Published in J Clin Invest on April 01, 1985
Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK 11-4 screened from Chungkook-Jang. Appl Environ Microbiol (1996) 1.22
The effect of selenium enrichment on baker's yeast proteome. J Proteomics (2011) 0.88
Connective tissue: Vascular and hematological (blood) support. J Chiropr Med (2003) 0.75
Diffusion-in-gel methods for immunological analysis. Prog Allergy (1958) 27.50
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. J Biol Chem (1970) 19.51
Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders. Gastroenterology (1974) 3.33
Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes. Biochemistry (1969) 2.61
A proenzyme form of human urokinase. J Biol Chem (1982) 1.98
Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody. Biochemistry (1982) 1.85
Kinetics of activation of human plasminogen by different activator species at pH 7.4 and 37 degrees C. J Biol Chem (1980) 1.63
Differences in the binding to fibrin of native plasminogen and plasminogen modified by proteolytic degradation. Influence of omega-aminocarboxylic acids. Biochim Biophys Acta (1975) 1.53
The detection of fibrinogen-fibrin degradation products by means of a new antibody-coated latex particle. J Clin Pathol (1972) 1.50
Isolation and characterization of urokinase from human plasma. J Biol Chem (1982) 1.47
Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions. Thromb Res (1984) 1.46
Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma. Blood (1984) 1.44
Immobilized metal ion affinity adsorption and immobilized metal ion affinity chromatography of biomaterials. Serum protein affinities for gel-immobilized iron and nickel ions. Biochemistry (1983) 1.36
Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species. J Clin Invest (1984) 1.22
Physiological activation of the human fibrinolytic system. Isolation and characterization of human plasminogen variants, Chicago I and Chicago II. J Biol Chem (1979) 1.17
Physico-chemical and proenzyme properties of NH2-terminal glutamic acid and NH2-terminal lysine human plasminogen. Influence of 6-aminohexanoic acid. Biochim Biophys Acta (1974) 1.14
Plasminogen and plasmin. Methods Enzymol (1976) 1.11
Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase. J Clin Invest (1982) 1.04
Methods for determination of prekallikrein in plasma, glandular kallikrein and urokinase. Haemostasis (1978) 0.88
Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase. J Biol Chem (1984) 0.85
Urokinase-like plasminogen activators of unusually high molecular weight secreted by a cell line derived from a human lung cancer case. J Biol Chem (1982) 0.85
Differential binding of plasminogen to crosslinked and noncrosslinked fibrins: its significance in hemostatic defect in factor XIII deficiency. Blood (1984) 0.83
Oral administration of urokinase. Thromb Res (1981) 0.82
Identification of the plasminogen activator(s) produced by the transformed liver cell line, SK-HEP-1. Thromb Res (1983) 0.81
A functionally active heavy chain derived from human high molecular weight urokinase. J Biol Chem (1983) 0.80
The immunoassay of human urokinase. Thromb Diath Haemorrh (1969) 0.78
Production of the modified form of human plasminogen in the plasma activated by urokinase. Jpn J Physiol (1983) 0.77
A simple and rapid purification method of urokinase using a [Nalpha-(epsilon-aminocaproyl)-DL-homoarginine hexylester]-sepharose column. Nihon Ketsueki Gakkai Zasshi (1978) 0.77
Measurement of plasminogen and two antiplasmins by L-lysine sepharose affinity chromatography. Hiroshima J Med Sci (1974) 0.77
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06
The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J Physiol (1966) 5.14
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11
Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation (2001) 4.01
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59
Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology (2010) 3.35
Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase. Science (1984) 3.06
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature (1983) 3.01
Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Proc Natl Acad Sci U S A (1983) 2.95
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.93
Stabilization of platinum oxygen-reduction electrocatalysts using gold clusters. Science (2007) 2.75
Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci U S A (1981) 2.74
Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin. Br J Dermatol (2003) 2.69
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. J Biol Chem (1984) 2.58
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55
Isolation and oncogenic potential of a novel human src-like gene. Mol Cell Biol (1986) 2.31
Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin. Nature (1983) 2.30
Molecular cloning of Moloney murine sarcoma virus: arrangement of virus-related sequences within the normal mouse genome. Proc Natl Acad Sci U S A (1979) 2.27
Parallel fibre stimulation and the responses induced thereby in the Purkinje cells of the cerebellum. Exp Brain Res (1966) 2.23
The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol Cell Biol (1988) 2.22
A large family of class III plant peroxidases. Plant Cell Physiol (2001) 2.21
Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study. Neurology (2011) 2.17
Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol (1995) 2.15
c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol (2001) 2.10
Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm? Neurosurgery (2001) 2.08
Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39. Mol Cell Biol (1995) 2.03
The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin. J Biol Chem (1967) 2.01
Reconstruction of the lacrimal excretory system. Plast Reconstr Surg (1992) 2.01
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci U S A (1991) 2.00
Rat sequences of the Kirsten and Harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor RNA. J Virol (1976) 1.99
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A (1990) 1.98
The transforming gene of Moloney murine sarcoma virus. Nature (1979) 1.98
Intracellularly recorded responses of the cerebellar Purkinje cells. Exp Brain Res (1966) 1.81
Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation. Cell (1984) 1.80
Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides (2006) 1.80
Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer. Clin Cancer Res (2001) 1.79
Interaction experiments on the responses evoked in Purkinje cells by climbing fibres. J Physiol (1966) 1.78
The inhibitory interneurones within the cerebellar cortex. Exp Brain Res (1966) 1.76
Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res (1999) 1.76
Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology (2001) 1.72
The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein. EMBO J (1985) 1.72
Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. Proc Natl Acad Sci U S A (1982) 1.72
Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J Cell Biol (1997) 1.69
fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature (1986) 1.64
Kinetics of activation of human plasminogen by different activator species at pH 7.4 and 37 degrees C. J Biol Chem (1980) 1.63
Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Cell (1984) 1.61
Acquisition of transforming properties by FYN, a normal SRC-related human gene. Proc Natl Acad Sci U S A (1988) 1.60
Segregation of genetic information for a B-tropic leukemia virus with the structural locus for BALB:virus-1. Proc Natl Acad Sci U S A (1977) 1.57
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. Proc Natl Acad Sci U S A (1986) 1.56
X-ray analysis of glucagon and its relationship to receptor binding. Nature (1975) 1.56
Primary structure of the human fgr proto-oncogene product p55c-fgr. Mol Cell Biol (1988) 1.48
Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. J Virol (1989) 1.47
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (1988) 1.47
The mossy fibre-granule cell relay of the cerebellum and its inhibitory control by Golgi cells. Exp Brain Res (1966) 1.46
Vitamin C administration attenuates overload-induced skeletal muscle hypertrophy in rats. Acta Physiol (Oxf) (2013) 1.46
Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study. Acta Psychiatr Scand (2010) 1.45
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells. J Biol Chem (1995) 1.44
Non-familial olivopontocerebellar atrophy combined with late onset Alzheimer's disease: a clinico-pathological case report. J Neurol Sci (1998) 1.44
In vivo identification of the transforming gene product of simian sarcoma virus. Science (1982) 1.44
Identification of recurrent chromosomal rearrangements and the unique relationship between low-level amplification and translocation in glioblastoma. Genes Chromosomes Cancer (2001) 1.43
Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem (1994) 1.42
A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors. Nature (1987) 1.42
The cadherin-like protein is essential to specificity determination and cytotoxic action of the Bacillus thuringiensis insecticidal CryIAa toxin. FEBS Lett (1999) 1.42
Effect of Calcium Chloride on the Preparation of Extracts of H. pertussis. Science (1948) 1.42
Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor. Science (1985) 1.39
Long-term regulation of interferon production by lymphocytes from children inoculated with live measles virus vaccine. J Infect Dis (1988) 1.39
Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo. Pharm Res (2001) 1.38
Mosaic pattern of dystrophins in Duchenne muscular dystrophy. Pediatr Neurol (1990) 1.38
Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology (1999) 1.37
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain. Genes Dev (1991) 1.36
Highly bright X-ray generator using heat of fusion with a specially designed rotating anticathode. J Synchrotron Radiat (2008) 1.36
Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies. Int J Cancer (1995) 1.36
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene (1995) 1.35
Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem (1997) 1.32
Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumor-bearing mice. Int J Pharm (1999) 1.32
Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. Proc Natl Acad Sci U S A (1989) 1.32
Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res (1987) 1.30
c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3. EMBO J (1993) 1.29
Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc Natl Acad Sci U S A (1989) 1.29
A simplified cataract grading system. Ophthalmic Epidemiol (2002) 1.28
Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study. Eye (Lond) (2003) 1.28
A cephalometric and electromyographic study of upper airway structures in the upright and supine positions. Am J Orthod Dentofacial Orthop (1994) 1.27
Protein D, a putative immunoglobulin D-binding protein produced by Haemophilus influenzae, is glycerophosphodiester phosphodiesterase. J Bacteriol (1993) 1.27
[Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent]. Yakugaku Zasshi (1991) 1.26
Causative factors of retinal detachment in macular holes. Retina (1991) 1.25
An autopsy case of a syndrome with muscular atrophy, decreased subcutaneous fat, skin eruption and hyper gamma-globulinemia: peculiar vascular changes and muscle fiber degeneration. Acta Neuropathol (1987) 1.25
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. Circulation (2000) 1.25
Low-temperature-dependent ribonuclease in chromatin of winter wheat seedlings. Biochem Biophys Res Commun (1976) 1.23
Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A (1985) 1.22
Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling. J Biol Chem (1993) 1.22
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets. Mol Cell Biol (1990) 1.21
Essential role of myosin light chain kinase in the mechanism for MgATP-dependent priming of exocytosis in adrenal chromaffin cells. J Neurosci (1994) 1.20
Use of enzyme-linked antibodies to measure serum anti-DNA antibody in systemic lupus erythematosus. Clin Chem (1974) 1.20
'Error' potentials in limbic cortex (anterior cingulate area 24) of monkeys during motor learning. Neurosci Lett (1986) 1.19
Characteristic features of augmenting and recruiting responses in the cerebral cortex. Exp Neurol (1970) 1.19
Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomas. Cancer Res (1998) 1.18
Presence of HTLV-I proviral DNA in central nervous system of patients with HTLV-I-associated myelopathy. Ann Neurol (1992) 1.18
Physiological activation of the human fibrinolytic system. Isolation and characterization of human plasminogen variants, Chicago I and Chicago II. J Biol Chem (1979) 1.17