Effects of PS1 deficiency on membrane protein trafficking in neurons.

PubWeight™: 1.90‹?› | Rank: Top 3%

🔗 View Article (PMID 9856475)

Published in Neuron on November 01, 1998

Authors

S Naruse1, G Thinakaran, J J Luo, J W Kusiak, T Tomita, T Iwatsubo, X Qian, D D Ginty, D L Price, D R Borchelt, P C Wong, S S Sisodia

Author Affiliations

1: Department of Pharmacological and Physiological Sciences, The University of Chicago, Illinois 60637, USA.

Articles citing this

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A (1999) 2.82

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiol Genomics (2008) 2.11

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J Cell Biol (1999) 2.03

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med (2012) 2.02

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proc Natl Acad Sci U S A (2004) 1.76

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65

Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A (2010) 1.62

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci U S A (2007) 1.49

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (2006) 1.48

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J Cell Biol (2001) 1.46

CD74 is a member of the regulated intramembrane proteolysis-processed protein family. Mol Biol Cell (2005) 1.42

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A (2006) 1.41

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol (2004) 1.39

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci (2007) 1.39

Pathological and physiological functions of presenilins. Mol Neurodegener (2006) 1.38

Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A (2000) 1.30

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A (2004) 1.21

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proc Natl Acad Sci U S A (2001) 1.16

β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13

Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. J Gen Physiol (2001) 1.13

Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase. J Biol Chem (2012) 1.10

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A (2005) 1.07

Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J Neurosci (2009) 1.06

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet (2008) 1.06

Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh Migr (2009) 1.05

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J Cell Biol (1999) 1.04

Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLoS Biol (2008) 1.03

Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? Future Neurol (2009) 1.02

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep (2013) 1.00

The role of presenilins in Alzheimer's disease. J Clin Invest (1999) 0.98

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production. Biochem J (2004) 0.97

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. PLoS One (2010) 0.97

Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A (2007) 0.93

Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity. J Biol Chem (2011) 0.92

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain. J Med Genet (2001) 0.91

Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease. Pharmacol Ther (2013) 0.90

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Mol Neurodegener (2012) 0.90

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Curr Genomics (2007) 0.90

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiol Aging (2012) 0.87

Function and dysfunction of the presenilins. Am J Hum Genet (1999) 0.87

Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping. EMBO J (2016) 0.86

A novel mechanism for the regulation of amyloid precursor protein metabolism. J Cell Biol (2002) 0.86

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime. Biochem Soc Trans (2013) 0.86

Structural biology of presenilins and signal peptide peptidases. J Biol Chem (2013) 0.85

Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci (2014) 0.84

Protein aggregates and dementia: is there a common toxicity? J Neurol Neurosurg Psychiatry (2002) 0.84

Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci (2010) 0.84

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry (2009) 0.84

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation. Alzheimers Res Ther (2013) 0.83

Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages. Dev Cell (2012) 0.82

Genetic studies in Alzheimer's disease. Dialogues Clin Neurosci (2003) 0.82

Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution. J Alzheimers Dis (2010) 0.80

Early onset Alzheimer's disease and oxidative stress. Oxid Med Cell Longev (2014) 0.79

Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. Int J Alzheimers Dis (2010) 0.78

Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation. Mol Cell Biol (2008) 0.78

APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment. Alzheimers Res Ther (2015) 0.77

Presenilin promotes dietary copper uptake. PLoS One (2013) 0.76

Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein. PLoS One (2013) 0.76

Twenty Years of Presenilins-Important Proteins in Health and Disease. Mol Med (2015) 0.75

Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol Aging (2016) 0.75

Articles by these authors

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology (2005) 21.67

Cable properties of smooth muscle. J Physiol (1968) 8.93

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (1982) 5.63

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol (1998) 5.47

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14

Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell (1987) 5.12

Light-induced resistance changes in single photoreceptors of Necturus and Gekko. Vision Res (1969) 5.04

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (1996) 4.96

A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet (1995) 4.95

Neuropilin is a semaphorin III receptor. Cell (1997) 4.88

Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev (1993) 4.69

Electrical responses of smooth muscle to external stimulation in hypertonic solution. J Physiol (1966) 4.69

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49

Alzheimer's disease: a disorder of cortical cholinergic innervation. Science (1983) 4.40

A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol (1998) 4.26

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06

Membrane capacity and resistance of mammalian smooth muscle. J Theor Biol (1966) 3.83

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science (1993) 3.71

Increase of membrane conductance by adrenaline in the smooth muscle of guinea-pig taenia coli. Proc R Soc Lond B Biol Sci (1969) 3.66

Electrophysiological study of the mechanisms subserving color coding in the fish retina. Cold Spring Harb Symp Quant Biol (1965) 3.65

Identification of rhythmically active cells in guinea-pig stomach. J Physiol (1999) 3.38

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A (1994) 3.36

A case of concomitant tuberculosis and sarcoidosis with mycobacterial DNA present in the sarcoid lesion. Chest (1998) 3.25

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (1987) 3.23

Current spread in the smooth muscle of the guinea-pig vas deferens. J Physiol (1967) 3.21

Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol (1981) 3.18

A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal (1996) 3.18

Properties of the inhibitory potential of smooth muscle as observed in the response to field stimulation of the guinea-pig taenia coli. J Physiol (1967) 3.17

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell (1992) 3.17

Electrical activity of vertebrate photoreceptors. Q Rev Biophys (1970) 3.16

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science (1999) 3.13

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet (2000) 3.07

Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci (1998) 3.03

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron (2001) 2.92

Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle. Am J Physiol (1973) 2.91

Studies on the mass receptor potential of the isolated frog retina. II. On the basis of the ionic mechanism. Vision Res (1969) 2.91

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron (1995) 2.90

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology (2007) 2.86

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci (1991) 2.73

The action potential in the smooth muscle of the guinea pig taenia coli and ureter studied by the double sucrose-gap method. J Gen Physiol (1970) 2.68

A security mediator for health care information. Proc AMIA Annu Fall Symp (1996) 2.57

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol Dis (2001) 2.53

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann Neurol (1998) 2.47

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol (1999) 2.47

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron (1995) 2.45

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol (1997) 2.43

Catecholamine action on smooth muscle. Pharmacol Rev (1987) 2.43

Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton-Valentine leukocidin genes. Gene (1998) 2.43

The effect of sodium and calcium on the action potential of the smooth muscle of the guinea-pig taenia coli. J Physiol (1969) 2.39

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet (1998) 2.39

Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg (2001) 2.38

Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36

Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Nature (1989) 2.36

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron (1994) 2.34

Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron (1998) 2.33

Spectral response curves of single cones in the carp. Vision Res (1967) 2.30

The slow wave in the circular muscle of the guinea-pig stomach. J Physiol (1975) 2.29

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem (2000) 2.27

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A (1993) 2.27

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem (1996) 2.27

Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron (2000) 2.25

Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol (1998) 2.25

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A (2008) 2.25

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J Biol Chem (1997) 2.24

Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun (1989) 2.23

Spike propagation in the smooth muscle of the guinea-pig taenia coli. J Physiol (1967) 2.23

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci (1999) 2.21

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20