PubRank

D M Ornitz

Author PubWeight™ 92.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991 8.99
2 Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996 4.54
3 An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1987 4.48
4 Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev 1994 3.97
5 Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 1998 2.90
6 Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 1996 2.87
7 Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 1985 2.77
8 Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 1998 2.40
9 Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 2001 2.40
10 Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 1999 2.35
11 Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 1987 2.32
12 Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 2001 2.16
13 Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc Natl Acad Sci U S A 2000 2.13
14 The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol Cell Biol 1987 2.12
15 Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc Natl Acad Sci U S A 2001 1.96
16 The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol 1999 1.87
17 FGF signaling in skeletal development. Front Biosci 1998 1.81
18 Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 2000 1.79
19 Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med 1998 1.76
20 Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev Dyn 1999 1.63
21 Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice. Cold Spring Harb Symp Quant Biol 1985 1.63
22 Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J Biol Chem 1994 1.61
23 Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14. Mech Dev 2000 1.57
24 Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains. Development 2001 1.46
25 FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 1995 1.42
26 Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev 1999 1.36
27 Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2. Proc Natl Acad Sci U S A 1998 1.29
28 Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes. J Biol Chem 1997 1.19
29 Development and maintenance of otoconia: biochemical considerations. Ann N Y Acad Sci 2001 1.14
30 Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. J Biol Chem 1999 1.14
31 Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development 2001 1.09
32 Nitrate reductase from Penicillium chrysogenum. Purification and kinetic mechanism. J Biol Chem 1981 1.08
33 Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J Biol Chem 1998 1.04
34 Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation. J Neurosci 2006 1.03
35 Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound. J Clin Invest 1997 1.02
36 Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J 1994 1.01
37 Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Proc Natl Acad Sci U S A 1996 0.99
38 Transplanted oligodendrocyte progenitor cells expressing a dominant-negative FGF receptor transgene fail to migrate in vivo. J Neurosci 1997 0.99
39 Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. Oncogene 1992 0.98
40 Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes. Proc Natl Acad Sci U S A 2001 0.97
41 MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Oncogene 1998 0.97
42 Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. J Biol Chem 1997 0.93
43 Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells. J Bone Miner Res 2000 0.92
44 Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem 1996 0.91
45 The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF. J Neurosci 1996 0.90
46 Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1. Mol Cell Biol 1998 0.90
47 Identification and characterization of a novel member of the fibroblast growth factor family. Eur J Neurosci 1998 0.89
48 High-resolution mapping of tlt, a mouse mutant lacking otoconia. Mamm Genome 1999 0.88
49 Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model. J Urol 1993 0.87
50 Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Genomics 2001 0.84
51 Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15. Genomics 1999 0.83
52 Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3',5'-monophosphate. Identification of a chondrocytic regulatory element. J Biol Chem 1999 0.81
53 A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5. Genomics 2000 0.81
54 Tissue-specific expression of pancreatic genes in transgenic mice. Ann N Y Acad Sci 1986 0.81
55 Determination of fibroblast growth factor receptor expression in mouse, rat and human samples using a single primer pair. Biotechniques 1997 0.75
56 BK1: an FGF-responsive central nervous system-derived cell line. Growth Factors 1995 0.75
57 Targeted expression of cloned genes in transgenic mice. Prog Brain Res 1987 0.75