit Schwann cells. J Physiol (1991) 1.25
The movement of potassium ions during electrical activity, and the kinetics of the recovery process, in the non-myelinated fibres of the garfish olfactory nerve. J Physiol (1975) 1.25
On the relation between fibre diameter and conduction velocity in myelinated nerve fibres. Proc R Soc Lond B Biol Sci (1982) 1.23
Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction. J Gen Physiol (1993) 1.23
Mechanism of action of local anaesthetic agents and biotoxins. Br J Anaesth (1975) 1.22
Extraneuronal saxitoxin binding sites in rabbit myelinated nerve. Proc Natl Acad Sci U S A (1983) 1.22
A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology (1998) 1.21
High-STX-affinity vs. low-STX-affinity Na+ channel subtypes in nerve, heart, and skeletal muscle. Ann N Y Acad Sci (1986) 1.20
Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosens Mot Res (1994) 1.15
Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels. FEBS Lett (1990) 1.15
Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology (1994) 1.14
The heat production associated with the passage of a single impulse in pike olfactory nerve fibres. J Physiol (1975) 1.13
On the physiological role of internodal potassium channels and the security of conduction in myelinated nerve fibres. Proc R Soc Lond B Biol Sci (1984) 1.13
Two subtypes of sodium channel with tetrodotoxin sensitivity and insensitivity detected in denervated mammalian skeletal muscle. Brain Res (1985) 1.12
On the control of glycogenolysis in mammalian nervous tissue by calcium. J Physiol (1971) 1.10
The effect of the nerve sheath on the action of local anesthetics. J Pharmacol Exp Ther (1965) 1.10
Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster. Nature (1984) 1.08
Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus. Mol Pharmacol (1983) 1.08
Buccal oxytocin after amniotomy for induction of labour. Br Med J (1967) 1.08
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J (1990) 1.07
The operon encoding SubAB, a novel cytotoxin, is present in shiga toxin-producing Escherichia coli isolates from the United States. J Clin Microbiol (2007) 1.07
Increase in efflux of inorganic phosphate during electrical activity in small non-myelinated nerve fibres. J Physiol (1978) 1.07
Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C. J Neurosci (1988) 1.04
Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve. Anesthesiology (2001) 1.03
The binding of labelled tetrodotoxin and cobra toxin by the rat diaphragm. Br J Pharmacol (1973) 1.03
Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells. J Physiol (1992) 1.02
Sodium currents in Schwann cells from myelinated and non-myelinated nerves of neonatal and adult rabbits. J Physiol (1990) 1.02
Effects of the dipolar form of phloretin on potassium conductance in squid giant axons. Biophys J (1980) 1.02
Dependence of lidocaine potency on pH and PCO2. Anesth Analg (1987) 1.02
Block of human heart hH1 sodium channels by the enantiomers of bupivacaine. Anesthesiology (2000) 1.01
Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature. Anesth Analg (1987) 1.01
HPV prevalence and concordance in the cervix and oral cavity of pregnant women. Infect Dis Obstet Gynecol (2004) 1.01
Sodium channels in axons and glial cells of the optic nerve of Necturus maculosa. J Gen Physiol (1979) 1.00
The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels. J Membr Biol (1992) 1.00
The binding of labelled saxitoxin to the sodium channels in normal and denervated mammalian muscle, and in amphibian muscle. J Physiol (1977) 1.00
Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat. Pain (1999) 0.99
A calcium-activated cation-selective channel in rat cultured Schwann cells. Proc R Soc Lond B Biol Sci (1984) 0.99
Events in degenerating cat peripheral nerve: induction of Schwann cell S phase and its relation to nerve fibre degeneration. J Neurocytol (1986) 0.99
Loose patch clamp recording of ionic currents in demyelinated frog nerve fibers. Brain Res (1985) 0.99
Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Res (1990) 0.99
Binding of tetrodotoxin and saxitoxin to sodium channels. Philos Trans R Soc Lond B Biol Sci (1975) 0.98