Split genes and RNA splicing.

Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 11.24

RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34

BKV splice sequences based on analysis of preferred donor and acceptor sites. Nucleic Acids Res (1979) 4.86

Exons encode functional and structural units of chicken lysozyme. Proc Natl Acad Sci U S A (1980) 4.01

Has the endosymbiont hypothesis been proven? Microbiol Rev (1982) 3.86

Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications. Proc Natl Acad Sci U S A (1986) 3.50

Selfish DNA: a sexually-transmitted nuclear parasite. Genetics (1983) 3.31

Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. Proc Natl Acad Sci U S A (1980) 3.19

Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A (1979) 3.05

Exon shuffling generates an immunoglobulin heavy chain gene. Proc Natl Acad Sci U S A (1980) 2.80

Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. Proc Natl Acad Sci U S A (1981) 2.65

Nucleotide sequence of a ribosomal RNA gene intron from slime mold Physarum polycephalum. Proc Natl Acad Sci U S A (1981) 2.32

Rates of intron loss and gain: implications for early eukaryotic evolution. Proc Natl Acad Sci U S A (2005) 2.10

Physical parameters affecting the rate and completion of RNA driven hybridization of DNA: new measurements relevant to quantitation based on kinetics. Nucleic Acids Res (1982) 2.02

Intervening sequences in a Dictyostelium gene that encodes a low abundance class mRNA. Nucleic Acids Res (1980) 1.82

Modular structural units, exons, and function in chicken lysozyme. Proc Natl Acad Sci U S A (1983) 1.75

Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain. Proc Natl Acad Sci U S A (1980) 1.73

Origins of recently gained introns in Caenorhabditis. Proc Natl Acad Sci U S A (2004) 1.73

Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA. Nucleic Acids Res (1980) 1.71

Modular organization of inteins and C-terminal autocatalytic domains. Protein Sci (1998) 1.64

Characterization of globin domains: heme binding to the central exon product. Proc Natl Acad Sci U S A (1980) 1.63

Circular RNAs: relics of precellular evolution? Proc Natl Acad Sci U S A (1989) 1.63

Accurate and efficient in vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome. Nucleic Acids Res (1983) 1.63

The absence of introns within a human fibroblast interferon gene. Nucleic Acids Res (1981) 1.63

Fine structure and evolution of the rat serum albumin gene. Mol Cell Biol (1981) 1.62

Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived "portable exons" carrying the Escherichia coli lacZ gene. Proc Natl Acad Sci U S A (1989) 1.61

Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor. EMBO J (1983) 1.60

Internal structure of a mitochondrial intron of Aspergillus nidulans. Proc Natl Acad Sci U S A (1982) 1.53

New chimeric splice junction in adenovirus type 2-simian virus 40 hybrid viral mRNA. J Virol (1980) 1.53

Are viroids escaped introns? Proc Natl Acad Sci U S A (1981) 1.52

Viroid processing: a model involving the central conserved region and hairpin I. Proc Natl Acad Sci U S A (1986) 1.49

Evolution of DNA sequence organization in mitochondrial genomes of Zea. Proc Natl Acad Sci U S A (1981) 1.47

The sequences homologous to major interspersed repeats B1 and B2 of mouse genome are present in mRNA and small cytoplasmic poly(A) + RNA. Nucleic Acids Res (1982) 1.40

The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A (1999) 1.39

Cotransfer of linked eukaryotic genes and efficient transfer of hypoxanthine phosphoribosyltransferase by DNA-mediated gene transfer. Proc Natl Acad Sci U S A (1980) 1.38

Nuclear RNA transcripts from Drosophila melanogaster ribosomal RNA genes containing introns. Nucleic Acids Res (1980) 1.38

Mystery of intron gain. Genome Res (2003) 1.33

The chicken conalbumin gene: studies of the organization of cloned DNAs. Nucleic Acids Res (1979) 1.31

In vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome. Proc Natl Acad Sci U S A (1981) 1.28

Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number. Genome Res (2006) 1.26

The nucleotide sequence of the chicken apo very low density lipoprotein II gene. Nucleic Acids Res (1983) 1.18

Nonsense-mediated decay enables intron gain in Drosophila. PLoS Genet (2010) 1.17

Presence of albumin mRNA precursors in nuclei of analbuminemic rat liver lacking cytoplasmic albumin mRNA. Proc Natl Acad Sci U S A (1982) 1.17

Nucleotide sequence of the satellite of peanut stunt virus reveals structural homologies with viroids and certain nuclear and mitochondrial introns. Proc Natl Acad Sci U S A (1985) 1.12

The William Allan Memorial Award Address: Gene clusters, Genome organization, and complex phenotypes. When the sequence is known, what will it mean? Am J Hum Genet (1981) 1.11

A mutational analysis of U12-dependent splice site dinucleotides. RNA (2005) 1.11

Regulatory interactions between mitochondrial genes: interactions between two mosaic genes. Proc Natl Acad Sci U S A (1981) 1.10

Nucleotide sequence of influenza virus RNA segment 8 indicates that coding regions for NS1 and NS2 proteins overlap. Proc Natl Acad Sci U S A (1980) 1.09

Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes. Nucleic Acids Res (1986) 1.06

In vitro-synthesized adenovirus 2 messenger RNA precursors are accurately spliced by nuclear extracts. Proc Natl Acad Sci U S A (1984) 1.05

Ribonuclease "XlaI," an activity from Xenopus laevis oocytes that excises intervening sequences from yeast transfer ribonucleic acid precursors. Mol Cell Biol (1981) 1.05

Large-scale intron conservation and order-of-magnitude variation in intron loss/gain rates in apicomplexan evolution. Genome Res (2006) 1.05

Multiple polyadenylation sites in a Drosophila tropomyosin gene are used to generate functional mRNAs. Nucleic Acids Res (1985) 1.04

Synthesis, restriction analysis, and molecular cloning of near full length DNA complementary to bovine parathyroid hormone mRNA. Nucleic Acids Res (1980) 1.03

Primate and rodent specific intron gains and the origin of retrogenes with splice variants. Mol Biol Evol (2010) 1.02

Porcine vinculin and metavinculin differ by a 68-residue insert located close to the carboxy-terminal part of the molecule. EMBO J (1988) 1.02

Genomics of alternative splicing: evolution, development and pathophysiology. Hum Genet (2014) 1.01

DNA organisation in the chicken lysozyme gene region. Nucleic Acids Res (1981) 1.01

Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A (1984) 1.01

Mechanisms of intron gain and loss in Drosophila. BMC Evol Biol (2011) 1.00

Identifying the mechanisms of intron gain: progress and trends. Biol Direct (2012) 0.98

The origin of recent introns: transposons? Genome Biol (2004) 0.97

In vitro splicing of the ribosomal RNA precursor in isolated nucleoli from Tetrahymena. Nucleic Acids Res (1980) 0.96

Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems. Proc Natl Acad Sci U S A (1982) 0.94

Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic Acids Res (1980) 0.92

Darwin and the scientific method. Proc Natl Acad Sci U S A (2009) 0.91

Could poly(A) align the splicing sites of messenger RNA precursors? Proc Natl Acad Sci U S A (1980) 0.88

Intronization, de-intronization and intron sliding are rare in Cryptococcus. BMC Evol Biol (2009) 0.87

Introns excised from immunoglobulin pre-mRNAs exist as discrete species. Mol Cell Biol (1984) 0.86

Contributions of microbiology to eucaryotic cell biology: new directions for microbiology. Microbiol Rev (1979) 0.86

A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins. BMC Genomics (2014) 0.86

Some sequence similarities among cloned mouse DNA segments that code for lambda and kappa light chains of immunoglobulins. Proc Natl Acad Sci U S A (1979) 0.85

General occurrence and transcription of intervening sequences in mouse genes expressed via polyadenylated mRNA. Nucleic Acids Res (1980) 0.85

A genome-wide identification and analysis of the basic helix-loop-helix transcription factors in the ponerine ant, Harpegnathos saltator. BMC Evol Biol (2012) 0.80

Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids. Proc Natl Acad Sci U S A (1981) 0.80

Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs. PLoS One (2011) 0.80

Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. BMC Evol Biol (2010) 0.79

Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation. World J Biol Chem (2014) 0.79

In vitro splicing of SV40 late mRNA in isolated nuclei from CV-1 cells. Nucleic Acids Res (1980) 0.78

U12-type spliceosomal introns of Insecta. Int J Biol Sci (2012) 0.76

Functional cDNA expression cloning: pushing it to the limit. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.75

A Genome-Wide Identification and Analysis of the Basic Helix-Loop-Helix Transcription Factors in Brown Planthopper, Nilaparvata lugens. Genes (Basel) (2016) 0.75

The precursor to animal cell messenger RNA. Biochem J (1981) 0.75

Central dogma of molecular biology. Nature (1970) 5.89

Diffusion in embryogenesis. Nature (1970) 5.66

The double helix: a personal view. Nature (1974) 4.56

Function of the thalamic reticular complex: the searchlight hypothesis. Proc Natl Acad Sci U S A (1984) 3.93

General model for the chromosomes of higher organisms. Nature (1971) 3.59

The function of dream sleep. Nature (1983) 2.47

Memory and molecular turnover. Nature (1984) 2.23

Neural edelmanism. Trends Neurosci (1989) 1.48

Long axons within the striate cortex: their distribution, orientation, and patterns of connection. Proc Natl Acad Sci U S A (1982) 1.13

The zombie within. Nature (2001) 0.98

Molecular biology in the year 2000. Nature (1970) 0.97

Visual perception: rivalry and consciousness. Nature (1996) 0.96

[Central dogma of mollecular biology]. Tsitologiia (1971) 0.77

The domestic animals of science. Riv Biol (1980) 0.75

Crick looks back on DNA. Science (1979) 0.75

[Molecular biology in the year 2000. 1970]. Bioorg Khim (2000) 0.75

DNA today. Perspect Biol Med (1982) 0.75