Published in J Cell Biol on November 01, 1980
Infectious entry pathway of influenza virus in a canine kidney cell line. J Cell Biol (1981) 6.46
Binding and uptake of diphtheria toxin by toxin-resistant Chinese hamster ovary and mouse cells. Mol Cell Biol (1983) 1.29
Intracellular potassium depletion in IM-9 lymphocytes suppresses the slowly dissociating component of human growth hormone binding and the down-regulation of its receptors but does not affect insulin receptors. Proc Natl Acad Sci U S A (1986) 1.15
Surface binding and internalization of platelet-derived growth factor in human fibroblasts. Proc Natl Acad Sci U S A (1983) 1.07
Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties. J Cell Biol (1983) 0.93
Effect of colchicine on internalization of prolactin in female rat liver: an in vivo radioautographic study. J Cell Biol (1983) 0.88
Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes. Biochem J (1985) 0.78
The human growth hormone receptor of cultured human lymphocytes. Structural characteristics and glycosylation properties. Biochem J (1986) 0.75
Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells. J Clin Invest (1989) 0.75
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts. J Cell Biol (1976) 10.88
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sci U S A (1978) 6.59
Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci U S A (1978) 5.91
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431. J Cell Biol (1979) 5.62
Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proc Natl Acad Sci U S A (1976) 4.17
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47
Fate of plasma membrane during endocytosis. II. Evidence for recycling (shuttle) of plasma membrane constituents. J Cell Biol (1979) 2.30
Resolution in electron microscope autoradiography. III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters. J Cell Biol (1977) 2.00
Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes. Science (1978) 1.66
Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography. J Clin Invest (1979) 1.63
Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay. J Biol Chem (1974) 1.63
Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes. J Biol Chem (1976) 1.62
Degradation of receptor-bound human choriogonadotropin by murine Leydig tumor cells. J Biol Chem (1978) 1.48
Proliferation and differentiation of lymphoid cells: studies with human lymphoid cell lines and immunoglobulin synthesis. Ann N Y Acad Sci (1971) 1.43
Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation. J Biol Chem (1979) 1.42
Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study. J Cell Biol (1979) 1.38
Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study. Exp Cell Res (1979) 1.32
Entry of insulin into human cultured lymphocytes: electron microscope autoradiographic analysis. Science (1978) 1.25
Mode of uptake and degradation of 125I-labelled insulin by isolated hepatocytes and H4 hepatoma cells. Can J Biochem (1979) 1.19
Accumulation of a slowly dissociable peptide hormone binding component by isolated target cells. Proc Natl Acad Sci U S A (1978) 0.96
Less-understood aspects of the morphology of insulin secretion and binding. Recent Prog Horm Res (1978) 0.94
Insulin-induced receptor loss in the cultured human lymphocyte: quantitative morphological perturbations in the cell and plasma membrane. J Cell Sci (1979) 0.86
Autoradiographic studies of 3H-dexamethasone uptake by immunocytochemically characterized cells of the rat pituitary. Cell Tissue Res (1977) 0.85
Estradiol-induced redistribution of lysosomal proteins in rat preputial gland. Evidence from immunologic probes. J Cell Biol (1977) 0.78
125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures. Experientia (1979) 0.78
COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell (1994) 10.01
Molecular dissection of the secretory pathway. Nature (1992) 7.38
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem (1978) 7.15
Coat proteins and vesicle budding. Science (1996) 7.00
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell (1991) 6.30
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell (1987) 5.80
Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A (2000) 5.65
Involvement of GTP-binding "G" proteins in transport through the Golgi stack. Cell (1987) 5.28
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell (1991) 4.80
COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Cell (1998) 4.73
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J (2001) 4.70
Purification of a novel class of coated vesicles mediating biosynthetic protein transport through the Golgi stack. Cell (1989) 4.65
Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell (1988) 4.37
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Nature (1991) 4.09
A new type of coated vesicular carrier that appears not to contain clathrin: its possible role in protein transport within the Golgi stack. Cell (1986) 4.04
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci U S A (1986) 3.42
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway. Proc Natl Acad Sci U S A (1987) 3.33
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem (2001) 3.09
Binding of coatomer to Golgi membranes requires ADP-ribosylation factor. J Biol Chem (1993) 3.01
Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol (1981) 2.94
In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J Cell Biol (1983) 2.91
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell (1999) 2.89
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast. Cell (1995) 2.87
New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes (1982) 2.87
Functional subdivision of islets of Langerhans and possible role of D cells. Lancet (1975) 2.83
Stepwise assembly of functionally active transport vesicles. Cell (1993) 2.80
The osmotic integrity of the yeast cell requires a functional PKC1 gene product. Mol Cell Biol (1992) 2.78
Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell (1991) 2.78
Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell (1990) 2.77
Forty-eight-hour fast: the diagnostic test for insulinoma. J Clin Endocrinol Metab (2000) 2.75
Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. J Cell Biol (1994) 2.75
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell (2000) 2.69
Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A (1988) 2.69
Direct identification of prohormone conversion site in insulin-secreting cells. Cell (1985) 2.64
Pancreatic beta-cell web: its possible role in insulin secretion. Science (1972) 2.63
SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem (2000) 2.61
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell (1985) 2.58
Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med (1967) 2.55
The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet (1975) 2.54
Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest (1984) 2.52
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. J Cell Biol (1993) 2.51
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47
Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun (1992) 2.47
Heterogeneous distribution of filipin--cholesterol complexes across the cisternae of the Golgi apparatus. Proc Natl Acad Sci U S A (1981) 2.45
Dynamics of the COPII coat with GTP and stable analogues. Nat Cell Biol (2001) 2.44
Macro- and micro-domains in the endocrine pancreas. Diabetes (1982) 2.43
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S A (1997) 2.42
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. Mol Cell Biol (1987) 2.36
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol (1990) 2.36
A view of acidic intracellular compartments. J Cell Biol (1988) 2.35
Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell (1987) 2.33
Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A (1999) 2.33
The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport. J Biol Chem (1992) 2.31
Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development (1991) 2.28
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J (1998) 2.25
Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun (1991) 2.25
Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J Histochem Cytochem (1989) 2.23
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem (1986) 2.22
A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J Cell Biol (1996) 2.20
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. Exp Cell Res (1978) 2.15
Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc Natl Acad Sci U S A (1998) 2.15
A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers. J Biol Chem (1973) 2.13
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest (1976) 2.12
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J (2000) 2.08
Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol (1986) 2.06
Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med (1995) 2.05
Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol (1990) 2.00
A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell (1984) 1.99
Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J Cell Sci (1995) 1.98
Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes (1982) 1.94
Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction. J Clin Invest (1975) 1.92
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites. EMBO J (1988) 1.92
The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr Rev (1982) 1.92
Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking. J Biol Chem (1981) 1.90
Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts. J Cell Biol (1982) 1.88
Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Engl J Med (1979) 1.88
Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae. J Cell Biol (2000) 1.87
Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol. J Cell Sci (1983) 1.87
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem (1996) 1.86
Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science (1990) 1.85
Glucose intolerance in cystic fibrosis. N Engl J Med (1969) 1.85