Published in Mol Cell Biol on August 01, 1987
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer. Mol Cell Biol (1988) 3.11
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest (2007) 2.92
Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice. Mol Cell Biol (1989) 2.24
Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc Natl Acad Sci U S A (1991) 2.16
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A (2005) 1.87
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol Cell Biol (1989) 1.80
Functional dissection of the lck proximal promoter. Mol Cell Biol (1992) 1.78
Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol (1993) 1.75
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J Exp Med (1989) 1.67
Interactions between the promoter and first intron are involved in transcriptional control of alpha 1(I) collagen gene expression. Mol Cell Biol (1988) 1.49
Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism. Proc Natl Acad Sci U S A (1989) 1.40
An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J (2003) 1.34
Analysis of the mouse protamine 1 promoter in transgenic mice. Proc Natl Acad Sci U S A (1993) 1.31
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol (2008) 1.31
The cell-specific elastase I enhancer comprises two domains. Mol Cell Biol (1988) 1.26
A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J (1988) 1.18
A 500-bp region, approximately 40 kb upstream of the human CYP19 (aromatase) gene, mediates placenta-specific expression in transgenic mice. Proc Natl Acad Sci U S A (1999) 1.08
A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. Mol Cell Biol (1994) 1.07
The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development. Mol Cell Biol (1990) 1.06
Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells. Mol Cell Biol (1988) 1.05
Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers. Mol Cell Biol (1987) 1.04
Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase. Mol Cell Biol (1995) 1.04
Expression from the transferrin gene promoter in transgenic mice. Mol Cell Biol (1989) 0.99
Expression of the third member of the serum amyloid A gene family in mouse adipocytes. J Exp Med (1989) 0.99
Organ injury associated with extrathymic induction of immune tolerance in doubly transgenic mice. Proc Natl Acad Sci U S A (1992) 0.94
Cooperation between elements of an organ-specific transcriptional enhancer in animals. Mol Cell Biol (1995) 0.94
Regulatory regions of rat insulin I gene necessary for expression in transgenic mice. Nucleic Acids Res (1991) 0.94
Mutagenesis in rodents using the L1 retrotransposon. Genome Biol (2007) 0.92
Binding of a pancreatic nuclear protein is correlated with amylase enhancer activity. Nucleic Acids Res (1989) 0.90
Erythroid expression and DNAaseI-hypersensitive sites of the carbonic anhydrase 1 gene. Biochem J (1992) 0.87
Exocrine pancreas transcription factor 1 binds to a bipartite enhancer element and activates transcription of acinar genes. Mol Cell Biol (1991) 0.86
A C/EBP-binding site in the transferrin promoter is essential for expression in the liver but not the brain of transgenic mice. Mol Cell Biol (1993) 0.86
Pancreatic acinar cell-specific overexpression of group 1B phospholipase A2 exacerbates diet-induced obesity and insulin resistance in mice. Int J Obes (Lond) (2010) 0.84
A mouse oocyte-specific protein that binds to a region of mZP3 promoter responsible for oocyte-specific mZP3 gene expression. Mol Cell Biol (1992) 0.84
Transactivation of pancreas-specific gene sequences in somatic cell hybrids. Mol Cell Biol (1991) 0.76
BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion. Diabetes (2015) 0.75
The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol (2016) 0.75
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A (1972) 83.88
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell (1983) 18.86
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (1985) 9.78
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Recovery of DNA segments from agarose gels. Anal Biochem (1980) 5.66
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Cell (1985) 3.99
Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature (1984) 3.68
Developmental regulation of a cloned adult beta-globin gene in transgenic mice. Nature (1985) 3.63
Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene. Cell (1983) 3.62
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Selected topics in chromatin structure. Annu Rev Genet (1985) 3.18
Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature (1985) 2.79
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme gene. Nature (1984) 2.69
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59
Short and long range activation by the SV40 enhancer. Nucleic Acids Res (1984) 2.35
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell (1987) 2.32
The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. DNA (1982) 2.32
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Cell-specific enhancers in the rat exocrine pancreas. Proc Natl Acad Sci U S A (1986) 2.02
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature (1984) 2.00
Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol (1985) 1.94
Concentrated, digestible DNA after hydroxylapatite chromatography with cetylpyridinium bromide precipitation. Anal Biochem (1983) 1.79
Relationship of nuclear estrogen receptor levels to induction of ovalbumin and conalbumin mRNA in chick oviduct. J Biol Chem (1977) 1.70
Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice. Cold Spring Harb Symp Quant Biol (1985) 1.63
Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences. Biochemistry (1982) 1.57
Tissue-specific expression of rat myosin light-chain 2 gene in transgenic mice. Nature (1985) 1.53
Structure of the two related elastase genes expressed in the rat pancreas. J Biol Chem (1984) 1.43
Rapid electroelution of nucleic acids from agarose and acrylamide gels. Anal Biochem (1982) 1.42
Selective expression of rat pancreatic genes during embryonic development. Proc Natl Acad Sci U S A (1986) 1.41
Hormonal stimulation in the exocrine pancreas results in coordinate and anticoordinate regulation of protein synthesis. J Cell Biol (1984) 1.33
Germline and somatic mosaicism in transgenic mice. Dev Biol (1986) 1.18
Proteins synthesized and secreted during rat pancreatic development. J Cell Biol (1980) 1.09
Regulation of specific protein synthesis in cytodifferentiation. J Cell Physiol (1968) 1.04
Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. Nucleic Acids Res (1986) 1.01
Two distinct adaptive responses in the synthesis of exocrine pancreatic enzymes to inverse changes in protein and carbohydrate in the diet. Am J Physiol (1984) 0.94
Transgenic progeny inherit tissue-specific expression of rat elastase I genes. DNA (1986) 0.82
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry (1974) 11.67
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem (1979) 9.48
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76
Isolation of RNA using guanidinium salts. Methods Enzymol (1987) 4.62
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55
Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet (1996) 4.54
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev (1994) 3.97
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67
Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26
Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25
Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18
Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17
The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med (1974) 3.17
Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate. J Biol Chem (1973) 3.13
Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
Transplantation of testis germinal cells into mouse seminiferous tubules. Int J Dev Biol (1997) 3.10
ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A (1996) 3.06
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet (1996) 2.87
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction. J Biol Chem (1972) 2.76
Quantitation of parameters that determine the rate of ovalbumin synthesis. Cell (1975) 2.74
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59
Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58
Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57