Published in J Biol Chem on November 25, 1986
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci U S A (1998) 2.32
Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proc Natl Acad Sci U S A (1988) 1.86
Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev (2013) 1.68
Molecular mechanisms of drug resistance. Biochem J (1990) 1.56
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc Natl Acad Sci U S A (1988) 1.43
Chemosensitization of tumors by resveratrol. Ann N Y Acad Sci (2011) 1.41
Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy. Proc Natl Acad Sci U S A (1991) 1.37
An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue. Am J Pathol (1990) 1.35
Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene. Proc Natl Acad Sci U S A (1988) 1.35
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res (2008) 1.35
Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br J Cancer (1991) 1.31
The multidrug resistance phenotype. Br J Cancer (1988) 1.31
Tamoxifen blocks chloride channels. A possible mechanism for cataract formation. J Clin Invest (1994) 1.26
Overexpression of P-glycoprotein and glutathione S-transferase-pi in resistant non-small cell lung carcinomas of smokers. Br J Cancer (1991) 1.25
Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci U S A (1988) 1.24
Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data. BMC Genomics (2006) 1.24
The structure of the human glutathione S-transferase pi gene. Biochem J (1988) 1.23
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med (2011) 1.22
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. Biochem J (1990) 1.16
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer. Br J Cancer (1996) 1.16
Glutathione S-transferase pi in an arsenic-resistant Chinese hamster ovary cell line. Biochem J (1992) 1.06
Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem Pharmacol (2007) 1.02
Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. Proc Natl Acad Sci U S A (1987) 1.02
Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line. Breast Cancer Res (2001) 1.01
Establishment of two new cell lines derived from human breast carcinomas with HER-2/neu amplification. Br J Cancer (1991) 1.01
Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones. Br J Cancer (1996) 1.00
Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites. Br J Cancer (1993) 0.98
Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines. Br J Cancer (1995) 0.97
Identification of CD44 as a surface biomarker for drug resistance by surface proteome signature technology. Mol Cancer Res (2011) 0.94
Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines. Br J Cancer (1989) 0.93
Glutathione and related enzyme activity in human lung cancer cell lines. Br J Cancer (1988) 0.90
Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells. Methods Mol Biol (2010) 0.90
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation. Br J Cancer (1995) 0.90
Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction. Am J Pathol (1996) 0.90
A marine anthraquinone SZ-685C overrides adriamycin-resistance in breast cancer cells through suppressing Akt signaling. Mar Drugs (2012) 0.90
Atrazine Resistance in a Velvetleaf (Abutilon theophrasti) Biotype Due to Enhanced Glutathione S-Transferase Activity. Plant Physiol (1991) 0.89
The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin. Biochem J (1993) 0.89
Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia. Br J Cancer (1992) 0.88
Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. Nucleic Acids Res (1990) 0.88
A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. BMC Cancer (2011) 0.87
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines. Br J Cancer (1992) 0.87
Recombination phenotypes of the NCI-60 collection of human cancer cells. BMC Mol Biol (2011) 0.87
Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression. Br J Cancer (1998) 0.87
The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models. Br J Cancer (2003) 0.86
Human hepatoma cells rich in P-glycoprotein are sensitive to aclarubicin and resistant to three other anthracyclines. Br J Cancer (1996) 0.85
Increased expression and DNA-binding activity of transcription factor Sp1 in doxorubicin-resistant HL-60 leukemia cells. Mol Cell Biol (1990) 0.85
Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase pi gene expression in primary and relapsed state adult and childhood leukaemias. Br J Cancer (1992) 0.85
Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein. PLoS One (2014) 0.84
Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene. Biochem J (1997) 0.84
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells. Br J Cancer (1993) 0.84
A redox economical synthesis of bioactive 6,12-guaianolides. Org Lett (2013) 0.83
Observations on the transcriptional activity of the glutathione S-transferase pi gene in human haematological malignancies and in the peripheral leucocytes of cancer patients under chemotherapy. Br J Cancer (1989) 0.83
Effects of copper exposure on expression of glutathione-related genes in Acidithiobacillus ferrooxidans. Curr Microbiol (2011) 0.83
Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. Biochem J (1992) 0.82
Expression of MDR1/P glycoprotein in human sarcomas. Br J Cancer (1993) 0.82
Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin. Nucl Med Biol (2005) 0.81
Comparison of (99m)Tc-sestamibi and doxorubicin to monitor inhibition of P-glycoprotein function. Br J Cancer (2001) 0.81
Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. J Biol Chem (2014) 0.80
Mechanisms of acquired resistance to 2-(4-aminophenyl)benzothiazole (CJM 126, NSC 34445). Br J Cancer (2000) 0.80
Glutathione-doxorubicin conjugate expresses potent cytotoxicity by suppression of glutathione S-transferase activity: comparison between doxorubicin-sensitive and -resistant rat hepatoma cells. Br J Cancer (1997) 0.80
Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors. Br J Cancer (1997) 0.80
The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus. Viruses (2011) 0.79
Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. Br J Cancer (1993) 0.79
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorg Med Chem (2015) 0.78
Endogenous antioxidant enzymes and glutathione S-transferase in protection of mesothelioma cells against hydrogen peroxide and epirubicin toxicity. Br J Cancer (1998) 0.78
Cationic drug analysis using matrix-assisted laser desorption/ionization mass spectrometry: application to influx kinetics, multidrug resistance, and intracellular chemical change. Proc Natl Acad Sci U S A (1993) 0.78
Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay. Pharmaceutics (2016) 0.78
Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells. Br J Cancer (1991) 0.78
An Introspective Update on the Influence of miRNAs in Breast Carcinoma and Neuroblastoma Chemoresistance. Genet Res Int (2014) 0.78
Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics. Adv Sci (Weinh) (2016) 0.77
Expression of glutathione S-transferases in normal and malignant pancreas: an immunohistochemical study. Gut (1994) 0.77
Glutathione analogue sorbents selectively bind glutathione S-transferase isoenzymes. Biochem J (1993) 0.77
Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest. Am J Cancer Res (2015) 0.77
Multidrug resistance-associated antigens on drug-sensitive and -resistant human tumour cell lines. Br J Cancer (1991) 0.77
Do glutathione and related enzymes play a role in drug resistance in small cell lung cancer cell lines? Br J Cancer (1993) 0.77
Comparative evaluation by semiquantitative reverse transcriptase polymerase chain reaction of MDR1, MRP and GSTp gene expression in breast carcinomas. Br J Cancer (1998) 0.77
Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Biochem J (1999) 0.77
Multidrug resistance circumvention by a new triazinoaminopiperidine derivative S9788 in vitro: definition of the optimal schedule and comparison with verapamil. Br J Cancer (1994) 0.77
Glutathione Transferase (GST)-Activated Prodrugs. Pharmaceutics (2013) 0.77
Effects of exposure to a mixture of cadmium and chromium on detoxification enzyme (GST, P450-MO) activities in the frog Rana ridibunda. Ecotoxicology (2005) 0.77
In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens. Evid Based Complement Alternat Med (2015) 0.76
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF. Br J Cancer (1994) 0.76
Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy. PLoS One (2015) 0.76
BMS181321 accumulation in rodent and human cells: the role of P-glycoprotein. Br J Cancer Suppl (1996) 0.75
Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol. Biochem J (1992) 0.75
Epitope mapping of a monoclonal antibody to human glutathione transferase P1-1 the binding of which is inhibited by glutathione. Biochem J (1997) 0.75
An In Vitro Demonstration of Overcoming Drug Resistance in SKOV3 TR and MCF7 ADR with Targeted Delivery of Polymer Pro-Drug Conjugates. J Drug Target (2016) 0.75
Anticancer chemosensitivity changes between the original and recurrent tumors after successful chemotherapy selected according to the sensitivity assay. Ann Surg (1995) 0.75
Resistance to the antimitotic drug estramustine is distinct from the multidrug resistant phenotype. Br J Cancer (1991) 0.75
Adaptive response to glutathione S-transferase inhibitors. Br J Cancer Suppl (1996) 0.75
Glutathione S-transferase in bone marrow metastases of disseminated neuroblastoma. J Clin Pathol (1994) 0.75
Expression of anionic glutathione S transferase (GST pi) gene in carcinomas of the uterine cervix and in normal cervices. Br J Cancer (1991) 0.75
Overexpression of glutathione S-transferase pi messenger RNA and its relationship to gene amplification in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol (1997) 0.75
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A (1994) 6.74
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol (2001) 4.89
Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med (1995) 3.43
The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma. N Engl J Med (1996) 3.30
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Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. N Engl J Med (1997) 3.03
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin Pharmacol Ther (1987) 2.92
Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer. Cancer Treat Rep (1978) 2.42
The pharmacology and clinical use of methotrexate. N Engl J Med (1983) 2.29
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides. N Engl J Med (1989) 2.17
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest (1980) 2.03
Influence of Dead Bacteria on Microscopic Counts of Pasteurized Milk. Am J Public Health Nations Health (1937) 2.02
The anthracycline antineoplastic drugs. N Engl J Med (1981) 2.02
Cortico-striatal contributions to feedback-based learning: converging data from neuroimaging and neuropsychology. Brain (2004) 2.00
Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors. Cancer Res (1989) 1.86
Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proc Natl Acad Sci U S A (1988) 1.86
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochem Pharmacol (1985) 1.86
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res (1996) 1.82
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc Natl Acad Sci U S A (1998) 1.74
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun (2000) 1.73
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res (1994) 1.73
Posttranscriptional regulation of the c-myb proto-oncogene in estrogen receptor-positive breast cancer cells. Clin Cancer Res (1995) 1.72
Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proc Natl Acad Sci U S A (1986) 1.71
Basal ganglia and dopamine contributions to probabilistic category learning. Neurosci Biobehav Rev (2007) 1.70
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Prostate specific antigen decline following the discontinuation of flutamide in patients with stage D2 prostate cancer. Am J Med (1995) 1.60
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res (1990) 1.57
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J Biol Chem (2000) 1.57
Hippocampal mediation of stimulus representation: a computational theory. Hippocampus (1993) 1.55
Pharmacokinetics of adriamycin and tissue penetration in murine ovarian cancer. Cancer Res (1979) 1.55
Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders. J Clin Pharmacol (1988) 1.51
Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res (1997) 1.50
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene (2000) 1.50
Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells. Cancer Res (1987) 1.49
Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols. Cancer Res (1983) 1.47
Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine. J Clin Invest (1981) 1.46
Suramin: an anticancer drug with a unique mechanism of action. J Clin Oncol (1989) 1.45
Suramin-induced skin reactions. Arch Dermatol (1992) 1.45
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Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes. N Engl J Med (1983) 1.44
Hormone-dependent regulation of BRCA1 in human breast cancer cells. Cancer Res (1995) 1.43
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Role of the basal ganglia in category learning: how do patients with Parkinson's disease learn? Behav Neurosci (2004) 1.38
An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue. Am J Pathol (1990) 1.35
The clinical pharmacology of antineoplastic agents (first of two parts). N Engl J Med (1975) 1.35
Phase I study of phenylacetate administered twice daily to patients with cancer. Cancer (1995) 1.33
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Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res (1988) 1.32
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun (1997) 1.31
Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res (1999) 1.30
Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins. Mol Pharmacol (1989) 1.29
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. Clin Pharmacol Ther (1989) 1.27
Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer. Clin Cancer Res (1995) 1.26
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem (1994) 1.23
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Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes. Clin Pharmacol Ther (1980) 1.21
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
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Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res (1988) 1.20
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High-dose cisplatin in hypertonic saline in refractory ovarian cancer. J Clin Oncol (1985) 1.18
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Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Commun (1991) 1.10
Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene (2010) 1.09
Clinical pharmacokinetics of suramin in patients with HTLV-III/LAV infection. J Clin Pharmacol (1986) 1.09
Improving the therapeutic index of anthracycline chemotherapy: focus on liposomal doxorubicin (Myocet). Breast (2009) 1.09
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate. J Clin Invest (1993) 1.08
A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo. Mol Endocrinol (1988) 1.08
Phase I and pharmacological studies of adriamycin administered intraperitoneally to patients with ovarian cancer. Cancer Res (1982) 1.08
Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells. Cancer Res (1989) 1.06
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