Published in Risk Anal on September 01, 1986
Dose-response relationships for carcinogens: a review. Environ Health Perspect (1987) 1.20
Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database. Environ Health Perspect (1989) 1.15
Predicting the carcinogenicity of chemicals in humans from rodent bioassay data. Environ Health Perspect (1991) 0.86
Carcinogenic risk assessment: comparison of estimated safe doses for rats and mice. Environ Health Perspect (1987) 0.83
Ratcheting up cancer potency estimates. Environ Sci Technol (2012) 0.75
Alternative tests: carcinogenesis as an example. Environ Health Perspect (1998) 0.75
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1. Proc Natl Acad Sci U S A (1995) 3.68
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet (1999) 2.83
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr (1999) 2.71
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J (2001) 2.62
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res (2001) 2.62
A UV-sensitive mutant of Arabidopsis defective in the repair of pyrimidine-pyrimidinone(6-4) dimers. Science (1993) 2.28
Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses. Mol Cell Biol (2001) 2.28
Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J Natl Cancer Inst (2001) 2.17
A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res (1999) 2.13
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J Virol (1999) 2.09
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem (1995) 2.09
Common mechanism of toxicity: a case study of organophosphorus pesticides. Toxicol Sci (1998) 2.08
Teratogenic evaluation of 2,4,5-T. Science (1970) 1.83
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem (2001) 1.81
Estimation of risks of irreversible, delayed toxicity. J Toxicol Environ Health (1975) 1.74
Genetic variation in the 3' non-coding region of dengue viruses. Virology (2001) 1.71
Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology (2001) 1.71
Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. Am J Respir Cell Mol Biol (2000) 1.67
Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab (1983) 1.64
Intrascleral dissemination of infectious scleritis following pterygium excision. Br J Ophthalmol (1998) 1.63
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay. Carcinogenesis (1998) 1.61
Endoscopic features of metastatic tumors in the upper gastrointestinal tract. Endoscopy (1996) 1.59
Estimators of relative risk for case-control studies. Am J Epidemiol (1983) 1.58
Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice. J Exp Med (1990) 1.56
Estimation of the joint risk for multiple-compound exposure based on single-compound experiments. Risk Anal (1990) 1.46
Accumulation of heavy metals in leaf vegetables from agricultural soils and associated potential health risks in the Pearl River Delta, South China. Environ Monit Assess (2013) 1.45
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis. Oncogene (1999) 1.44
A power study of a sequential method of p-value adjustment for correlated continuous endpoints. J Biopharm Stat (1998) 1.40
Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas. Am J Pathol (1999) 1.38
Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells. Proc Natl Acad Sci U S A (1988) 1.37
An approximate unconditional test of non-inferiority between two proportions. Stat Med (2000) 1.37
Conjunctival transdifferentiation is due to the incomplete removal of limbal basal epithelium. Invest Ophthalmol Vis Sci (1990) 1.37
Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells. J Biol Chem (1984) 1.34
Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation. J Neurosci (2004) 1.30
Hemin enhances the differentiation of mouse 3T3 cells to adipocytes. Cell (1981) 1.27
Screening poly(dA/dT)- cDNAs for gene identification. Proc Natl Acad Sci U S A (2000) 1.27
The papillomavirus E6 proteins. Biochim Biophys Acta (1998) 1.26
EBV strain variation: geographical distribution and relation to disease state. Virology (1992) 1.23
Identification of survival motor neuron as a transcriptional activator-binding protein. Hum Mol Genet (1999) 1.22
Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation. J Biol Chem (1997) 1.21
Heme-regulated eIF-2alpha kinase purifies as a hemoprotein. Eur J Biochem (1998) 1.21
R1193Q of SCN5A, a Brugada and long QT mutation, is a common polymorphism in Han Chinese. J Med Genet (2005) 1.21
New ways of initiating translation in eukaryotes. Mol Cell Biol (2001) 1.20
Real-time implementation of electromyogram pattern recognition as a control command of man-machine interface. Med Eng Phys (1996) 1.19
Refined localization of a punctate palmoplantar keratoderma gene to a 5.06-cM region at 15q22.2-15q22.31. Br J Dermatol (2005) 1.17
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. J Biol Chem (2000) 1.13
Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China. Arch Dermatol Res (2007) 1.13
Linear interpolation algorithm for low dose risk assessment of toxic substances. J Environ Pathol Toxicol (1980) 1.13
Diagnostic accuracy of transesophageal echocardiography for detecting left atrial thrombi in patients with rheumatic heart disease having undergone mitral valve operations. Am J Cardiol (1993) 1.11
Localization of EMSP1 expression during tooth formation and cloning of mouse cDNA. J Dent Res (2000) 1.11
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. J Biol Chem (2001) 1.11
Issues in qualitative and quantitative risk analysis for developmental toxicology. Risk Anal (1988) 1.10
Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat Immunol (2001) 1.10
Accuracy of birth certificate data for detecting facial cleft defects in Arkansas children. Cleft Palate J (1979) 1.09
Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth development. J Dent Res (2000) 1.09
Sex differences in open-field behavior in the rat: the inductive and activational role of gonadal hormones. Physiol Behav (1975) 1.08
Inhibition of protein synthesis in insect cells by baculovirus-expressed heme-regulated eIF-2 alpha kinase. J Biol Chem (1994) 1.08
Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain. Alcohol Clin Exp Res (1997) 1.07
Performance of static standing balance in children with spastic diplegic cerebral palsy under altered sensory environments. Am J Phys Med Rehabil (1999) 1.06
The cellular location of dihydroorotate dehydrogenase: relation to de novo biosynthesis of pyrimidines. Arch Biochem Biophys (1976) 1.05
Value of peritoneal cytology in potentially resectable pancreatic cancer (Br J Surg 2013; 100: 1791-1796). Br J Surg (2014) 1.05
Tissue distribution and immunoreactivity of heme-regulated eIF-2 alpha kinase determined by monoclonal antibodies. Biochemistry (1991) 1.05
PARP alleles and SLE: failure to confirm association with disease susceptibility. J Clin Invest (2000) 1.04
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. Mol Pharmacol (2001) 1.04
Erythroid expression of the heme-regulated eIF-2 alpha kinase. Mol Cell Biol (1994) 1.04
Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: nitric oxide induces phosphorylation of initiation factor eIF-2 alpha. Mol Med (1998) 1.03
Ethanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci (1999) 1.03
Isolation and characterization of two knotted-like homeobox genes from tomato. Plant Mol Biol (1998) 1.03
The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress. Eur J Biochem (1997) 1.02
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. Blood (2000) 1.02
Incorporating model uncertainties along with data uncertainties in microbial risk assessment. Regul Toxicol Pharmacol (2000) 1.01
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ Health Perspect (1998) 1.01
Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. Biochemistry (2001) 1.01
Effects of dose and time in a long-term, low-dose carcinogenic study. J Environ Pathol Toxicol (1980) 1.00
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J Mol Cell Cardiol (2001) 1.00
Effects of a single session of prolonged muscle stretch on spastic muscle of stroke patients. Proc Natl Sci Counc Repub China B (2001) 0.99
Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). J Vasc Surg (1999) 0.98
Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. Biochemistry (2001) 0.97
Muscle insulin resistance in uremic humans: glucose transport, glucose transporters, and insulin receptors. Am J Physiol (1991) 0.97
The prognostic factors of severe amebic liver abscess: a retrospective study of 125 cases. Am J Trop Med Hyg (1992) 0.96
[Dissecting aneurysm of the aorta associated with local consumption coagulopathy]. Taiwan Yi Xue Hui Za Zhi (1990) 0.96
Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease. Neuroimage (2010) 0.96
Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes. Proc Natl Acad Sci U S A (1992) 0.95
Point estimates of cancer risk at low doses. Risk Anal (1994) 0.95
Diagnostic accuracy of transesophageal echocardiography for detecting patent ductus arteriosus in adolescents and adults. Chest (1995) 0.95
Genetic, molecular, and morphological analysis of compound leaf development. Curr Top Dev Biol (1999) 0.95
A phase II study evaluating the safety and efficacy of an adenovirus-ΔLMP1-LMP2 transduced dendritic cell vaccine in patients with advanced metastatic nasopharyngeal carcinoma. Ann Oncol (2011) 0.94
Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation. Mol Cell Biol (1994) 0.94
Time-course analysis of stretch reflexes in hemiparetic subjects using an on-line spasticity measurement system. J Electromyogr Kinesiol (2000) 0.94
Tumor necrosis factor a microsatellite polymorphism is associated with rheumatoid arthritis severity through an interaction with the HLA-DRB1 shared epitope. Arthritis Rheum (1999) 0.94
Chronic toxicity and carcinogenicity studies of gentian violet in mice. Fundam Appl Toxicol (1985) 0.93
A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: induction of lymph node homing and apoptosis upon secondary signaling through homing receptors. J Immunol (1999) 0.93
Nonlinearity and thresholds in dose-response relationships for carcinogenicity due to sampling variation, logarithmic dose scaling, or small differences in individual susceptibility. Toxicol Appl Pharmacol (2005) 0.93
Usefulness of transesophageal echocardiography in the treatment of critically ill patients. Chest (1993) 0.93
Acute exacerbation in patients with liver cirrhosis: a clinicopathological study. Liver (1990) 0.92
p53 amino acids 339-346 represent the minimal p53 repression domain. J Biol Chem (2001) 0.91
Comparison of transthoracic and transesophageal echocardiography in the diagnosis of intracardiac tumors in adults. J Clin Ultrasound (1994) 0.91
Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB. Nucleosides Nucleotides (1999) 0.91