Published in Biochimie on February 19, 1986
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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J (2000) 3.70
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem (2001) 3.09
SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem (2000) 2.61
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A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. Mol Cell Biol (1987) 2.36
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Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking. J Biol Chem (1981) 1.90
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem (1996) 1.86
Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology (1997) 1.73
Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci U S A (1981) 1.72
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol (1999) 1.68
Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res (1981) 1.68
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Internalized insulin receptors are recycled to the cell surface in rat hepatocytes. Proc Natl Acad Sci U S A (1982) 1.63
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice. J Clin Invest (1993) 1.62
Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin. Nature (1978) 1.55
Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Nature (1985) 1.50
Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J Biol Chem (1994) 1.49
Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. Proc Natl Acad Sci U S A (1983) 1.49
The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. J Biol Chem (1993) 1.48
Regulation of interleukin 2 synthesis by cAMP in human T cells. J Immunol (1987) 1.47
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes. J Biol Chem (1996) 1.46
Regulation of vascular endothelial growth factor expression by advanced glycation end products. J Biol Chem (2001) 1.45
The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells. Diabetologia (1974) 1.42
Modulation of insulin action. Diabetologia (2004) 1.41
Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. Biochem J (1993) 1.41
Insulin and glucagon stimulation of amino acid transport in isolated rat hepatocytes. Synthesis of a high affinity component of transport. J Biol Chem (1979) 1.38
Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J Biol Chem (1998) 1.38
Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo. Diabetologia (2005) 1.37
Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation. J Biol Chem (1990) 1.36
Phosphorylation of the hepatic insulin receptor: stimulating effect of insulin on intact cells and in a cell-free system. FEBS Lett (1982) 1.35
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Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation. Mol Cell Biol (2000) 1.32
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem (1996) 1.31
cAMP stimulates protein kinase B in a Wortmannin-insensitive manner. FEBS Lett (1997) 1.31
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles. Proc Natl Acad Sci U S A (1982) 1.30
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem (2000) 1.30
SOCS proteins causing trouble in insulin action. Acta Physiol (Oxf) (2008) 1.30
Surface redistribution of 125I-insulin in cultured human lymphocytes. J Cell Biol (1981) 1.27
Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes. J Cell Biol (1982) 1.27
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem J (1994) 1.26
Insulin and okadaic acid induce Rab4 redistribution in adipocytes. J Biol Chem (1993) 1.20
Role of microtubules in the phasic pattern of insulin release. Ann N Y Acad Sci (1975) 1.19
Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes. Proc Natl Acad Sci U S A (1985) 1.19
Insulin receptors: binding kinetics and structure-function relationship of insulin. Physiol Rev (1984) 1.18
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J Biol Chem (1998) 1.18
p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J Biol Chem (1998) 1.18
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Insulin and glucagon stimulation of (Na+-K+)-ATPase transport activity in isolated rat hepatocytes. J Biol Chem (1981) 1.16
Regulation of amino acid transport in the liver. Emergence of a high affinity transport system in isolated hepatocytes from fasting rats. J Biol Chem (1979) 1.16
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene (2000) 1.15
Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol Endocrinol (2003) 1.15
Time course of insulin-receptor binding and insulin-induced lipogenesis in isolated rat fat cells. J Biol Chem (1975) 1.15
Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase. Biochem J (1985) 1.15
Translational discrimination of mRNAs coding for human insulin-like growth factor II. J Biol Chem (1990) 1.14
Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. Eur J Biochem (1996) 1.13
Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration. J Biol Chem (1981) 1.12
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. Am J Physiol Endocrinol Metab (2009) 1.11
Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1. J Biol Chem (1992) 1.11
Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling. J Biol Chem (2001) 1.11
Activation of utrophin promoter by heregulin via the ets-related transcription factor complex GA-binding protein alpha/beta. Mol Biol Cell (1999) 1.11
Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor. Eur J Biochem (1994) 1.10
The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J Biol Chem (2001) 1.09
Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. J Biol Chem (1976) 1.09
Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells. Diabetes (1991) 1.08
Dynamics of insulin release and microtubular-microfilamentous system. VII. Do microfilaments provide the motive force for the translocation and extrusion of beta granules? Diabetes (1975) 1.07
Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase. J Biol Chem (2001) 1.06
IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis. J Immunol (1988) 1.06
Two different protein kinase activities are associated with the insulin receptor. Biochem J (1983) 1.04
Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae. EMBO J (1989) 1.04
Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4. Endocrinology (1991) 1.04
Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J Biol Chem (1995) 1.03
Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes. Nature (1980) 1.03
Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes: a quantitative morphological and biochemical study. J Cell Biol (1980) 1.02
Receptors for insulin-like growth factors I and II in rat gastrointestinal epithelium. Am J Physiol (1988) 1.02
Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. Endocrinology (1998) 1.01
Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. J Neurochem (1991) 1.01
Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins. J Immunol (1988) 1.01
Cross-linking of insulin receptors to MHC antigens in human B lymphocytes: evidence for selective molecular interactions. J Immunol (1986) 1.01
Insulin receptors in isolated rat hepatocytes. Reassessment of binding properties and observations of the inactivation of insulin at 37 degrees C. J Biol Chem (1978) 1.01
Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. Proc Natl Acad Sci U S A (1979) 1.01
Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J Biol Chem (1989) 1.01
Two types of receptor for insulin-like growth factors in mammalian brain. EMBO J (1985) 0.99