Published in Methods Enzymol on January 01, 1987
Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol (1993) 3.73
Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol Cell Biol (1998) 1.68
Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol (1992) 1.44
DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Mol Cell Biol (2005) 1.41
The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras. Mol Cell Biol (1994) 1.29
Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension. J Cell Biol (1997) 1.28
The dual-specificity CLK kinase induces neuronal differentiation of PC12 cells. Mol Cell Biol (1994) 1.15
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A (1999) 1.14
Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proc Natl Acad Sci U S A (2001) 1.13
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol (2011) 1.06
Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene. J Virol (1994) 1.06
Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA. J Cell Biol (1993) 1.05
Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci U S A (2001) 1.00
Electrically evoking and electrochemically resolving quantal release on a microchip. Lab Chip (2009) 1.00
Upregulation of the SERCA-type Ca2+ pump activity in response to endoplasmic reticulum stress in PC12 cells. BMC Biochem (2001) 0.97
Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity. J Virol (1999) 0.95
Nerve growth factor-specific regulation of protein methylation during neuronal differentiation of PC12 cells. J Cell Biol (1997) 0.94
A protein encoded by the bovine herpesvirus 1 latency-related gene interacts with specific cellular regulatory proteins, including CCAAT enhancer binding protein alpha. J Virol (2006) 0.91
Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. PLoS One (2011) 0.89
D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro. Biochem J (2003) 0.89
High-resolution fractionation of signaling endosomes containing different receptors. Traffic (2009) 0.88
Expression and in vitro function of beta 1-integrin laminin receptors in the developing avian ciliary ganglion. J Neurosci (1995) 0.87
A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins. PLoS One (2015) 0.86
PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution. J Biomed Mater Res A (2009) 0.85
NGF causes TrkA to specifically attract microtubules to lipid rafts. PLoS One (2012) 0.83
Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation. Mol Cell Proteomics (2014) 0.82
Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells. Proc Natl Acad Sci U S A (1994) 0.79
The use of Epstein-Barr virus-based shuttle vectors in rat PC12 cells. Cell Mol Neurobiol (1997) 0.78
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. Int J Pept (2013) 0.78
Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown. BMC Neurosci (2010) 0.76
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells. J Nanobiotechnology (2012) 0.76
Density-dependent nerve growth factor regulation of Gs-alpha RNA in pheochromocytoma 12 cells. Mol Cell Biol (1990) 0.75
Rat Nasal Respiratory Mucosa-Derived Ectomesenchymal Stem Cells Differentiate into Schwann-Like Cells Promoting the Differentiation of PC12 Cells and Forming Myelin In Vitro. Stem Cells Int (2015) 0.75
Bioactivity-guided fractionation identifies amygdalin as a potent neurotrophic agent from herbal medicine Semen Persicae extract. Biomed Res Int (2014) 0.75
Differentiation of Bone Marrow Stem Cells into Schwann Cells for the Promotion of Neurite Outgrowth on Electrospun Fibers. ACS Appl Mater Interfaces (2017) 0.75
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A (1976) 21.06
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci (2001) 3.10
An outbreak of waterborne cryptosporidiosis caused by post-treatment contamination. Epidemiol Infect (1989) 3.06
The nerve growth factor: biochemistry, synthesis, and mechanism of action. Annu Rev Neurosci (1980) 2.61
Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nat Neurosci (2001) 2.59
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron (1994) 2.44
Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science (1986) 2.43
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity. Neuron (1992) 2.43
Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line. Nature (1977) 2.39
Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells. Nature (1975) 2.31
Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol (1978) 2.16
Binding of nerve growth factor receptor in sympathetic ganglia. Proc Natl Acad Sci U S A (1973) 2.14
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol (2001) 2.11
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron (1993) 2.01
Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor. Proc Natl Acad Sci U S A (1978) 2.00
Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor. J Cell Biol (1983) 1.96
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc Natl Acad Sci U S A (2000) 1.81
Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheo-chromocytoma cells. Brain Res (1977) 1.80
Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci (1999) 1.75
PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J Cell Biol (1986) 1.71
Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J Cell Biol (1991) 1.68
Neurotrophin signaling via Trks and p75. Exp Cell Res (1999) 1.65
An integrated procedure for the rapid diagnosis of biliary obstruction, portal hypertension and liver disease of uncertain etiology. N Engl J Med (1971) 1.63
Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line. Nature (1977) 1.58
Changes in the colchicine susceptibility of microtubules associated with neurite outgrowth: studies with nerve growth factor-responsive PC12 pheochromocytoma cells. J Cell Biol (1982) 1.56
Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J Neurosci (1991) 1.56
Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells. J Neurosci (1987) 1.56
Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J Neurosci (1997) 1.54
Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol (1998) 1.54
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem (2001) 1.53
Trophic support of cultured spiral ganglion neurons by depolarization exceeds and is additive with that by neurotrophins or cAMP and requires elevation of [Ca2+]i within a set range. J Neurosci (1997) 1.53
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci U S A (1988) 1.52
Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Lab Invest (1978) 1.49
Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP. J Cell Biol (1984) 1.48
Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor. J Cell Biol (1979) 1.48
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines. Cell (1991) 1.47
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron (1991) 1.46
Growth cone configuration and advance: a time-lapse study using video-enhanced differential interference contrast microscopy. J Neurosci (1988) 1.45
A dissociated cell culture bioassay for nerve growth factor. Neurobiology (1974) 1.45
Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol (1992) 1.44
Guanosine 3',5'-cyclic monophosphate and the in vitro physiology of frog photoreceptor membranes. J Gen Physiol (1977) 1.43
Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells. Mol Cell Biol (1987) 1.42
Fine structure of initial outgrowth of processes induced in a pheochromocytoma cell line (PC12) by nerve growth factor. J Neurocytol (1979) 1.41
The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization. J Cell Biol (1998) 1.39
Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem (1996) 1.37
NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cells. Cell (1978) 1.37
Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J Neurosci (2001) 1.36
Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowth. J Cell Biol (1986) 1.35
Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage. J Neurosci (2000) 1.33
Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res (2001) 1.33
G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis. J Neurosci (1997) 1.31
The role of transcription-dependent priming in nerve growth factor promoted neurite outgrowth. Dev Biol (1982) 1.31
Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron (2001) 1.30
A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein. J Cell Biol (1988) 1.30
Histofluorescence study of chromaffin cells in dissociated cell cultures of chick embryo sympathetic ganglia. J Neurobiol (1974) 1.29
N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci (1995) 1.29
Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons. J Neurosci (1999) 1.26
beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem (2001) 1.26
Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5. Oncogene (2006) 1.25
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem (2000) 1.24
CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J Neurochem (1999) 1.24
Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J Neurosci (1996) 1.24
Nerve growth factor-inducible large external (NILE) glycoprotein: studies of a central and peripheral neuronal marker. J Neurosci (1983) 1.23
Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci (1996) 1.23
Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment. Neurobiol Aging (2001) 1.22
Enzymatic activities of mouse nerve growth factor and its subunits. Proc Natl Acad Sci U S A (1968) 1.22
Ophthalmoscopic findings in subacute sclerosing panencephalitis. Br J Ophthalmol (1973) 1.21
Neuroendocrine neoplasms and their cells of origin. N Engl J Med (1977) 1.21
Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons. II. Sensory neurons. Dev Biol (1977) 1.21
Anal abnormalities in childhood myotonic dystrophy--a possible source of confusion in child sexual abuse. Arch Dis Child (1992) 1.21
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. J Neurosci (1998) 1.21
Variant forms of ataxia telangiectasia. J Med Genet (1987) 1.19
-Bungarotoxin used as a probe for acetylcholine receptors of cultured neurones. Nature (1973) 1.19
Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proc Natl Acad Sci U S A (1984) 1.19
Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase. J Cell Biol (1989) 1.19
Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor. J Biol Chem (1997) 1.17
Regulation of acetylcholinesterase activity by nerve growth factor. Role of transcription and dissociation from effects on proliferation and neurite outgrowth. J Biol Chem (1981) 1.16
Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol (1993) 1.16
The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc Natl Acad Sci U S A (1996) 1.16
Pit formation and rapid changes in surface morphology of sympathetic neurons in response to nerve growth factor. J Cell Biol (1981) 1.15
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci U S A (2000) 1.14
Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line. J Cell Biol (1984) 1.14
Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro. J Neurosci (2001) 1.14
Subunit interaction and enzymatic activity of mouse 7S nerve growth factor. Biochemistry (1969) 1.12
Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol (1993) 1.12
Release of (3H)norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation. Brain Res (1977) 1.12
Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci (1998) 1.11
Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowth. Nature (1978) 1.11
Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neuroscience (1990) 1.11
Nerve growth factor-induced increase in saxitoxin binding to rat PC12 pheochromocytoma cells. J Neurosci (1982) 1.10