Published in Brain Res on April 16, 1986
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov (2009) 3.26
Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. Neurology (2012) 1.67
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A (2005) 1.51
Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial. J Neurol Neurosurg Psychiatry (2001) 1.44
Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc Natl Acad Sci U S A (2001) 1.09
Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography. Eur J Nucl Med Mol Imaging (2010) 1.05
The apolipoprotein E gene, attention, and brain function. Neuropsychology (2002) 1.05
Acetylcholine receptors in dementia and mild cognitive impairment. Eur J Nucl Med Mol Imaging (2008) 0.96
Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry (1987) 0.96
Disease-modifying drugs in Alzheimer's disease. Drug Des Devel Ther (2013) 0.92
Mild cognitive impairment: diagnosis, longitudinal course, and emerging treatments. Curr Psychiatry Rep (2014) 0.89
Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. Proc Natl Acad Sci U S A (1990) 0.88
Effect of acute and subchronic nicotine treatment on cortical acetylcholine release and on nicotinic receptors in rats and guinea-pigs. Br J Pharmacol (1989) 0.83
Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography. J Neurol Neurosurg Psychiatry (2006) 0.83
Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release. J Psychiatry Neurosci (1993) 0.83
Brain imaging of nicotinic receptors in Alzheimer's disease. Int J Alzheimers Dis (2010) 0.82
Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex. Cell Mol Life Sci (2014) 0.82
Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist. Invert Neurosci (1998) 0.82
Smoking and dementia of Alzheimer type. J Neurol Neurosurg Psychiatry (1987) 0.82
Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration. Synapse (2010) 0.81
Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice. Front Aging Neurosci (2014) 0.78
Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed α4β2 nicotinic receptors. J Biol Chem (2011) 0.77
Recent advances in the understanding of dementia. Postgrad Med J (1988) 0.75
[Relations between specific neurochemical systems and memory: problems posed by dementia of the Alzheimer type]. J Psychiatry Neurosci (1995) 0.75
Nicotine: abused substance and therapeutic agent. J Psychiatry Neurosci (1998) 0.75
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16
Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: ethical challenges. Am J Bioeth (2009) 6.13
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. N Engl J Med (1992) 5.93
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (1982) 5.63
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49
Alzheimer's disease: a disorder of cortical cholinergic innervation. Science (1983) 4.40
Evaluation of dementia. N Engl J Med (1996) 4.29
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06
Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology (2001) 3.74
Neurology and psychiatry: closing the great divide. Neurology (2000) 3.68
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A (1994) 3.36
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23
The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry (2001) 3.20
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol (1992) 3.20
The glutamatergic basis of human alcoholism. Am J Psychiatry (1995) 3.20
Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol (1981) 3.18
A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal (1996) 3.18
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron (1989) 3.06
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev (1999) 2.76
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci (1991) 2.73
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol (1990) 2.66
Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol (1996) 2.56
Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol Dis (2001) 2.53
The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective. JAMA (1997) 2.45
A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry (1999) 2.44
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol (1997) 2.43
Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36
D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry (1998) 2.36
Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J Virol (2000) 2.26
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A (2008) 2.25
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J Biol Chem (1997) 2.24
Botulinum toxin: mechanism of presynaptic blockade. Science (1976) 2.19
Donepezil and flight simulator performance: effects on retention of complex skills. Neurology (2002) 2.14
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci U S A (1995) 2.12
Emerging antidementia drugs: a preliminary ethical view. J Am Geriatr Soc (1998) 2.11
Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proc Natl Acad Sci U S A (1993) 2.10
Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am J Kidney Dis (1997) 2.09
Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology (2007) 2.09
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons. Mol Pharmacol (1971) 2.08
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature (1976) 2.08
Basal forebrain neurons in the dementia of Parkinson disease. Ann Neurol (1983) 2.06
Control of axonal caliber by neurofilament transport. J Cell Biol (1984) 2.03
Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J Neurosci (1994) 2.00
Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J Neurosci (1998) 2.00
Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration. Science (1978) 2.00
Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates. J Pharmacol Exp Ther (1969) 1.99
Automated microscopy system for mosaic acquisition and processing. J Microsc (2006) 1.98
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length. Neurobiol Dis (1998) 1.96
New perspectives on Alzheimer's disease. Annu Rev Neurosci (1986) 1.95
Fairhill guidelines on ethics of the care of people with Alzheimer's disease: a clinical summary. Center for Biomedical Ethics, Case Western Reserve University and the Alzheimer's Association. J Am Geriatr Soc (1995) 1.94
Protein topology of presenilin 1. Neuron (1996) 1.94
Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron (1998) 1.90
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry (2008) 1.88
Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. J Virol (2001) 1.86
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat Med (1997) 1.86
Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J (1990) 1.86
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging (1998) 1.81
Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action. Science (1969) 1.81
Comparative evaluation of synaptophysin-based methods for quantification of synapses. J Neurocytol (1996) 1.80
Dopaminergic dsyfunction in Tourette syndrome. Ann Neurol (1982) 1.79
Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science (1983) 1.78
Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience (1991) 1.78
Role of the beta-amyloid protein in Alzheimer's disease. FASEB J (1995) 1.75
Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet (1993) 1.74
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J Pharmacol Exp Ther (1999) 1.73
The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med (1998) 1.72
Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry (1995) 1.71
Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. I. Cell proliferation. J Comp Neurol (1976) 1.71
Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A (1998) 1.71
Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc Natl Acad Sci U S A (1996) 1.70
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A (2000) 1.70
Age-related spatial reference and working memory deficits assessed in the water maze. Neurobiol Aging (1995) 1.69
AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience (1993) 1.66
Pilot studies of telemedicine for patients with obsessive-compulsive disorder. Am J Psychiatry (1995) 1.66
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. J Biol Chem (1987) 1.64
Speaking of research advance directives: planning for future research participation. Neurology (2006) 1.61
Regulatable gene expression systems for gene therapy applications: progress and future challenges. Mol Ther (2005) 1.61
Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin. J Comp Neurol (1976) 1.61
Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proc Natl Acad Sci U S A (2002) 1.60
Quality of Life in Dementia: state of the art--report of the International Working Group for Harmonization of Dementia Drug Guidelines and the Alzheimer's Society satellite meeting. Alzheimer Dis Assoc Disord (2001) 1.60
Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron (1992) 1.60
Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. J Neurochem (1992) 1.58
Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol (1997) 1.57
Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology (2008) 1.57
Diseases of meaning, manifestations of health, and metaphor. J Altern Complement Med (1999) 1.56
Neurofibrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol (1988) 1.56
Effect of intermittent high dose parenteral corticosteroids on the alveolitis of idiopathic pulmonary fibrosis. Am Rev Respir Dis (1983) 1.56